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AJ Leonardi, MBBS, PhD Profile picture
@fitterhappierAJ
Sep 19, 2020 • 5 tweets • 2 min read • Read on X
After infection you lose A LOT of your naive T cells. Then, not having naive t cells predisposes you to baad outcomes the second go around. I've been saying it. cell.com/cell/fulltext/… Image
cell.com/cell/fulltext/…

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More from @fitterhappierAJ

AJ Leonardi, MBBS, PhD Profile picture
Apr 6
When will H5N1 will go Human to Human?
Which is deadlier?
"The Covid pandemic has prepared me for an H5N1 pandemic"
Read 4 tweets
AJ Leonardi, MBBS, PhD Profile picture
Mar 29
I think the decrease in childrens performance following 2020 was due to the Neurological harm after they were coaxed into unsafe classrooms before vaccination

I think this will remain the dominant effect due to Covid's neurotropism on reinfection

theconversation.com/mounting-resea…
Some people are encouraged to obfuscate the risk of kids getting infected and they will continue to do so


Image
Image
16.1% of reinfected children got Long covid after reinfection compared to 12.1% with only 1 infection

More reinfected individuals had persistent anosmia, an indicator of neuroinflammation
ncbi.nlm.nih.gov/pmc/articles/P…
Image
Read 4 tweets
AJ Leonardi, MBBS, PhD Profile picture
Jan 26
I was a fellow at the National Cancer Institute for 4 years in immunotherapy of cancer

They paid for my PhD

I am happy to explain hypotheses for a potential SARS Cov 2 based increased risk of cancer:

1/4
There are multiple ways a virus can cause cancer directly & indirectly

One indirect way is by tempering immunity

The immune system surveils for wayward, cancerous, and precancerous cells, and kills them

SARS Cov 2 ages & dysregulates T cells
2/4
A second broad yet direct category is by Viral Oncogenes or mutagenesis

Some Viruses have proteins that can change expression or function of host genes & accelerate the formation of tumors by preventing cell death

Some viruses cause DNA errors to accumulate
3/4
Read 5 tweets
AJ Leonardi, MBBS, PhD Profile picture
Jan 24
In 2021 on TWIV, Vincent Raccaniello said my claims of T cell exhaustion risk were "Twitter Science™"

In 2024 I am pleased to see T cell exhaustion is Science™, Nature Immunology™, and Nature Medicine™ Science
Raccaniello is arrogant enough to the extent to reject an accurate scientific hypothesis on twitter and his TWIV podcast to the detriment of the public, without knowing enough about the subject It was completely irresponsible

Are you feigning ignorance? It was a perjorative.
Read 10 tweets
AJ Leonardi, MBBS, PhD Profile picture
Jan 23
Massachusetts General Hospital has declared a critical incident under a "capacity disaster"

Some professors at Harvard assured the crisis phase of covid was over.

I sure would be embarrassed if shown up by someone I keep proclaiming superiority over.

patch.com/massachusetts/…
Especially if I was a wunderkind Harvard professor in Cardiology.

That would mean I know at least as much immunology as a professor of immunology at a state school
Which Mark has the better takes in immunology?
Read 4 tweets
AJ Leonardi, MBBS, PhD Profile picture
Jan 15
Many people are discovering the paradox of how T cells are driving the harm- pathology- in covid-19

This was part of my publication in 2020, I gave the opinion that T cell effector function was harming organs and that it would remain significant on reinfection
Image
Can you all appreciate how much I was attacked for saying the T cells were harming and responsible for harm? It was relentless. Every Professor with Dunning Kruger went on attack-mode.
What's interesting is that when I am vindicated, it comes in titles from high-impact journals
This one is Science

For some reason the tiniest bit of what some people would call "creative imagination" sends people into a rageful frenzy. Perhaps they lack imagination themselves?
Read 5 tweets

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