Dr. Ali Nouri Profile picture
Sep 15, 2020 11 tweets 5 min read Read on X
In case there's doubt that the virus can spread through respiratory particles that float in air and travel far, I wanted to share these studies:

1. Indoor airborne event: plant worker transmits virus to those 24ft away in area w/re-circulated air 1/n
papers.ssrn.com/sol3/papers.cf…
2. Super-spreader at choir: of 27 participants, 70% diagnosed w/COVID-19; 36% hospitalized; 21% ICU.

It was indoors w/no ventilation. Spread was likely through both big droplets that fall to the ground & airborne aerosols that float 2/n
medrxiv.org/content/10.110…
3. JAMA: super-spreader infects 23 on bus: "Airborne spread of SARS-CoV-2 seems likely to have contributed to the high attack rate in the exposed bus" The AC unit was set to "re-circulation mode" 3/n
jamanetwork.com/journals/jamai…
4. CDC: Another choir super-spreading event: following practice, 32 confirmed; 20 probable secondary cases. "The act of singing, itself, might have contributed to transmission through emission of aerosols, which is affected by loudness of vocalization" 4/n
cdc.gov/mmwr/volumes/6…
5. Coronavirus is in the air: 94 employees (out of 216) were infected in a call center in South Korea, a 43.5% attack rate! Nearly all of them sat on the same side of the building, suggesting airflow as culprit 5/n
wwwnc.cdc.gov/eid/article/26…
6. Another study pointing to coronavirus in the air: an asymptomatic individual sitting at a table in a restaurant infected people sitting at two other tables that were facing an Air Conditioning unit, pointing to recirculated air as the culprit 6/n
wwwnc.cdc.gov/eid/article/26…
7. NATURE: virus captured from aerosols: Aerosols emitted by SARS-CoV-2 patients contain the virus and the virus can infect cells 7/n
nature.com/articles/s4159…
8. Another study shows viable SARS-CoV-2 captured from air samples, this time 2-5 meters away with COVID-19 patients. Virus is stable and in respiratory aerosols that can float far. 8/n
medrxiv.org/content/10.110…
9. CDC: Virus is stable in air: once airborne, SARS-CoV-2 retains ability to infect for at least 16 hrs. It's hardier in aerosols than SARS-1 or MERS

This helps explain why airborne route could be major culprit 9/n

wwwnc.cdc.gov/eid/article/26…
10. Scientists have been saying this for a long time.

@DrLaPook to @kprather88:How sure are you that the virus is significantly spread through aerosolization? 10/n
11. But US and WHO officials have been slow to update guidance.

In contrast, the National Health Commission of China highlighted the possibility of aerosol transmission 6 months ago! 11/n

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More from @AliNouriPhD

Dec 3, 2024
🧵 1/5 New @NatureMicrobiol study reveals H5N1 bird flu evolution: Scientists measured infectious virus particles in air from infected ferrets, finding recent strains show low but increased ability to be expelled into air compared to older variants. Image
2/5 Key finding: While 2005 H5N1 showed no infectious virus in air samples, recent strains from a European polecat (2022) and US dairy worker (2024) showed limited infectious virus shedding in air from single ferrets. This matches their observed limited transmission patterns.
3/5 The adaptations seen (like PB2-E627K in the dairy worker strain, PB2-T271A in polecat strain) may enable higher replication, allowing some air shedding despite the virus still preferring avian-type receptors. But efficiency remains much lower than human flu viruses.
Read 5 tweets
Aug 27, 2024
1/New study on how Clade 2b Mpox spreads between people👇

Note: this is a different clade (subtype) from more recent outbreak caused by Clade 1b which is more lethal (more on clade 1b later)

Now back to Clade 2b: from 2022-24 it spread to >100 nations
wwwnc.cdc.gov/eid/article/30…
2/The outbreak was driven by human-to-human transmission via close contact with infected persons; most cases among men who have sex with men.

However: the new study (albeit small sample size) points to infection from contact with skin lesions as higher risk than from semen.
3/Researchers looked at Mpox G2R-mRNA activity which is an indicator of replicating virus. They found high activity (more virus replication) in lesions, but much lower activity (in some cases non existent) in semen, suggesting that this biologic fluid could represent minor route.
Read 5 tweets
Nov 6, 2022
According to CDC 1 out of 5 who are infected with SARS-COV-2 develop Long Covid.

New report by @zalaly using @DeptVetAffairs data found taking Paxlovid is associated with a 25% decrease in #LongCovid: rb.gy/vnwitj

A thread on how Paxlovid💊neutralizes the virus👇 1/5
2/The SARS-CoV-2 virus is made up of components (proteins, RNA, lipids) that come together and give rise to functional virus particles. Paxlovid blocks the ability of some of the proteins to function, resulting in a defective virus. Here's how…
3/Normally, when the virus infects cells, its RNA genome replicates, the RNA is turned into proteins, & proteins come together to make new viruses.

When the proteins are made, they're  initially strung together, but they need to be freed from one another in order to do their job
Read 5 tweets
Oct 31, 2022
Big news from @ENERGY:

Electric Vehicle battery & grid battery supply chains are coming to the USA 🇺🇸

$2.8 Billion in awards to support 20 companies to manufacture domestically

This is 1st of set of investments to build out battery manufacturing

A thread on projects👇1/22
2/22

Albemarle: project objective to construct new, commercial-scale U.S.-
based lithium materials processing plant at Kings Mountain, North
Carolina that uses sustainably extracted minerals from the site’s lithium mine.
3/22

American Battery Technology Company: commercial-scale facility to manufacture battery cathode lithium hydroxide from Nevada-based lithium-bearing sedimentary resources.
Read 22 tweets
Aug 15, 2022
The Inflation Reduction Act Congress just passed includes a historic $369 billion investment to 1) lower energy costs; 2) revitalize US manufacturing; 3) slash greenhouse gasses by 40%; and 4) address environmental justice. Here are a few highlights from this bill🧵 Princeton REPEAT Project
1. Lowers energy costs for consumers:

Includes rebates to install electric & low emission appliances in homes

Also includes tax credits to make homes energy efficient, install solar, geothermal, etc...

$7,500 consumer credit to purchase clean cars like EVs; $4K for used🚘
2. Supports nationwide clean energy manufacturing base

Tax credits for manufacturers of clean energy technologies

Grants and loans so auto makers can retool & produce clean cars, like Electric Vehicles

Funds R&D @ENERGY National Labs to develop next-gen energy technologies
Read 6 tweets
Jul 18, 2022
1/Early diagnosis, isolation & contact tracing of close contacts are key to controling the Monkeypox outbreak.

Here are the European Union health authority's recommendations for who should be contact traced during this outbreak: the four categories of "close contacts" include:🧵 Image
2/

🔹️Sexual partners: those with any type of sexual contact with MPX cases from the onset of symptoms

🔹️Household contacts: those living in same household (inc. overnight camping/stay) with MPX cases; those sharing clothing, bedding, utensils; or caregivers of MPX cases Image
3/

🔹️Health workers coming into contact w/patient's lesions or w/prolonged face-to-face contact (>3 hrs at < 2m distance) or involved w/aerosol generating procedures—all without PPE

🔹️Other: case-by-case, may include those sitting next to MPX case during prolonged travel Image
Read 4 tweets

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