Innate immunity - the strong and fast first layer of our immune response.
Only minutes after entering our body, most -up to 90%- of pathoges are cleared by this "archaic" system.
Endeless-🧵⬇️
(to be updated from time to time)
Only minutes after entering our body, most -up to 90%- of pathoges are cleared by this "archaic" system.
Endeless-🧵⬇️
(to be updated from time to time)
Innate immunity destroys structures that are alien to the human organism.
It´s always there, in contrast to B-Cells (Antibodies) and T-Cells it is *not* adaptive.
It does not depend on learning, but on finding structures that are typical of intruders.
🧵↕️
It´s always there, in contrast to B-Cells (Antibodies) and T-Cells it is *not* adaptive.
It does not depend on learning, but on finding structures that are typical of intruders.
🧵↕️
Covid19 is a ssRNA Virus with an envelope and a Spike Gylcoprotein, so it has some parts that are very different from human cells.
It should be a rather easy target for innate immunity.
Let´s have a look on some players of this arachaic system in this thread
🧵↕️
It should be a rather easy target for innate immunity.
Let´s have a look on some players of this arachaic system in this thread
🧵↕️
1. PAMPS/ Toll like receptors
Basic principle: typical viral RNA or Glyoproteins are recognized, target destroyed. Does this play a role in Covid19? Yes.
Case report of a mutation in TLR7 that leads to very severe illness in 4 young patients
jamanetwork.com/journals/jama/…
🧵↕️
Basic principle: typical viral RNA or Glyoproteins are recognized, target destroyed. Does this play a role in Covid19? Yes.
Case report of a mutation in TLR7 that leads to very severe illness in 4 young patients
jamanetwork.com/journals/jama/…
🧵↕️
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