Fascinating and important paper by @VirusesImmunity and team on sex differences in immune response to COVID-19. nature.com/articles/s4158… @YaleMed 
@VirusesImmunity @YaleMed What they found… “First... levels of several important proinflammatory innate immune chemokines and cytokines such as IL-8, IL-18 (at base-line), and CCL5 (longitudinal analysis) were higher in male patients, which correlated with higher non-classical monocytes (at baseline)."
@VirusesImmunity @YaleMed "Second, [they] observed a more robust T cell response among female patients compared to male patients at baseline. In particular, activated CD8 T cells were significantly elevated only in female patients but not in male patients over healthy volunteers."
@VirusesImmunity @YaleMed What they write is… "These analyses also provide a potential basis for taking sex-dependent approaches to prognosis, prevention, care, and therapy for patient with COVID-19."
