NO! 🤷♂️
There's no clear consensus, but generally you need to have:
▶️Decompensated cirrhosis
▶️Acute change 2/2 sudden inflammatory state (infection, acute hepatitis, etc)
▶️End organ damage
2/10
👉The most common etiology of AoCLF is bacterial infection, and so start by looking there (and don't forget occult SBP!)
jwatch.org/na50598/2020/0…
3/10
See 👇@DebbieShawcros1's paper to read more about ammonia metabolism changes ncbi.nlm.nih.gov/pmc/articles/P…
4/10
5/10
🔸AoCLF is a worsening of decompensated cirrhosis w/ new end organ damage due to an inciting event (often bacterial infection)
and
🔸AoCLF is NOT ALF
6/10
🔸30-day mortality of ALF is around 26%, while for AoCLF, it's around 40%, almost twice as high (although this number also depends on amount of organs failing, and up to 97%❗️)
7/10
▶️Treat underlying inciting event, as best as possible
▶️Supportively manage end organ damage, as best as possible
▶️Consider liver transplant, if all else fails.
8/10
1⃣ AoCLF ≠ ALF
2⃣ AoCLF is an acute worsening of hepatic function in someone who already has evidence of cirrhosis
3⃣ Most common cause is bacterial infection (don't forget about occult SBP)
4⃣ Outcomes are worse for AoCLF than ALF
5⃣ Treat supportively
9/10