BOTOX: A PRINCIPLE OF MEDICAL DIAGNOSIS & THERAPY? Several insidious medical disorders encompass similar pathophysiology seeming amenable to #Botox therapy: #Migraine, #TMJ, chronic neck pain (#cervicalgia), & Thoracic Outlet Syndrome (#TOS).
The pathophysiology found within all these disorders is the phenomenon of “crossed muscle” syndromes. Dr. Victor Janda is possibly first to describe this curious syndrome, which is easily discovered by simple physical examinations.
When the body musculoskeletal tower is asymmetric (tilted) within the ambient gravitational field, muscle pairs symmetric from side to side or which oppose in individual body part functions, become dissimilar in dynamic action; one muscle stronger & hypertrophic. The other weak.
For each of the pathologies, I have one or more extended essays in my library of threadreaders. The ideas expressed herein are my own novel findings; based on years of independent clinical medical research.
Within this current essay, I merely summarize the pathophysiologies that I have discussed at length in my several threadreaders.
Many of these findings were first made in women with Hypermobility Syndrome & who are particularly subject to the chronic injurious force that gravity imposes on musculoskeletal towers of lesser stiffness; due to widespread loose joints from inherited connective tissue variations
It is no coincidence that Fibromyalgia is highly associated with Hypermobility Syndrome & that Migraine, TMJ, chronic muscle tension headaches, chronic cervicalgia, & TOS are common in those with Fibromyalgia.
Sine qua non of Fibromyalgia (FM) is both chronic upper & lower back pain. Chronic muscle tension headaches & chronic cervicalgia (due to Superior trapezius muscle spasm) & TOS are common elements of the upper back pain component of FM.
The element of lower back pain in Fibromyalgia is sacroiliac joint (SIJ) subluxation chronic pain disorder syndrome (named by author), which is often due to chronic ligament laxity of one SIJ, but that is another story (see my threadreaders about Fibromyalgia).
Back to chronic pain syndrome subsets of Fibromyalgia & which each evolve differently & with specific chronic spastic painful hypertrophic/hyperdynamic muscles as result of chronic biomechanical gravity stress:
TEMPORAL MANDIBULAR JOINT (TMJ): My clinical research has identified unilateral Masseter muscle hyperdynamic function as etiologic for chronic wear, injury, & dysfunction of a TMJ. The medically correct name of this disorder is Temporal Mandibular Disorder, TMD.
TMD commonly evolves on side of the face most uppermost within a head that is chronically tilted; wherein weight of the higher mandible evokes dynamic Masseter function & asymmetric jaw function; as brain motor centers attempt to maintain symmetric right to left dental occlusion.
The tilted head/neck can be discovered to result from asymmetric hemi-girdles of the shoulders (each shoulder has an hemi-girdle) overlying an underlying functional scoliosis (common in those with Hypermobility Syndrome).
CHRONIC CERVICALGIA: Commonly one Superior trapezius (ST) is hypertrophic (greater girth anterior leading edge) & hyperdynamic; due to chronically tilted 10 pound head; supported mostly by stronger ST of cervical/shoulder Superior trapezium pair; supporting becomes hypertrophic.
CHRONIC CERVICALGIA is manifestation of entheses at insertion sites of Superior trapezius (ST) upon Occiput & upon Superior Scapula Spine plus painful muscle spasm impinging ST muscle mid-body motor point, a neural network in the mid-part of Superior trapezius upper aspect.
MIGRAINE HEADACHES: A pain syndrome that commonly expresses in those persons who have daily muscle tension headaches; due to chronic cervicalgia as explained above.
MIGRAINE HYPOTHESIS: Migraine represents brain tissue arteriolar wall smooth muscle spasm; resultant from autonomic neural feedback initiated within a chronically spastic Superior trapezius muscle.
THORACIC OUTLET SYNDROME: An hypertrophic & hyperdynamic Superior trapezius (“shoulder elevation” muscle) evokes hypertrophic development of opposing shoulder muscle of shoulder “draw-down”, the Pectoralis minor muscle; a true crossed muscle syndrome.
When arm abducts, Superior trapezius folds/relaxes & an hyper-dynamic (from chronic opposition to an hyper-dynamic Superior trapezius) Pectoralis minor muscle draws distal clavicle forcefully/excessively in inferior direction; as a bone radius fixed at sternoclavicular joint.
One cm of excessive inferior shift of the distal clavicle (18 cm & fixed at the sternoclavicular joint) closes the costo-clavicle dimension (Thoracic Outlet) by 30%; therein impinging the contained brachial neurovascular bundle, i.e., evoking the Thoracic Outlet Syndrome.
As a unilateral muscle of a symmetric pair (or one muscle of an opposing pair of muscles) is hyperdynamic/etiologic for a chronic pain disorder, we might hypothesize that Botox would be a natural application for crossed muscle conditions; a true Principle of Diagnosis & Therapy.
In medicine when a therapy dedicated to a theorized diagnosis then successfully evokes relief of the symptoms of the diagnosis or otherwise cures the suspected diagnosis, it can be said that the “treatment proves the diagnosis”.
Botox is a natural organic substance that in large doses is a poison to the human body, but in small doses is a miraculous treatment. Botulinum toxin is a true Principle of Treatment & Diagnosis.
In the future, physicians will be able to gather clinical data to prove the diagnostic and treatment hypotheses espoused within this essay. They will then demonstrate certain singular Principles of human functioning and Pathophysiology.

