Josh Michaud Profile picture
Aug 13, 2020 7 tweets 2 min read Read on X
A few weeks ago @ForeignAffairs asked a group of experts if they agreed or disagreed with the following statement (and level of confidence):

"The daily tally of COVID-19 cases around the world will be higher at the beginning of 2021 than it is today."

foreignaffairs.com/ask-the-expert…
Prediction is a fool's game, especially when it comes to pandemics, but even so a number of us responded. Most agreed with the statement, some with fairly high levels of confidence.
I disagreed with the statement (though with little confidence).

When we were asked to weigh in, the global average number of new cases was surpassing 200,000 daily. So I thought, how might that level compare to the tally we will see in the first weeks of 2021?
Based on nothing but speculation, my thinking was that even with a fall wave in the northern hemisphere, by the time we cross into 2021 we're more likely to see declining numbers that would total less than 200,000 cases daily.
My optimistic read is that most northern hemisphere countries are better positioned and less likely to be caught by surprise with big epidemic waves.
Another optimistic take (wishful thinking?) is that the US would have seen the worst of its epidemic by early next year, and I hope (pray) the huge number of daily cases we're seeing now doesn't continue through early 2021, even there is a fall surge here.
Anyway, who knows? Will be interesting if we take a look at global numbers in early 2021 to see where things stand and compare against our cloudy crystal balls.

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More from @joshmich

Sep 30, 2022
Starting to get a sense of the public's understanding of, and demand for, the new bivalent Covid booster:

-1/2 of adults have heard little or nothing about the new booster

-4 in 10 fully vaccinated adults not sure if CDC recommends the booster for them

kff.org/coronavirus-co…
Results from a new @KFF vaccine monitor release.

On a positive note, 8% of adults 65+ say they got the booster in (approx) 3 weeks since its release, and close to 40% more say they plan to get it as soon as possible.
The groups among fully vaccinated adults most likely to express they aren’t sure if the bivalent booster is recommended for them include: rural residents (54%), Hispanic adults (51%), and those without a college degree (49%).
Read 5 tweets
Oct 6, 2021
Wonderful: a malaria vaccine is now recommended for use in high burden areas, and could save tens of thousands of lives a year
who.int/news/item/06-1…

(For sense of the timing: initial Phase 3 trial results for this vaccine were published a decade ago!)
nejm.org/doi/10.1056/NE…
WHO and others careful to note the vaccine is best positioned as one component of a comprehensive public health approach to malaria prevention. It is burdensome (4 shots over 18 months) and perhaps 50% effective in preventing severe malaria in kids.
Unclear how quickly it can be rolled out in African countries given the resources focused on Covid-19 vaccine distribution.

“We’re really going to have to see how the pandemic unfolds next year in terms of when countries will be ready"
nytimes.com/2021/10/06/hea…
Read 6 tweets
Oct 6, 2021
In 2022, protein-based COVID-19 vaccines could be what mRNA vaccines have not been for many lower-income countries: accessible and relatively easy to manage. Slower out of the gate than other vaccines, there are now several candidates on the near horizon. 1/
They are refrigerator stable, have promising safety profiles, and efficacy that in many cases rivals mRNA vaccines. Protein vaccines are also readily scalable, with good prospects for technology transfer 2/
nature.com/articles/d4158…
Novavax, delayed for months with manufacturing and supply woes, recently filed for authorization in several countries and WHO for its protein-based vaccine. COVAX has already purchased more Novavax doses (900 M) than any other vaccine in its portfolio 3/
launchandscalefaster.org/covid-19/vacci…
Read 9 tweets
Oct 4, 2021
Over 7 billion Covid-19 vaccine doses have been produced globally to date, with >1.35 billion more doses produced each month now.

Sinovac and Sinopharm produce the greatest number of vaccines monthly, with Pfizer and AstraZeneca not far behind. 1/
By the end of this year the world is likely to produce over 12 billion vaccine doses of all vaccine types.

By June 2022 the number produced could reach double that – 24 billion doses (assuming all goes well, and it usually doesn’t) 2/
Even after reserving doses for boosters, Western countries are likely to accumulate large stockpiles of vaccines over the coming months, perhaps as many as 1.2 billion doses by the end of this year.

These “surplus” doses could be redistributed to lower income countries. 3/
Read 7 tweets
Aug 25, 2021
Keeping a wary eye on Covid trends in South America. The good: cases/deaths there have come down from devastating peaks a few months back, and there’s progress on vaccinations. The bad: Delta may have only begun to circulate, and questions about vaccine efficacy
Most countries in the region have fully vaccinated between 20 and 40% of their populations; Chile and Uruguay stand out, with >70% fully vaccinated. Countries use a mix of vaccines, mostly Chinese inactivated vaccines (Sinovac and Sinopharm), plus some Pfizer & AstraZeneca
Chinese vaccines have lower effectiveness vs symptomatic disease but protect vs hospitalizations and death.
Chile estimated the Sinovac VE vs. symptomatic Covid at 58%, and 86% vs hospitalization. For Pfizer: 88% and 97%, AZ: 68% and 100%, respectively
minsal.cl/wp-content/upl…
Read 11 tweets
Aug 23, 2021
Some initial thoughts on full FDA approval of the Pfizer vaccine and what it might mean for vaccine acceptance in the US, based on @KFF polling and policy work
A commonly referenced finding from KFF's vaccine monitor is that 3 in 10 unvaccinated people reported they'd be more likely to get the vaccine upon full FDA approval
kff.org/coronavirus-co…
Still, I don't think it means that if unvaccinated people hear the news about full FDA approval 3 in 10 of will all of a sudden decide to get the shot based on that alone.
Read 8 tweets

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