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F. Perry Wilson, MD MSCE Profile picture
@fperrywilson
Sep 16, 2020 • 4 tweets • 3 min read • Read on X
I have no idea which #vaccine
@realDonaldTrump was talking about today. But if we are going to have a vaccine before 2021, it will be one of these seven.

Here are the details (THREAD)

methodsman.com/blog/current-c…
mRNA vaccines
Inactivated virus vaccines
Adenovirus vector vaccines

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More from @fperrywilson

F. Perry Wilson, MD MSCE Profile picture
Dec 1
We're in the middle of a quiet revolution in depression treatment. For decades it was all about "chemical imbalance". SSRIs tweaking serotonin levels. And they work. Sort of.
(Thread)-->
(1/18) Image
Problem is, SSRIs take weeks to kick in. When someone's severely depressed, time matters. And 30-50% of patients don't get adequate symptom control anyway. Not great numbers. (2/18)
Enter the glutamate pathway and a new class of agents: ketamine, psilocybin, and now... nitrous oxide. Yes, the dentist gas. Or the whippits gas I guess.
(3/18) Image
Read 18 tweets
F. Perry Wilson, MD MSCE Profile picture
Apr 8
The fact that GLP-1 receptor agonists (like Ozempic and Mounjaro) are the most powerful weight loss drugs ever is NOT the most interesting thing about them. More stuff keeps coming out - and the effects are just wild. This week? A reduction in dementia risk. Breakdown below. Image
This week, for @medscape, I reviewed this article, appearing in @jamaneurology. It's the first real meta-analysis of the effect of glucose-lowering drugs on dementia focusing solely on randomized trials. buff.ly/J5PXkL8Image
@Medscape The background here is that the SGLT2-inhibitors, pioglitazone, metformin, and the GLP-1 receptor agonists have all been shown to protect the heart in diabetes. Would they protect the brain as well? The problem is that these trials were not designed to identify dementia.
Read 11 tweets
F. Perry Wilson, MD MSCE Profile picture
Mar 18
The GLP-1 receptor agonists (like Ozempic and Mounjaro) are wildly effective weight-loss agents. But are they COST-effective? That's a trickier question. And a new study just out in JAMA Health Forum provides an answer. A resounding "no."
(Thread) Image
For those of you who like reading articles in the traditional way, please check out my weekly column @Medscape. Good comments there too.
buff.ly/4IhGleH
@Medscape I tend to evaluate a drug in terms of efficacy or effectiveness, not cost-effectiveness because I, like most doctors, find it incredibly difficult to know what a drug I may prescribe actually costs (yes, it's ridiculous. Yes, it's true)
Read 23 tweets
F. Perry Wilson, MD MSCE Profile picture
Feb 25
If you were on social media during the pandemic, you came across #DiedSuddenly.
Stories of young people, healthy, suffering fatal cardiac arrest out of nowhere. The implication? Those evil vaccines.
It was all bullshit. But I want to talk about why it was so effective.
🧵 Image
Before we dive in, I have a bit longer version of this thread @medscape: buff.ly/4keHNvW
@Medscape The reason I was thinking about this issue this week was because of this study, just published @jamanetworkopen, examining the rate of sudden cardiac arrest and sudden death in middle school, high school, and college athletes. buff.ly/4bkqcPkImage
Read 15 tweets
F. Perry Wilson, MD MSCE Profile picture
Feb 8
NIH has announced a cut in the "indirect rate" to 15% across the board, in a move that appears to be retroactive to even existing grants. This is a bloodbath for research institutions throughout the country.
Brief explainer for those not in this world:

buff.ly/3EtML7D
If I am awarded a grant for the NIH, it covers my budget for the research study. It ALSO awards a percentage of that budget (over what I need for the study) to Yale, my institution. That overage is called the indirect rate.
This money is used to pay for office space, electricity, internet, library, journal subscriptions, administrators, printer paper, etc. This stuff is EXPLICITLY not allowed in the main budget for a research study. I can't budget for printer paper. That is all in the "indirects".
Read 10 tweets
F. Perry Wilson, MD MSCE Profile picture
Feb 4
This thing keeps happening with ultra-processed food research and it's very confusing to me. People seem to be searching for a link with bad health outcomes that is *independent* of caloric intake. Like... folks... that's the link. (brief 🧵) Image
I think I got on this kick with the JFK hearings. There was... a lot there. His thoughts about UPF actually come close to the mark though. Except he did this thing that a lot of people do - he blamed the health outcomes of UPF intake on the chemicals and additives and stuff.
The reason that's dangerous is the implication that if we got rid of that stuff, the food would be better for us. Like Doritos without preservatives would be good for us or something. It's really not true.
Read 14 tweets

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