Josh Michaud Profile picture
Aug 2, 2020 23 tweets 7 min read Read on X
Hard to deny that travel bans are now a key tool in the pandemic prevention toolbox. Fascinating to see how #COVID19 upended prior global health conventional wisdom about travel bans for epidemics and pandemics
Policies have evolved alongside the pandemic. In Jan @WHO recommended against travel restrictions when it declared coronavirus a public health emergency of international concern who.int/news-room/deta…
In Feb/Mar, WHO advise against the "application of travel or trade restrictions to countries experiencing COVID-19 outbreaks” and recommended “health measures be implemented in ways that minimize unnecessary interference w international traffic and trade”
who.int/news-room/arti…
WHO’s recommendations were in line with the previous consensus among public health experts that bans do more harm than good, and with prevailing interpretations of the International Health Regulations
For example, an editorial in late Feb stated that travel restrictions against China during COVID-19 violated international law, and “evidence belies the claim that illegal travel restrictions make countries safer” thelancet.com/journals/lance…
Even so WHO officials still recommended caution at that time: “restrictions must be based on a careful risk assessment, be proportionate to the public health risk, be short in duration, and be reconsidered regularly” thelancet.com/journals/lance…
However, travel bans were widespread already by then. 100% of countries had travel restrictions in place and 72% of countries had “placed a complete stop on international tourism” by April unwto.org/news/covid-19-…
Travel bans have been part of the success in countries suppressing the virus. Here is New Zealand’s Jacinda Ardern announcing "far-reaching and unprecedented" restrictions and touting the “toughest border restrictions of any country in the world” in March. abc.net.au/news/2020-03-1…
Studies show travel restrictions can reduce cross-border spread. Research from Australia: “Travel restrictions were highly effective for containing the COVID-19 epidemic in Australia during the epidemic peak in China and averted a much larger epidemic” academic.oup.com/jtm/article/do…
Another study: “travel restrictions…may decrease the rate of case exportations if enacted during the early stages of the epidemic… This obstruction of importation events will be critical to preparing an effective public health response” pnas.org/content/117/13…
But not all travel bans are created equal. Bans on travel from China early in the pandemic, were mostly too little too late and, at most, only delayed exportation of the virus into other countries. science.sciencemag.org/content/368/64…
Supporting this notion, an analysis of countries with and without early bans on travel from China found no association with countries’ subsequent outbreak size and timing. thinkglobalhealth.org/article/tracki…
Travel bans implemented haphazardly and/or incompletely offer little prevention value. The March ban on Europeans entering the US for example, did not help and might have made things worse washingtonpost.com/world/national…
If a country already has widespread community transmission, the relative importance and effectiveness is reduced. The risk from imported cases can become dwarfed by the risk from domestic transmission.
Because the pandemic is a dynamic situation, countries can be “net importers” or “net exporters” of disease at different times as they successfully or unsuccessfully suppress the virus. So, the relative effectiveness of travel bans can shift.
Since the April peak the has been a slow easing of travel restrictions. In July 40% of countries worldwide eased restrictions. However, over half of countries have kept their borders completely closed to tourism unwto.org/news/tourism-r…
Particularly in countries with low levels of transmission, travel bans remain in place to help prevent further surges or “second waves” of disease driven by imports.
According to @IATA there are only a few countries that *do not* currently place bans on international passenger arrivals, such as Brazil, Egypt, Mexico, Serbia, Tanzania, and Ukraine
iatatravelcentre.com/international-…
So there is a complex interplay between a shifting epidemiological picture across countries, and differences in effectiveness of policies as implemented by countries. Raises broader questions about international cooperation and tourism in a world where many borders are closed
For example, with the epidemic in the US out of control at the moment, Americans are currently blocked from entering most countries around the world at the moment. cnn.com/travel/article…
For its part, WHO released new guidelines a few days ago, providing recommendations on how countries could ease travel restrictions safely: “gradual lifting of travel measures…should be based on a thorough risk assessment… who.int/news-room/arti…
“…taking into account country context the local epidemiology and transmission patterns, the national health and social measures to control the outbreak, and the capacities of health systems in both departure and destination countries”
Seems like a fruitful area for more study as travel circumstances are changing. Under what conditions do travel bans make sense? What are the effects of imposing/relaxing bans?

