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AJ Leonardi, MBBS, PhD Profile picture
AJ Leonardi, MBBS, PhD
@fitterhappierAJ
Less than nothing. Former @riteaid cashier. Immunology aficionado (of my own ideas) 😷N95❤️‍🔥 Caremonger Hated by Infection-based immunity proponents Views own
pnwarrior_womyn Profile picture Janet Mathis Profile picture Denise Redon 🇺🇸 Profile picture Brad Barrish Profile picture Wayne L Pendley Profile picture 60 subscribed
Jun 22 • 4 tweets • 1 min read
@Bryce_Nickels This is absolutely false because he made a “noble lie” and said the N 95s would not work for the public to the public in order for there to be greater supply to healthcare workers only. This backfired. @Bryce_Nickels The ethical approach was the truth. This is a similar noble lie by omission that the WHO made when they refused to declare Covid as airborne in order for impoverished health systems to provide “adequate” PPE per their regulations according to WHO standards
Apr 6 • 4 tweets • 1 min read
When will H5N1 will go Human to Human? Which is deadlier?
Mar 29 • 4 tweets • 2 min read
I think the decrease in childrens performance following 2020 was due to the Neurological harm after they were coaxed into unsafe classrooms before vaccination

I think this will remain the dominant effect due to Covid's neurotropism on reinfection

theconversation.com/mounting-resea… Some people are encouraged to obfuscate the risk of kids getting infected and they will continue to do so


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Jan 26 • 5 tweets • 2 min read
I was a fellow at the National Cancer Institute for 4 years in immunotherapy of cancer

They paid for my PhD

I am happy to explain hypotheses for a potential SARS Cov 2 based increased risk of cancer:

1/4 There are multiple ways a virus can cause cancer directly & indirectly

One indirect way is by tempering immunity

The immune system surveils for wayward, cancerous, and precancerous cells, and kills them

SARS Cov 2 ages & dysregulates T cells
2/4
Jan 24 • 10 tweets • 3 min read
In 2021 on TWIV, Vincent Raccaniello said my claims of T cell exhaustion risk were "Twitter Science™"

In 2024 I am pleased to see T cell exhaustion is Science™, Nature Immunology™, and Nature Medicine™ Science Raccaniello is arrogant enough to the extent to reject an accurate scientific hypothesis on twitter and his TWIV podcast to the detriment of the public, without knowing enough about the subject It was completely irresponsible

Jan 23 • 4 tweets • 1 min read
Massachusetts General Hospital has declared a critical incident under a "capacity disaster"

Some professors at Harvard assured the crisis phase of covid was over.

I sure would be embarrassed if shown up by someone I keep proclaiming superiority over.

patch.com/massachusetts/… Especially if I was a wunderkind Harvard professor in Cardiology.

That would mean I know at least as much immunology as a professor of immunology at a state school
Jan 15 • 5 tweets • 2 min read
Many people are discovering the paradox of how T cells are driving the harm- pathology- in covid-19

This was part of my publication in 2020, I gave the opinion that T cell effector function was harming organs and that it would remain significant on reinfection
Image Can you all appreciate how much I was attacked for saying the T cells were harming and responsible for harm? It was relentless. Every Professor with Dunning Kruger went on attack-mode.
Jan 9 • 5 tweets • 2 min read
People rightfully chafe when sars cov 2 is compared to HIV

The problem is you have allowed denialism to dominate public discussion

When you deny the obvious, you create a vacuum that can be filled with conspiracy theories

4 papers show infection of T cells by SARS 2
1/5
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Image Even though this is well-published in nature family journals and eLife, empty suits that promised herd immunity by infection deny such a thing is possible.

I am talking about Marc Veldhoen and Antonio Bertoletti

We can see the profound lymphopenia that can occur
2/5
Oct 23, 2023 • 11 tweets • 4 min read
As we are hit with yet another Covid wave, I want to reflect on the promises of herd immunity by infection, with special consideration of claims that pre-existing cross-reactive T cell immunity to other coronaviruses was aiding in achieving the herd-immunity threshold These two circumstances are not unrelated. The reason we are having constant reinfection with sars cov 2 is because we gave the virus the keys to the kingdom: enough replication to enable evolution to escape key parts of our immune systems
Oct 14, 2023 • 10 tweets • 5 min read
Since 2020 I have claimed that sars cov 2 infection would create harmed t cell memory based on phenotypes after infection

It is now proven

Even so, I have several Professors who pretend to not understand or do not understand how, nipping at my heels

I assume they behave this way because they are tenured & very mad, so they feel they can put their ignorance and vitriol on display wantonly

Bertoletti even made a nod to me in a publication, which the journal maintains references me in no way whatsoever


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Sep 15, 2023 • 5 tweets • 1 min read
1) Senior immunologists said I was wrong that infections posed the risk of widespread T cell exhaustion and called it "twitter nonsense"

