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1) Russia’s approval of an early vaccine candidate is reckless as it places domestic- and geo-politics ahead of science and medicine. According to the @WHO vaccine tracker, the Gamaleya candidate hasn't even cleared Phase II, let alone Phase III...🧵
nytimes.com/2020/08/11/wor…
2) That means the candidate vaccine is well behind Moderna, Sinovac, Oxford, and 5 others that are all in phase III. According to the clinical trials tracker, it's been tested for production of antibodies in a small number of healthy, under 60 age group...
clinicaltrials.gov/ct2/show/NCT04…
3) That's not a large-scale field trial where 1000s are vaccinated and compared to placebo for protection against the virus. Phase III is critical to show safety and efficacy especially in the over 60 age group that is the most vulnerable to SARS-C0V-2...
ncbi.nlm.nih.gov/pmc/articles/P…
4) In 20th century we worked w/Soviet Union & @WHO to wipe out Smallpox after it killed hundreds of millions. Today, in the midst of a pandemic that requires global cooperation, our leaders are pursuing narrow, nationalistic agendas. We need #ScienceDiplomacy more than ever.
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Dr. Ali Nouri
@AliNouriPhD
NEW PERSPECTIVE PIECE: masks can be leaky but even when they don't catch all the virus, it appears that they catch enough of it to only cause mild disease. Can less viral load result in less severe disease? That's been seen for others pathogens. How about for SARS-CoV-2?...🧵
2) when mask partitions were used between hamster cages, they didn't stop SARS-CoV-2 completely but the resulting disease was mild. And in human populations with wide-spread masking we're seeing more and more asymptomatic and mild infections...
3)on Diamond Princess only ~20% of infected was asymptomatic but on another ship where all passengers were issued masks the rate was ~80%. Even more evidence: Indiana pediatric unit (where patients & staff were masked) staff that contracted the virus didn't develop symptoms...
Read 4 tweets
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Dr. Ali Nouri
@AliNouriPhD
1) NYT OP-ED: Yes, the Coronavirus Is in the Air

As we cough, sneeze, talk, breathe, we release droplets (small fluid particles) and aerosols (smaller fluid particles) into the air. The transmission of SARS-CoV-2 via aerosols matters much more than officially acknowledged.🧵
2)U. Nebraska Research found aerosols containing SARS-2 in rooms of COVID19 patients. Others found patients release SARS-2 by exhaling—without coughing or even talking. And one person is thought to have infected 52 at choir practice, likely via aerosols...
nature.com/articles/s4159…
3) Current guidance holds, but should be augmented: reminder to also open windows and improve airflow indoors. And the quality of masks and their fit matters too.

This and more excellent recommendations on how to protect yourself from @linseymarr
nytimes.com/2020/07/30/opi…
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Dr. Ali Nouri
@AliNouriPhD
1) It's official: research that found infectious SARS-CoV-2 in air samples has been peer-reviewed: "significant environmental contamination in rooms where patients infected with SARS-CoV-2 are housed and cared for, regardless of the degree of symptoms" @Prof_Lowe @nature
2) Window ledges not used by patient also contaminated, likely carried by airflow. Hallway air samples turned up viral aerosols, likely carried by those exiting room. Personal air samplers all positive, despite absence of cough by most patients while sampling took place...
3) Study suggests SARS-CoV-2 environmental contamination around COVID-19 patients is extensive, and hospital procedures should account for the risk of fomite, and potentially airborne, transmission of the virus.
nature.com/articles/s4159…
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