Matt Hall Profile picture
13 Sep, 4 tweets, 2 min read
Well - huge issues here. Not sure this article will be around for long.

And it's just samples collected for a completely different study (on asthma), and they checked TMPRSS2.

"Race" isn't mentioned in the awarded R01 - it's an asthma grant from NIAID.…
I have a terrible feeling that ran TMPRSS2 expression on their samples, looked for a differential based on what they know about study sample donors (rather than having a hypothesis), and were like "welp, 'race' is a thing with COVID let's go with that".
I mean, there are enough studies showing this approach is not valid:

"These results suggest that .... careful consideration of self-identified race in gene expression profiling studies is needed to avoid spurious association."…
There are whole books we all need to read:…

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More from @cispt2

5 Apr
OK so let's talk about camostat, because I'm starting to worry about it as a #COVID19 repurposing candidate. It emerged based on this Cell paper, but a LOT of assumptions are buried in the science.… Image
That Cell paper calls camostat "calls camostat “a clinically proven inhibitor of the cellular serine protease TMPRSS2” – which is not strictly correct.

It’s a clinically used drug (in Japan)

It has been shown to act on TMPRSS2 indirectly

Separate points. @Dereklowe
So what is camostat used for?

It's a serine protease inhibitor, and in Japan it's approved for treating pancreatitis. In that indiciation, doses are 600 mg are given. Data indicates it acts via anti-inflammatory action:…
Read 14 tweets
30 Jan 19
This article on a 'miracle cure' for cancer has me so angry. How can unpublished, non-peer reviewed tripe get any attention at all? Some of the issues are in the thread below:…
First, the experimental theraputic modality is based on phage-display-derived peptides against various targets that are apparently coupled together with a 'peptide toxin'. Presumably the peptide toxin is Monomethyl auristatin E
Next, the article states they have "concluded its first exploratory mice experiment, which inhibited human cancer cell growth and had no effect at all on healthy mice cells".
Read 11 tweets

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