1/Two things: Given the lack of t cell infiltrates, is this due to a lack of MHC expression on the surrounding cells? This stain should have been done as a mechanistic enquiry, I know canonically neurons do not express it but there is cross presentation by surrounding cells.
2/Perhaps it was and I read it wrong. Unknown; and wondering if the other viruses mentioned also have the leukopenic phenotype this does. The dying people aren't typical cases- there could be reasons they failed to have immune inflitrates, but the finding is significant and
3/concerning.
Also, adverse event in chadox- could it be that infected who did not seroconvert passed through the first sieve by testing neg for antibodies and were enrolled in the trial, received the vaccine, and it primed the cells again and cleared out remaining antigen in the
Also, adverse event in chadox- could it be that infected who did not seroconvert passed through the first sieve by testing neg for antibodies and were enrolled in the trial, received the vaccine, and it primed the cells again and cleared out remaining antigen in the
4/ cns? worth a thought. Figures a leaky efficiency would punish us in that way- need to absolutely rule out prior infection for such studies.
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