So as a patient with obesity and hyperinsulinemia begins a low carb diet there may be a reduction in LDL as the HLD of metabolic syndrome and fructose restriction comes into play...
But what happens as patients get leaner? Well there isn’t much data on long term low carb trials and certainly there isn’t much good data on the dyslipidemia of a population without metabolic syndrome
88% in the USA have one component of it... so what happens when you are free
The lipid models for people who are not eating are VASTLY different than those who are eating.
I would be remiss if I didn’t discuss the amazing work of @DaveKeto in articulating and demonstrating the energy model that explain the low carb abs intermittent fasting lipid panel...
Basically when metabolic syndrome is resolved and triglycerides are low, if someone has lost or losing weight on low carb, I would EXPECT an increase in TOTAL, LDL and HDL cholesterol especially if TRF is also being practiced.
Unfortunately, many don’t know how to interpret these numbers. As evidenced by a recent thread by @MichaelMindrum@KCKlatt where general recommendations of lowering fat, swapping for PUFA/MUFA & increasing fiber were recommended.
While these interventions won’t likely worsen a lipid panel, and is a reasonable start, it will likely NOT effect the cholesterol numbers as they expect in these specific patients, particularly if over 250 LDL like was the case brought up by them.
I don’t blame them for thinking it would, if had mild early success with such interventions but it doesn’t last.
THE MOST RELIABLE way, from my clinical experience, to decrease LDL in such a case, is ADDING starch, increasing meal frequency &/or gaining fat mass.
And since many are doing keto+IF for weight loss or maintenance, the reasonable option for many is to periodize starch to exercise and a modest amount in a second meal (separated from fat intake)
In the near future we will publish a small case series demonstrating this. But if you have followed @DaveKeto you could have expected the results. Massive decreases in LDL, amounts that are almost unfathomable.
To conclude this thread, I’d like to take this time and ask everyone to please donate to @DaveKeto charity. He will be putting your dollars to study these phenomena.
After helping thousands of patients lose weight, here’s my advice for those looking for lifelong, sustainable life changes. These are the “5 MUSTS” anyone trying to lose weight lifelong NEEDS to do.
🧵/Thread
Before you understand my “5 musts”, simply ask yourself -what are the side effects of your prior weight loss attempts- NOT your reasons, NOT what you want to happen, what went wrong, what made you stop?
The 5 Musts: #1 HUNGER
Most people quit diets because they feel low energy, tired & hungry. Your weight loss attempt will need to manage HUNGER. Are food choices making you full, or are they leaving you craving more a couple of hours later? Stick to:: 🐠🥩🍳🍗🍖🍤🫑🥑🥬🥦
Summary:
Poorly calculated
Don’t quantify hormonal effects on appetite
Labels/Tracking don’t effect intake
Worse outcomes vs. dieting
Follow along with this fully cited thread 1/n
We have known as far back as 1982 that tracking calories, food logging is inaccurate & doesn’t predict weight loss
10.1093/ajcn/35.4.727
Meta-analysis in 2008 by Harnack and French, then follow-up in 2014 from Eblel, Kiszko reviews and assesses the evidence on the effectiveness of calorie labeling at the point of purchase
"Concerns on the effectiveness of calorie labeling policies"
I have a serious problem with the term “pre-diabetes.”
The prefix “pre” is used to describe what comes before something.
In reality, “pre”-diabetes is actually AFTER or “post” 15 years of the high insulin levels & inflammation associated with the modern lifestyle.
Prediabetes is usually diagnosed by checking an a1c level, which is the percentage of hemoglobin that binds to sugar as a percentage of normal hemoglobin.
If you a1c is between 5.7 and 6.4, you are considered to have “pre-diabetes”
To achieve this level of pre-diabetes, you must sustain enough carbohydrate/glycemic excursions & weight gain where your average glucose rises sufficiently above normal levels.
The a1c describes your speed, your are past your speed limit.
How statisticians and researchers arrived at the conclusion that the BlueZones are a FRAUD. 🤔
🔑 Thread with key excerpts
1/n
“When these states transition to state-wide birth registration, the number of supercentenarians falls by 80% per year“
2/n
“The US data support the hypothesis that improved vital registration should reduce the number of supercentenarians, and be associated with changing patterns of old-age survival, by reducing age-coding error rates.”
3/n
How I approached high LDL in my patients, and how we observed a DECREASE in LDL of 480mg/dl !!!!
About my published case-series of 5 patients and clinical experience with thousands of patients …
(1/20)
As data supporting low carb diets has proliferated for weight loss, diabetes, seizures, mental health and other conditions, patients are now presenting with various issues related to the diet
2/20
For example, while it’s true that consistently a1c, triglycerides, HDL and lpa seem to improve, some patients report some adverse events.