We have no proven early therapy for covid-19 to prevent its progression, especially in people in a higher risk category (eg age >70, male, obesity).
Fast forward.
Time will likely make a difference in our approach to how @POTUS would be treated.
By Dec/Jan monoclonal antibodies will probably be proven safe and effective. 2 Phase 2 trials have had encouraging results in outpatients. More randomized trials are ongoing.
Inhaled β-interferon also has had promising data and larger RCTs are pending.
Most people haven’t heard of this test, which is available in the US. It accurately predicts Alzheimer’s (not just if there’s a risk, but when). It is favorably affected by exercise and likely many other lifestyle factors.
Here’s (almost) everything we know about it. In Ground Truths (link in my profile d/t X-suppression)
A major @Nature paper this week found a significant decline in dementia after an outdated Shingles vaccine.
I've reviewed the study and many other relevant ones in a new Ground Truths (link in profile)
A Table from the post
The effect in the 2 natural experiments differed substantially by sex with the benefit predominant in women
The vaccine against Shingles helps protect against dementia, results of a natural experiment, adding to prior evidence
"implications are profound"
New @Nature nature.com/articles/s4158… nature.com/articles/d4158…
Of >105,000 participants with 30-year follow-up, only 9.3% achieved healthy aging (age 70, w/o any chronic diseases). Their diet was significantly associated with this outcome🧵 @NatureMedicine
These are the specific foods that were linked with healthy aging and other outcomes. Green-favorable; Red-unfavorable
Adherence to these diets (most to least in quintiles) linked to healthy aging
A paper on microplastics accumulating in the brain was just published @NatureMedicine, open-access
I review the background and major implications in a new Ground Truths edition (link in my profile)nature.com/articles/s4159…
The human brain:
—had 7-30 times more accumulation of microparticles (MPs) than the liver or kidney (organs with previously documented high propensity)
—from people with dementia had 5X accumulation of MPs compared with non-dementia
—there was a marked increase of accumulation over recent years
Three new @NEJM reports on #H5N1 today 1. An overview by @MichaelGIsonMD and @DrJeanneM
"urgent need for vigilant surveillance of emerging mutations and assessment of the threat of human-to-human transmission"
2. Report of the 13-year-old Canadian girl who developed acute respiratory failure. Sequence of her H5N1 revealed 3 mutations that may be linked to higher virulence and adaptation to human cell binding
3. Review of 46 cases of mild H5N1 illness by CDC in 2024