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Eric Topol Profile picture
@EricTopol
Oct 2, 2020 • 4 tweets • 2 min read • Read on X
We have no proven early therapy for covid-19 to prevent its progression, especially in people in a higher risk category (eg age >70, male, obesity).
Fast forward.
Time will likely make a difference in our approach to how @POTUS would be treated.
By Dec/Jan monoclonal antibodies will probably be proven safe and effective. 2 Phase 2 trials have had encouraging results in outpatients. More randomized trials are ongoing.

Inhaled β-interferon also has had promising data and larger RCTs are pending.
More color on this, mAb access, by @katie_thomas
nytimes.com/2020/10/02/hea…
Wow. Image

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More from @EricTopol

Eric Topol Profile picture
Apr 19
If you're interested in how AI grew up over the past 15 years, and where it's headed, this new book tells the story in a riveting, page-turner way. In the new Ground Truths with @scmallaby Image
In 2010, when @GoogleDeepMind was formed, well before deep learning was taking hold, @demishassabis predicted AGI by 2030 and called out the use of agents
@GoogleDeepMind @demishassabis This is pretty striking
(please excuse typo, DeepMind's) Image
Read 5 tweets
Eric Topol Profile picture
Jan 20
Physical activity and the reduction of all-cause mortality, from 2 very large prospective cohorts
1. The relationship is non-linear, suggesting a threshold effect for many types of exercise as seen below Image
2. Engaging in > 1 type of physical activity was generally correlated with better outcomes compared with 1 type (T1,2,3) Image
The @BMJMedicine was supposed to post this paper 2 hours ago but has failed to do. It is being covered by other means medicalxpress.com/news/2026-01-p…
Someday the link will be active!
dx.doi.org/10.1136/bmjmed… Image
Read 5 tweets
Eric Topol Profile picture
Jan 1
People age 70+ should not be taking aspirin at any dose for prevention. Results of randomized trials show higher risk of all-cause mortality, major bleeding events and deaths from cancer. p 153, SUPER AGERS bookImage
President Trump takes 325 mg aspirin/day. The randomized trials tested 75-81 mg/day. His doctors recommended low-dose aspirin for heart event prevention. That recommendation is ill-founded based upon best evidence in older individuals.
nejm.org/doi/full/10.10…
academic.oup.com/eurheartj/arti…Image
Aspirin dosing information
wsj.com/us-news/as-sig…
Read 4 tweets
Eric Topol Profile picture
Aug 14, 2025
As I wrote in SUPER AGERS, the immune system is the key to modulating our aging process and the opportunity to extend healthspan. Today @NatureAging 7 new articles, summarized here, that reinforce its central role
nature.com/articles/s4358…Image
Inflammaging: with aging comes untoward inflammation, a summary graphic
nature.com/articles/s4358…Image
The potential consequences of too youthful immune system in an older person —> autoimmunity
nature.com/articles/s4358…Image
Read 5 tweets
Eric Topol Profile picture
Aug 7, 2025
The new special issue @ScienceMagazine features Immunity with 4 outstanding review papers, 5★
Our immune system over the lifespan, sex differences, influence on physiology, and host antiviral defenses science.org/toc/science/cu…Image
Our immune system as we age: the path to immunosenesence and inflammaging
science.org/doi/10.1126/sc…Image
Sex differences science.org/doi/10.1126/sc…Image
Read 5 tweets
Eric Topol Profile picture
Jun 8, 2025
We've learned a lot more about the principal drivers of age-related diseases in the past few weeks. And that leads to a unified model to pull it all together. (open-access) Image
I review 4 new reports, summarized here:
1. The proteins from senescent cells predict age-related clinical outcomes
2. A new epigenetic age clock connects the dots between aging, the immune system, inflammation and lifestyle factors
3. People with a fast pace of aging had an increased risk of cognitive impairment, age-related diseases, disability, and mortality
4. The Importance of “Immune Resilience” for Healthspan
And present a unified I/I model for what we now know Image
Read 4 tweets

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