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Prof Peter Hotez MD PhD Profile picture
@PeterHotez
Sep 4, 2020 • 5 tweets • 2 min read • Read on X
1/3 Thread: I was glad to see the Russians publish their phase 1 data, previously I was critical for their lack of transparency after their public declarations following licensure of "Sputnik V" or whatever the heck they were calling it. Some positives and negatives:
2/3 Thread: On positive side was their lyophilized formulation: Freeze-drying makes it possible to deliver vaccine in remote areas without a cold chain. The Russians are good at this, they pioneered the creation of "dryvax" that made it possible to eradicate smallpox in 60s 70s
3/3 Thread: Downsides: Not very high virus neutralizing antibodies, hard to compare study to study, but levels of VNA similar to Astra Zeneca vaccine in NHPs that was partially protective, also logistic complexity of 2 different vaccines for prime and boost, respectively.
I'm curious to know what might happen if they boosted instead with our recombinant protein vaccine, if that prime-boost strategy might induce higher VNAs? Not sure how we could make that happen - it certainly would be an interesting exercise in vaccine diplomacy...
Russia 🇷🇺 India 🇮🇳 USA 🇺🇸 #VaccineDiplomacy during this terrible time? That would be beyond cool, but I wouldn’t know how to begin brokering something so ambitious. Maybe @WHO @DrTedros could help us begin?

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More from @PeterHotez

Prof Peter Hotez MD PhD Profile picture
Nov 10
Another reminder: in U.S. we must now expect a regular cadence of pandemic threats: SARS in 2002, SARS-2/Covid in 2019, likely SARS-3; avian flu; Nipah; Ebola 2014, 2019; Zika 2016, soon dengue, YF. So we can’t screw around, the Trump Admin needs serious players for CDC, FDA, NIH
The Trump Administration and the Republican-led Congress must take this seriously. If we’re going to have a chance vs this onslaught of pandemic threats - and they are coming - we cannot waste time with ideologues, lightweights, propagandists, and antivaccine activists
In his first term in office: they missed the entry of the SARS-2 virus into NYC from Southern Europe bc they focused on travel from China, couldn’t organize testing and tracing, lost time and lives bc of fake hydroxychloroquine cures that didn’t work. We can’t do that again
Read 5 tweets
Prof Peter Hotez MD PhD Profile picture
Sep 24
1/n I’m concerned: the health disinformation empire has begun accelerating with this new RFK Jr GOP partnership, also worried about the muted/invisible response from our U.S. HHS agencies, health professional societies/academic health centers. Troubling pics in this thread… Image
2/n …and this Image
3/n …and this Image
Read 7 tweets
Prof Peter Hotez MD PhD Profile picture
Sep 21
1/n Tomorrow or soon, I will do a Tweet X thread on how the antivaccine, health & wellness, nutrition supplements industries joined forces with far right American politics to generate “crisis of chronic illness” propaganda. It’s an interesting story 25+ years in the making
2/n This is a slide from a PowerPoint I made years ago, looking at how the antivaccine movement has evolved (or devolved), it ends with "Chronic illness", which is really a desperation measure from the antivaccine movement after the scientific community debunked everything else Image
3/n I call it “moving the goalposts” or “whack-a-mole” and it stems from my Rachel book written in 2018. What happens is antivaccine groups make an outlandish assertion about a vaccine(s), we debunk it, and so they just make up something else, we debunk again and repeat… Image
Read 20 tweets
Prof Peter Hotez MD PhD Profile picture
Sep 17
1/n Pediatricians 'exhausted' as vaccinations drop in DeSantis' Florida.

As I sometimes say, this situation was both predicted and predictable. My papers attached. I’m so concerned about our fragile vaccine ecosystem both in U.S. and globally tallahassee.com/story/news/loc…
2/n my 2022 article in @Nature @NatRevImmunol nature.com/articles/s4157…
@Nature @NatRevImmunol 3/n my 2023 article in @Health_Affairs

healthaffairs.org/doi/full/10.13…
Read 7 tweets
Prof Peter Hotez MD PhD Profile picture
Sep 5
1/n Texas has an economy/population roughly the size of Canada. However there were 50,000 Covid deaths in Canada vs 100,000 in Texas. The reason: widespread COVID vaccine refusal in TX, 40,000-50,000 victims of a national/political health disinformation campaign. Paper attached
2/n I call this “The Great Texas COVID Tragedy” here’s my article in @PLOS @PLOSGPH written 2 years ago journals.plos.org/globalpubliche…
@PLOS @PLOSGPH 3/n Here’s the situation on Covid deaths in Canada statista.com/statistics/110…
Read 4 tweets
Prof Peter Hotez MD PhD Profile picture
Aug 25
My goodness what’s happening at @Stanford? This is awful, a full on anti-science agenda (and revisionist history), tone deaf to how this kind of rhetoric contributed to the deaths of thousands of Americans during the pandemic by convincing them to shun vaccines or minimize Covid
The program indicates the new Stanford President will headline the symposium. While I’m all for free speech, this type of anti-science aggression doesn’t have to be promoted by the Stanford leadership, given the chilling message it sends to the serious science faculty/students
Therefore I hope the Stanford President reconsiders and instead focuses his attention on the important scientific projects underway on his campus, and not this nonsense
Read 4 tweets

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