If someone punches you in the arm, you will get a bruise, and it will eventually get better (unless you die from complications of a broken bone).
Raised CRP
Raised CK from the traumatised muscle
It will probably hurt a lot.
Then it will get better and go away.
And I suspect it will hang around a lot longer than the blood tests.
But who knows, some signs may hang around for ever.
(The example I give is a grazed knee - technically you are scarred for life, but you don't get life trauma over it: mummy just kisses it better.)
Who?
People with cancer.
People with haemophilia and other such diseases of disordered coagulation.
"People with spontaneous bruising"
and
"People without spontaneous bruising"
Who do you think would have the worse long term outcome from cancer?
A tiny basal cell carcinoma here
A small prostate neoplasm there
etc.
And many people with widespread metastases and bone marrow involvement will be in the bruising group.
NOW Francis Industries kicks into high gear, and starts diagnosing elevated B1 and B2 all over the place.
But it is not people being about to die, from self exploding muscles.
It is people recovering from being punched in the arm.
A test may be a bad warning sign in one condition, but not in another condition.
As you can see here, the Late Gad, which we used to think of as permanent, arises in about 1/3 of severe SARS patients, and seems to fade away with time.
sci-hub.tw/10.1016/j.jcmg…
It generally means that something is irritating the heart, and that cells are releasing some of their internal protein. Our tests are EXTREMELY sensitive and pick up even miniscule protein leaks.
Do you have myocarditis then?
With the blood tests all back to normal?
Others would say "Yes"
That is enough to produce a massive range of percentages-with-myocarditis.
So I don't worry about different percentages.
It is perfectly par for the course.
In science we are quite relaxed about these things.
Didn't take long for Troponin to be linked to bad outcomes in Covid.
Uncle darrel's rule
Every feature of a disease
Is a prognostic marker of that disease.
medscape.com/viewarticle/93…