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More from @BadgleyLaurence

27 Jan
CFS MYSTERY FURTHER UNSOLVED: CFS is function of “severity” of acute infection, but not of psychologic or measurable physiologic parameters, and for a variety of viral disorders. Huh! How can this be? Impossible! Why?
Well, let’s look at what import “severity of illness” has for a host that evolves chronic fatigue. In the study, chronic musculoskeletal pain was common amongst CFS suffers, but the pain generators were not studied. Soft tissues are the most likely explanation.
Persons beset with musculoskeletal pain commonly seek a sedentary status in order to avoid arousing musculoskeletal pain transducers.
Read 13 tweets
30 Dec 20
BOTOX FOR MIGRAINES: Key to success is depositing the Botox in the best tissue: mid-body & occipital insertion site of the most spastic Superior trapezius muscle; chronic spasm of which induces chronic muscle tension headaches and reflexive Migraine.
Way to discern spastic unilateral Superior trapezius muscle: look in mirror, view your auto driver license photo, & to pinch leading edge of each Superior trapezius to determine which leading edge is painful to pressure & also thicker; from supporting a chronically tilted head.
Looking in the mirror enables the person to view which shoulder is lower. The head usually tilts toward the lower shoulder side; causing Superior trapezius muscle on the higher shoulder side to be spastic from chronically supporting a tilted head (weighs about 10#).
Read 11 tweets
28 Dec 20
The exercise program is only for persons with less severe forms of Hypermobility (those who are still physically active) & who have not advanced to Fibromyalgia/ wasting disorders (who should begin an exercise only in warm water & until they are ready for walking on land).
My theory how persons with Fibromyalgia, wasting diseases & severe fatigue should exercise is that they should start with very gentle activities whereat gravity is negated & then through gradations of activities whereby exposure to gravity is gradually increased.
The first phase of exercise for persons with Fibromyalgia & wasting diseases should be similar to what was done with polio in the 1900’s: Warm water relaxes spastic muscles & enables joint range of motion exercises with gravity relatively negated.
Read 17 tweets
28 Dec 20
CORRECTION OF FUNCTIONAL SCOLIOSIS IN CASES OF HYPERMOBILITY SYNDROME: Recently, I had a young woman with scoliosis and Gastroparesis ask me what to do about her scoliosis.
This followed upon her reading about my theory that functional scoliosis is etiologic for Gastroparesis. Functional scoliosis is my name for a mild scoliosis that seems to occur in young women with Hypermobility Syndrome.
My theory is that a curved spine affects the autonomic nerves that travel next to the spine. I believe
that Gastroparesis is a dysautonomia.
Read 17 tweets
19 Dec 20
FUNCTIONAL SCOLIOSIS was a post of 12/5/20, & wherein I discussed etiology & exam for what I call “functional scoliosis”. I showed how this disorder, common in women with Hypermobility Syndrome, potentiates evolution of Costochondritis.
Functional scoliosis also underlies etiology of many dysautonomias, such as Migraine, Thoracic Outlet Syndrome (TOS), POTS, Panic Attacks, Hyperventilation, & Gastroparesis. In this essay, I will describe my views of the pathophysiology of these disorders.
In my opinion, dysautonomias of the lower body, such as Interstitial Cystitis (IC), Irritable Bowel Syndrome (IBS), & perhaps Endometriosis, arise from neural impingements affecting autonomic nervous system tracts that regulate the tissues of these organs.
Read 98 tweets
11 Dec 20
MICROBIOME AERODYNAMICS & SEDIMENTATION RATES are studied & known. Who would have guessed that studies would uncover cloud formation & precipitation phenomenon as function of bacteria ubiquity & size.
Korean scientists quantify lift off, descent, & propagation of various bacteria “species” in the atmosphere & as high as 1,000 meters. These micro-spaceships average about 8 micrometers (if I got that right).
Atmospheric density of bacteria particles relates, in part, to their ability to nucleate with other airborne particles. Scientists can even differentiate the aerodynamic properties of these bacteria from larger (factor of 10x) pollen spores & larger fungal spores (factor of 5x).
Read 26 tweets

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