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F. Perry Wilson, MD MSCE Profile picture
@fperrywilson
Sep 16, 2020 • 4 tweets • 3 min read • Read on X
I have no idea which #vaccine
@realDonaldTrump was talking about today. But if we are going to have a vaccine before 2021, it will be one of these seven.

Here are the details (THREAD)

methodsman.com/blog/current-c…
mRNA vaccines
Inactivated virus vaccines
Adenovirus vector vaccines

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More from @fperrywilson

F. Perry Wilson, MD MSCE Profile picture
Jul 30
Data keeps emerging that suggests GLP-1RAs like #Ozempic curb all sorts of appetites... not just appetite for food. Brief thread on some new findings...
They aren't the splashiest articles, but studies keep suggesting Ozempic has these "off-target" effects. Here's one showing the drug reduces alcohol intake...
nature.com/articles/s4159…
And here's one on how it improves cannabis use disorder...
nature.com/articles/s4138…
Read 21 tweets
F. Perry Wilson, MD MSCE Profile picture
Jul 8
Well we finally got an Ozempic vs. Mounjaro head-to-head (kind of)... Brief thread to break down the weight-loss-drug showdown...
Appearing today @JAMAInternalMed, we have this study, which is probably the closest we'll get to a semaglutide (Ozempic), tirzepatide (Mounjaro) randomized trial. (See my article @medscape for why we almost never get real trials of competitor drugs).
medscape.com/viewarticle/mo…
Image
This is a propensity-matched cohort study from @truveta - shout out to CTRA alum @SimonovSays - I'm sure you were behind the scenes on this.
Prior trials actually suggested that Mounjaro was a bit more effective than Ozempic... but there is an apples-to-oranges problem. Image
Read 12 tweets
F. Perry Wilson, MD MSCE Profile picture
May 14
This week, we have an interesting article in @JAMA_current which finds that adding three biomarkers that are clearly associated with cardiovascular disease to an existing risk equation does NOT improve the predictive ability of that equation. How does this happen?
🧵
I want to take a minute to try to break our intuition that strength of association and strength of prediction are the same thing (or even necessarily related). An an example, I made up some fake data.
We have 10,000 people, followed for 10 years. 2000 Die. (Yikes). Image
At baseline, I measured a biomarker - called "Perry Factor" in everyone. It's a simple marker - in fact it only has two values, 0 and 1.
Read 25 tweets
F. Perry Wilson, MD MSCE Profile picture
Feb 21
I've definitely noticed this phenomenon in American diet culture of late.
But high-protein diets may not be all they are cracked up to be. Why? A new study in Nature Metabolism puts the blame squarely on a single amino acid: leucine.
🧵 Image
OK there are three macronutrients. Your caloric intake will be comprised of some combination thereof, and basically all of the diet wars of the last 40 years can be cast in terms of macro content. Image
When I was growing up (it was a time called the 80s. Thing were... interesting) low-fat was the crazy. Remember "fat makes you fat"?
Read 20 tweets
F. Perry Wilson, MD MSCE Profile picture
Jan 9
Does it seem like your hospital patients are getting more... complicated? They are!
🧵 Image
Just went through this paper from @JAMAInternalMed which, like all good papers, comports with my prior beliefs ;-). No but seriously, I definitely feel like hospital complexity is rising. Image
Data comes from British Columbia - good for 2 reasons.
1) Universal EHR so you capture all hospital admissions
2) Universal healthcare - so you don't need to worry as much about access issues, etc.
Read 10 tweets
F. Perry Wilson, MD MSCE Profile picture
Nov 14, 2023
I believe that RNA therapeutics will completely transform medicine. Imagine a future where, instead of taking medications daily, you take a shot maybe once a year. That future is, basically, here.
🧵
Currently, this is more or less how our drugs work. They do something to a protein. Inhibit it, cleave it, block its binding to some receptor, speed its degradation, etc. Image
And, if you really think about it, disease is mediated by proteins. High cholesterol? Protein problem. Sepsis? Proteins. Viral infection? Viruses hijack our cells to make their... proteins.
Read 22 tweets

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