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More from @joshmich

Sep 30, 2022
Starting to get a sense of the public's understanding of, and demand for, the new bivalent Covid booster:

-1/2 of adults have heard little or nothing about the new booster

-4 in 10 fully vaccinated adults not sure if CDC recommends the booster for them

kff.org/coronavirus-co…
Results from a new @KFF vaccine monitor release.

On a positive note, 8% of adults 65+ say they got the booster in (approx) 3 weeks since its release, and close to 40% more say they plan to get it as soon as possible.
The groups among fully vaccinated adults most likely to express they aren’t sure if the bivalent booster is recommended for them include: rural residents (54%), Hispanic adults (51%), and those without a college degree (49%).
Read 5 tweets
Oct 6, 2021
Wonderful: a malaria vaccine is now recommended for use in high burden areas, and could save tens of thousands of lives a year
who.int/news/item/06-1…

(For sense of the timing: initial Phase 3 trial results for this vaccine were published a decade ago!)
nejm.org/doi/10.1056/NE…
WHO and others careful to note the vaccine is best positioned as one component of a comprehensive public health approach to malaria prevention. It is burdensome (4 shots over 18 months) and perhaps 50% effective in preventing severe malaria in kids.
Unclear how quickly it can be rolled out in African countries given the resources focused on Covid-19 vaccine distribution.

“We’re really going to have to see how the pandemic unfolds next year in terms of when countries will be ready"
nytimes.com/2021/10/06/hea…
Read 6 tweets
Oct 6, 2021
In 2022, protein-based COVID-19 vaccines could be what mRNA vaccines have not been for many lower-income countries: accessible and relatively easy to manage. Slower out of the gate than other vaccines, there are now several candidates on the near horizon. 1/
They are refrigerator stable, have promising safety profiles, and efficacy that in many cases rivals mRNA vaccines. Protein vaccines are also readily scalable, with good prospects for technology transfer 2/
nature.com/articles/d4158…
Novavax, delayed for months with manufacturing and supply woes, recently filed for authorization in several countries and WHO for its protein-based vaccine. COVAX has already purchased more Novavax doses (900 M) than any other vaccine in its portfolio 3/
launchandscalefaster.org/covid-19/vacci…
Read 9 tweets
Oct 4, 2021
Over 7 billion Covid-19 vaccine doses have been produced globally to date, with >1.35 billion more doses produced each month now.

Sinovac and Sinopharm produce the greatest number of vaccines monthly, with Pfizer and AstraZeneca not far behind. 1/
By the end of this year the world is likely to produce over 12 billion vaccine doses of all vaccine types.

By June 2022 the number produced could reach double that – 24 billion doses (assuming all goes well, and it usually doesn’t) 2/
Even after reserving doses for boosters, Western countries are likely to accumulate large stockpiles of vaccines over the coming months, perhaps as many as 1.2 billion doses by the end of this year.

These “surplus” doses could be redistributed to lower income countries. 3/
Read 7 tweets
Aug 25, 2021
Keeping a wary eye on Covid trends in South America. The good: cases/deaths there have come down from devastating peaks a few months back, and there’s progress on vaccinations. The bad: Delta may have only begun to circulate, and questions about vaccine efficacy
Most countries in the region have fully vaccinated between 20 and 40% of their populations; Chile and Uruguay stand out, with >70% fully vaccinated. Countries use a mix of vaccines, mostly Chinese inactivated vaccines (Sinovac and Sinopharm), plus some Pfizer & AstraZeneca
Chinese vaccines have lower effectiveness vs symptomatic disease but protect vs hospitalizations and death.
Chile estimated the Sinovac VE vs. symptomatic Covid at 58%, and 86% vs hospitalization. For Pfizer: 88% and 97%, AZ: 68% and 100%, respectively
minsal.cl/wp-content/upl…
Read 11 tweets
Aug 23, 2021
Some initial thoughts on full FDA approval of the Pfizer vaccine and what it might mean for vaccine acceptance in the US, based on @KFF polling and policy work
A commonly referenced finding from KFF's vaccine monitor is that 3 in 10 unvaccinated people reported they'd be more likely to get the vaccine upon full FDA approval
kff.org/coronavirus-co…
Still, I don't think it means that if unvaccinated people hear the news about full FDA approval 3 in 10 of will all of a sudden decide to get the shot based on that alone.
Read 8 tweets

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