For long I wanted to do a funny thread to show you some beautiful and a few slightly bizarre things I encounter on my daily #bikeride to work at @ISTAustria.
Today sth happened and I realized I could no longer do it.
My way to work is just a few km, perfect distance to relax the mind after a long day without exhausting myself. most of it on bike paths, beautiful nature.
For the short distance, there is a remarkable amount of memorial plaques, miniature chapels and other landmarks that I pass by every day.
Since recently there even is a pale ghost lady statue sitting in a private garden, just before I reach the institute. I’d be curious to know why someone would put up this kind of statue. It is not without beauty, but I find it creepy.
All together it looks like the perfect bike-to-work route. Except that it isn’t.
If I bike with my little daughter on the back seat to take her to kindergarten, there’s a tricky part right at the beginning, in the center of Klosterneuburg.
I tried a few things, but there is no real alternative to using the main road where cars rush to catch the green lights. Whenever I go there I feel just slightly uncomfortable, and hope the car drivers have their eyes on the street.
A few days ago, I learned that this summer, a 56 year old lady died on her bike, in that very spot.
She was going straight down on the main road, just as I do with my kid on the back seat, when a car entered the crossing from the right, ignoring a STOP sign, hit her, and gave her deadly injuries.
A day later, I learned that the anonymous lady had been the midwife I used to go for postpartum exercise with my other daughter.
I remember her as a very grounded, direct and warm-hearted woman. She used to live and work right below the crossing that became the place of her death, about the same distance from the spot as we live away from it.
Today, I learned that the @radlobby_klbg had been repeatedly pushing to open an obvious alternative route, to avoid that cyclists have to take the main road. radlobby.org/noe/toedlicher…
Just a year ago, there had been a petition for safer bike routes for high school students that included the same recommendation.
All pushes and petitions were declined because of “loss of parking spots”.
Now, the 56 year old midwife is dead and I feel deeply sorry for the loss and pain of her family. Knowing, it might as well have been me and my three year old who got killed. And now, our bike would be the white #ghostbike at that corner.
It didn’t have to be like this. Unsafe roads are not a law of nature. Let’s do better. So this ended up not being a funny thread about my commute to work. but maybe this is more the kind of thread that we need.
Aftertweet: that spot is actually not the only dangerous spot on the route. At least one more, in Kierling, is really bad too, except that I don’t know of anyone who died there, yet. It even has a bike crossing, but like 3 in 4 car drivers don’t care.
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Jetzt haben wir sie also, die ersten Neutralisationsdaten. Dabei wird im Labor untersucht, ob und wie gut Antikörper im Blut von Geimpften oder Genesenen Omikron “abfangen” können.
Kurze Erklärung, was am Bild zu sehen ist und was das bedeutet:
Auf der x Achse links das quasi ursprüngliche Virus von Frühling 2020 (D614G), rechts Omikron. Auf der Y Achse, in logarithmischer Skala (jeder Schritt eine Zehnerpotenz), wie stark man das Serum der Menschen, in dem die Antikörper schwimmen, verdünnen kann,
sodass das Virus noch abgefangen wird. Je höher die Werte, desto mehr kann man verdünnen, was bedeutet, dass die Antikörper besser am Virus kleben bleiben (hoch=gut). Die orangen Linien verbinden jeweils zwei Punkte von einem doppelt mit Pfizer/Bnt geimpften Menschen,
3 gute Nachrichten zu omikron (ja, es gibt sie!): 1) es ist leicht festzustellen 2) Antigentests schlagen darauf an 3) wir dürfen auf weiter guten Schutz durch Impfung vor schwerer Erkrankung(!) hoffen.
Alle drei haben eine Sache gemeinsam … 🧵
… sie alle lassen sich im Licht eines fundamentalen biologischen Funktionsprinzip auf molekularer Ebene verstehen: die Bausteine des Lebens gewinnen erst durch ihr gegenseitiges räumliches Zueinanderpassen ihre Funktion. Klingt kryptisch, ist es nicht.
Die Bausteine, über die wir reden, Proteine und ähnlich auch Nukleinsäuren (DNA/RNA) sind Riesenmoleküle. Sie haben eine 3D-Form mit Beulen und Mulden, sind ständig in Bewegung, und in erster Näherung „leicht klebrig“ an der Oberfläche.
Warum macht uns Omikron gar so große Sorge, woher wissen wir, was wir wissen, warum ist das noch nicht sehr viel, und warum werden wir sicher bald mehr wissen? 🧵
Erst mal: Das Risiko einer Variante hat drei Dimensionen– Transmissibilität, Immune-escape und Virulenz.
Und dann: Es gibt zwei Wege, das Risiko, das eine neue Variante birgt, abzuschätzen. Bottom-up und Top-down.
1) Bottom-up: man beginnt mit der Molekularbiologie, sieht sich die Sequenz bzw die vorliegenden Mutationen an und vergleicht mit bisherigen Mutationen und deren Auswirkungen.
"But if Czechia is doing so much worse than we in Austria, how come we don't hear horror stories from overcrowded hospitals or morgues?"
Is it all not so bad? Or are we just not hearing about it?
I did a back-of-envelope calculation to get an idea. #ICUs#Czechia 1/
/// So instead of going to sleep I spent last night doing this calculation and the results were pretty terrible. I think it's important but because it is so important I decided to put in a bit more time and have it checked by critical friends.
So I took the original thread down. Once I'm done with review, I'll bring it back up here, promised. Especially when results are harsh, I'd like to stick to how science works. First peer review, then sharing with the public. Thanks for your understanding!
With my partner's family in Czechia, I keep an eye on their situation. No substitute for a proper analysis, but here's my personal perspective as a mum of kids, separated from their grandparents not by an iron curtain, but by a toxic atmosphere of public distrust. 1/n
I started to worry in late summer, when our family would happily send pictures of full indoor concert halls, family parties (we declined), and indoor gatherings. With very low numbers, everyone felt it was over. Remember the false sense of security in Austria? Take that times 10.
The wrong sense of safety was exaggerated by the narrative of the government that their hard spring response was what had brought them into a winning position. (Guess who needed to win an election in October.)