Laurence Badgley, M.D. Profile picture
Oct 1, 2020 14 tweets 3 min read Read on X
EDS: I include EDS in the estimated 15% of women I encounter in my medical practice and who have manifest hypermobility. My view is that Mother Nature gave women genes for ligaments rendered more lax, via the hormone Relaxin, to ease the bio-mechanical assaults of childbirth.
The genes for female Hypermobility are sex linked because men are not well served, in their pursuits of war & hunting, by delicate joints of knees, spine, & pelvis.
My encounters with the common expression of Hypermobility amongst Hmong, Mexican, & Hawaiian cultures, recently evolved from a long history of agrarian-subsistence existence, led me to a theory about why hypermobility genes are so highly conserved.
In such cultures it might be the that case that family wellbeing is better fostered by a greater number of hands to generate food, even in face of additional mouths to feed.
My insight has been: men in these cultures choose wives whose mothers have a proven track record of ability to generate copious offspring. My regard is that hypermobile women generally have an easier effort birthing; especially subsequent children with abbreviated birthing times
My theories includes that abbreviated and easier births provide the offspring with less oxygen deprivation & resultant higher intelligence, which participates in enhanced survival skills. I have absolutely no data for these theories.
Indeed, it is important to identify those adolescent women with the obvious morphologies of Hypermobility so they can be guided as to types of work and sports that are non-injurious.
Hypermobile women are predisposed to permanent injury of pelvic girdle sacroiliac joints (each 17 cm square in area), largest joints in axial spine. Mundane lifting and pratfall episodes can permanently injure ligaments of these joints; with chronic low back pain consequences.
On numerous occasions, I have encountered women who developed chronic low back pain by high school & who had pursued soccer & basketball as school children. My regard is that repeated falls onto the buttocks during formative years of pelvic girdle ligament development is harmful.
Female youths should pursue swimming, golf, fencing, and other such non-contact sports that preserve ligament integrity and take advantage of the greater angles of range of motion that they possess. They can be champion swimmers & especially limber at the backstroke.
Amongst males, extreme sports of skateboarding, rugby, motocross, football etc. are popular and exceedingly threatening to major joints; especially the sacroiliac joints. Hypermobile males need to avoid these sports. Even non-hypermobiles oft permanently injured in these sports.
Most interestingly, I have certain novel opinions about the type of sports that the other gender should be wary of pursuing, but I have learned, on several occasions, that those opinions are not welcome in social media.

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More from @BadgleyLaurence

Apr 16
LOOSE JOINTS, HYPERMOBITY? Gravity is at play in these women with tissue variations. When joint are unstable the obvious compensation is “gorilla” muscles to take over lax ligament efforts. A wise Physical Therapist is key. Lots of dedicated exercise also.
LOOSE JOINTS INHERITED (-15% women) is normal. These woman’s have easier births & indigo-smart children. These women are often quite attractive and smart.
ABORIGINAL SOCIETIES
CHERISHED HYPERMOBILE
WOMEN BECAUSE THEY WERE SMART & PROLIFIC BIRTHERS. INTELLIGENCE GENES LIKELY GROUP WITH HYPERMOBILITY GENES & GENES FOR BEAUTY. MEN WANTED FECUND ATTRACTIVE WOMEN SO THEY SELECTED THEM OUT.
Read 6 tweets
Apr 14
HYPOPERFUSION? Yes, maybe sympathetic nervous system dominance + decreased pituitary vasopressin causing excess free water elimination in urine ⏩️ decreased blood circulation of hyperosmolar blood.
COVID-CAUSED decreased blood volume of blood that is too thick might explain orthodtstic hypotension, POTS. Might also explain the wormy blood clots.
COVID-CAUSED diminished total blood volume might evoke sympathetic nervous system activation to prevent hypotension and prevent syncope. Diminished blood volume would be expected to deliver less oxygen to tissues ⏩️ fatigue & exercise intolerance.
Read 5 tweets
Apr 9
TO BE GAY ON NOT, THE QUESTION? In ancient days of the mid last century, the proper medical terminology was “homosexual”. Homo is a Greek prefix for “man” such as used in our species name, homosapiens, I think. Along the way a new adjective/noun, a euphemism, was created, “gay”.
“GAYNESS” might be adverb. I don’t know, grammar not my long suit. In any case, Anthropologist of last century seemed to be of consensus that a fixed ~15% of the population was homosexual as a transcultural genetic characteristic of homosapiens. Indeed, genes direct hormones.
TO BE GAY OR NOT: THE “GREAT H & E DEBATE” (heredity vs. environment) is a dynamic that has ever lent unending entertainment and fascination to the study of the human condition & especially to the world of medical studies.
Read 7 tweets
Apr 6
MCAS IN LONG COVID: is possibly etiologic via biomechanisms known about MCAS, HYPERMOBILITY (HS) & FIBROMYALGIA (FM). Persons with HS & FM commonly suffer MCAS. Reason has been theorized that mast cells reside proximate connective tissue.
MCAS, HS, & FM: hyperflexible connective tissue evokes mast cell degranulation. Reactive substances provoke proximate neural tissues. Some experimental data for this dynamic. It might be that those with long COVID & MCAS expression might have hypermobility (about 15% women).
Read 11 tweets
Mar 12
IC CAUSE DISCOVERED: for years clinicians have been mystified by etiology of IC. Genes, microbes, toxins, & biochemistry have failed to provide insights. IC oft occurs in women who have Hypermobility Syndrome and/or IBS. These circumstances suggest that IC is a dysautonomia.
IC A DYSAUTONOMIA? parasympathetic part of autonomic system stimulates smooth tissues of bladder & bowel to contract/evacuate those organs. Over activity of this neural network is unmeasurable, as yet, in current medical sciences. Absence of evidence is not evidence of absence.
IC CLINICAL DATA: hypermobile women are potentiated for developing pelvic girdle instability from loose sacroiliac joint (SIJ) ligaments & are prone to Mast Cell Activation Syndrome (MCAS). Dr. Afrin’s book explains MCAS. I published case studies of IC remission via SIJ fusion.
Read 9 tweets
Mar 12
IRRITABLE BOWEL SYNDROME: doctors will tell you the cause is “unknown”. This is not true. IBS is commonly found in women either Hypermobility Syndrome. Reason is that these women are prone to pelvic girdle injuries and ligament laxity of one of the sacroiliac joints.
IBS & HYPERMOBILITY SYNDROME: This association well known in medical circles. Some of these women have regular daily frequent loose stools. Some have intermittent episodes of several days of constipation. Another set of these women have alternating constipation and loose stools.
IBS EXPLAINED: reason cause is “unknown” is that anatomical, tissue, and biochemical explanations are unknown and wanting. However, the dysfunction of the bowel suggests the cause is dysfunction of the autonomic nervous system, the parasympathetic and sympathetic.
Read 14 tweets

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