1/ Another result of the collaborative effort, Coalition Covid-19 Brazil, is out!
Kudos at this time to HIAE trial coordination: Otavio Berwanger & Remo Furtado, not on twitter 😕 @JuliaMachline #COVIDー19 @TheLancet @f_g_zampieri @a_serpaneto @FlaviaSepsis @azevedo_lcp
Kudos at this time to HIAE trial coordination: Otavio Berwanger & Remo Furtado, not on twitter 😕 @JuliaMachline #COVIDー19 @TheLancet @f_g_zampieri @a_serpaneto @FlaviaSepsis @azevedo_lcp
2/ Here the population included in the trial, note that about half of pts were on IMV, ~1/4 shocked. Steroids were being administered to only 15-20% (at that time, early on in the pandemic, steroids were not known to benefit severe covid-19 pts)
3/ At day 15, the use of azythromycin 500mg/d for 19 days did not change health status, look at death (6) and IMV (5) or discharged pts (1)
4/ Adverse events were not different between groups. Note that pts using other drugs known to prolong QT were excluded and daily EKG w dose modification was part of the protocol (meaning: be careful when extrapolating trial data to the real world)
5/ Bottom line, azithromycin does not seem to benefit severe Covid-19 patients.
Congrats to all involved!!!!
Congrats to all involved!!!!
6/Correction: Azihtromycin 500mg/d for 10 days