2) They said I was wrong that the experience in severe disease shared the spectrum of mild disease, despite sharing mechanism 3) They said I was wrong about Fas-mediated apoptosis

4) They said I was wrong that reinfections would continue to hyperactivate T cells

5) They said I was wrong about the prospect of rapid evolution and antigenic escape
Aug 4, 2023 • 6 tweets • 2 min read
The virus has not turned into an ordinary illness

Symptoms are from the immune response and appreciated grossly (eg cough, chills, headache, fever)

Pathophysiology tells a different tale of effects Cov2 has that ordinary illnesses don't

🧵 For example, even extreme lethal cases of flu do not send T cells into the brain

SARS Cov 2 does

https://t.co/gxSHkoJ5Z1nature.com/articles/s4158…
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Jun 10, 2023 • 7 tweets • 4 min read
The claim Long Covid rates would reduce upon reinfections were made by Iwasaki, Zeynep, and others

When I said I believed the opposite I was derided and mocked

Three studies now show increasing rates of Long Covid on reinfection

🧵

ImageImageImageImage I was mocked as not a subject matter expert by the established in the field like Rupert Beale. Zeynep would tag 15+ immunologists below me

Before I was mocked as "not Galileo" because I claimed there would be no herd immunity to Covid before Omicron
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Jun 4, 2023 • 6 tweets • 1 min read
Hello

I am the only person who said there would likely be increased rather than decreased rates of long covid upon reinfection due to cumulative effects on the immune system and organs

Several studies recently corroborated this Recently, I made a statement that lifetime rates of long Covid would be over 99.9%.

Most people erroneously took this as a Percentage of the population affected, which it would not be

Some people would get long Covid several times others, not at all
May 28, 2023 • 8 tweets • 2 min read
Both Ladhani's and the NIH's Long Covid studies show the idea that Long Covid probability goes down with reinfection because your "immune system fortifies with exposure" is false

This was yet another piece of wishful thinking that I stood against

nytimes.com/2022/08/12/opi…
1/7 Image You may remember when reinfections were claimed unlikely, and immunity would be lifelong similar to SARS 1

I claimed it was possible sars2 would mutate quickly out of it

This is yet another example of being overly optimistic and not accounting for facets of sars cov2

2/7
May 27, 2023 • 5 tweets • 5 min read
All throughout medical school, I have faced Marc Veldhoen and Bertoletti calling me things from "depressed" to "grifter," and mocking me for stating that SARS Cov 2 infection can cause T cell harm

Here Zeynep Tufekci acknowledges the article is pointed at my "looney" theories ImageImageImageImage If the investigation finds that the "fit and happy" title has nothing to do with a directed critique against me, it will have been a sham ImageImageImageImage
May 26, 2023 • 4 tweets • 3 min read
Risk of long covid accumulates via reinfections if the graph is assumed to be correct, meaning it is not one group of susceptible people as others have said

The new LC studies corroborate a cumulative model versus susceptible model of Long Covid risk ImageImage The "susceptibles" model of Long Covid was harmful to patients with Long Covid AND incorrect

It postulated that people with LC had some genetic susceptibility for their problem, and this effect would not be seen in the wider population

It's shown false
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Apr 14, 2023 • 4 tweets • 3 min read
The United States is declaring war on Women

Restricted access to the Mifepristone and other medical services means women risk carrying more unsafe and nonviable pregnancies

In my opinion, restricted access is motivated by special interests that want more laborer births Image The cost of labor & inflation are skyrocketing

Forcing pregnancies to term expands the pool of laborers & could be construed as an attempt to rectify the screw-up that special interests made when forcing people to be reinfected by a disabling virus in pursuit of herd immunity Image
Apr 14, 2023 • 4 tweets • 1 min read
There are enough publications about how the Autoantibodies made from infection are not happening from the vaccines, including mRNA vaccines

The people trying to blame harm on the vaccines are covering for the effects of mass infection The people claiming infection does not cause autoimmunity, T cell harm, or T cell mediated harm are enabling those who would blame this on the vaccines
Apr 13, 2023 • 5 tweets • 2 min read
Good news for the vaccinated

When breakthrough infection does occur, the T cells work quickly

HOWEVER, the advantage in viral clearance is for the vaccinated, NOT the previously infected according to the discussion
cell.com/immunity/fullt… Again, this advantage is in contrast to the people who are simply having a reinfection Image
Apr 11, 2023 • 4 tweets • 2 min read
This is a fantastic example of adapting to the science

Originally this article was about how variants were NOT further adapting to escape T cell immunity

Omicron changed that

Cov2 is getting better at thwarting CD8 T cell immunity Image I thought we would see better T cell evasion with evolution

Happy to see this one work out