Researchers from the Systemic Synuclein Sampling Study report provides class III evidence that total cerebrospinal fluid α-synuclein does not accurately distinguish #Parkinsons from healthy controls
n.neurology.org/content/early/…
n.neurology.org/content/early/…
Lower total α-syn levels in CSF in #Parkinsons, but specificity is low.
Plus α-syn monoclonal antibody staining on skin & submandibular gland samples is specific for PD, but sensitivity is low.
Plus α-syn monoclonal antibody staining on skin & submandibular gland samples is specific for PD, but sensitivity is low.
This sentence in particular: "Relationships within subjects across different tissues & biofluids could not be demonstrated"
When systemic conditions get territorial? Or is it time to go back to the drawing board on this whole α-syn/#Parkinsons thing?
When systemic conditions get territorial? Or is it time to go back to the drawing board on this whole α-syn/#Parkinsons thing?
