Eric Topol Profile picture
physician-scientist, author, editor https://t.co/vwstu2BYrC Ground Truths: https://t.co/YhatcCa3jA
Dame Chris🌟🇺🇦😷 #RejoinEU #FBPE #GTTO🔶️ Profile picture eDo Profile picture BlackeyedSusan28 Is Fully Vaccinated Profile picture Phillip D. Long Profile picture Sadie Profile picture 464 subscribed
Aug 25 4 tweets 2 min read
Big news #ESC2023 and @NEJM
In a placebo-controlled randomized trial of people with obesity + heart failure (with preserved ejection fraction). semaglutide (Wegovy) markedly improved symptoms, exercise time, reduced inflammatory markers (and weight loss)
nejm.org/doi/full/10.10…

Image
Image
This also tells us something about the underlying mechanism of heart failure with preserved EF—metabolic dysfunction and attendant systemic inflammation—not previously acknowledged or confirmed
Aug 21 5 tweets 2 min read
Two new papers @NatureMedicine and @JAMAInternalMed shed light on #LongCovid at 2-years. But there's no shortage of known unknowns.
Reviewed in a new Ground Truths (link in my profile, because that would be it X-suppressed) Image Links to the new reports
@NatureMedicine by @zalaly and colleagues
@JAMAInternalMed nature.com/articles/s4159…
jamanetwork.com/journals/jamai…
Image
Aug 4 5 tweets 2 min read
The EG.5 variant continues to show a growth advantage in the latest US genomics surveillance, from 11->17% in past 2 weeks
FL.1.5.1 also on the rise. The XBBs are on the wane. https://t.co/50Eq338zXLcovid.cdc.gov/covid-data-tra…
Image EG.5.1 rise seen in many other places, nicely summarized in @kallmemeg 's thread about the new @UKHSA report
https://t.co/Ba3GZmwVWF
Image
May 10 4 tweets 4 min read
I wrote about 2 groundbreaking pancreatic cancer studies this week: #AI identifying high-risk individuals and a vaccine clinical trial published @Nature today
erictopol.substack.com/p/a-one-two-pu… On the new @Nature individualized vaccine clinical trial vs pancreatic cancer
nature.com/articles/d4158… @NatureNV @NeehaZaidi Image
May 3 4 tweets 4 min read
A fascinating report @Nature today on the bidirectional interaction of brain/mind and cancer
nature.com/articles/d4158…
nature.com/articles/s4158… Image "These two ghosts in the machine, the mind
and the tumour, whispering to each other
in the dark recesses of the brain, engage in a
conversation that could be well worth eavesdropping on."
Apr 21 4 tweets 2 min read
The US transition to the XBB.1.16 variant continues, the variant driving a new wave in India (see🧵by @akshathk5), but unlikely to have such impact here
covid.cdc.gov/covid-data-tra… Image Spike mutation maps for XBB.1.5 and XBB.1.16 show the 2 added (E180V, K478R)
by @firefoxx66
Image
Apr 17 4 tweets 4 min read
A group of infectious disease specialists argue that universal face masks in health care settings is no longer necessary
acpjournals.org/doi/10.7326/M2…
@AnnalsofIM
by @ericashenoy @h_babcock @KarenBrustMD @CalderwoodMD @ShiraDoronMD @wbranchelliman ImageImage Here is the counterargument from @ct_degroot
Image
Apr 10 4 tweets 2 min read
This is big, folks. The @WhiteHouse is supporting next generation—nasal and variant-proof Covid vaccines —and therapies with a $5 billion program by @ddiamond
Thanks to the relentless efforts of @AshishKJha46 and @WHCOVIDResponse👍washingtonpost.com/health/2023/04… The background and rationale for this important initiative
https://t.co/CrEaqcJkXeerictopol.substack.com/p/project-next…
Apr 6 4 tweets 3 min read
Important new report on #LongCovid and the brain demonstrating persistence of the virus spike protein, throughout the body and particularly the skull-meninges axis, both in humans and the mouse model
biorxiv.org/cgi/content/sh… by @erturklab @zhouyi_rong @HongchengM
@Sakethkapoor Image
Mar 3 6 tweets 4 min read
Heart attacks, strokes and other major adverse outcomes doubled in people post-Covid at 1 year compared with matched uninfected controls #LongCovid, replicating previous reports
jamanetwork.com/journals/jama-… @JAMAHealthForum Image Table of the various 1-year adverse outcomes for both full cohort and those hospitalized along with all-cause mortality graph Image
Feb 16 5 tweets 3 min read
New @TheLancet
Prior Covid provided high protection vs severe disease, including Omicron BA.1 ( ~90% at 10 months post-infection), as determined by systematic review of 65 studies
Protection vs reinfection was high (~78% at 10 months) until Omicron,⬇️to ~44% w/ more rapid⬇️ Link thelancet.com/journals/lance…
Graph shows comparison vs vaccination for different outcomes over time
Conclusion👇pulls a lot of data all together
Work by @IHME_UW team
Feb 15 4 tweets 3 min read
The RSV virus was discovered in 1956 and sequenced in 1982. Only now do we have effective vaccines. Today @NEJM results for age 65+ randomized trial
nejm.org/doi/full/10.10… Another RSV vaccine much larger randomized trial (also of 1 dose) with very high efficacy in people age 60+
nejm.org/doi/full/10.10…
Feb 10 4 tweets 2 min read
The XBB.1.5 variant now accounts for ~75% of new cases in the United States, with no other variant showing gains (including CH.1.1)
covid.cdc.gov/covid-data-tra… All regions are XBB.1.5 dominant except the Northwest
Feb 8 7 tweets 3 min read
Interferon λ, a new way to cut hospitalizations by 50% after Covid, in a randomized, placebo-controlled trial >2,000 patients age 50+ or high risk
@dr_gilmarreis and colleagues
nejm.org/doi/full/10.10… Consistent impact across variants, ~50% Omicron
Jan 31 4 tweets 2 min read
My interview with @AshishKJha46, leader of the @WHCOVIDResponse, about the pandemic
We covered many important issues🧵
medscape.com/viewarticle/98…
1. Underuse of Paxlovid in older patients: not backed up by low incidence of rebound and ease of sidestepping potential drug interactions 2. Pharmacists unwilling to prescribe Paxlovid, even though empowered (these are results from new @Medscape survey)
3. Dr. Jha is a champion for developing nasal and universal coronavirus vaccines and explains why it hasn't happened (yet)
Jan 31 5 tweets 2 min read
The United States, the perennial outlier when it comes to healthcare spending and outcomes
New data through 2021 vs peer countries by @commonwealthfnd
commonwealthfund.org/publications/i…
Worst @OECD life expectancy With highest spending
Jan 25 6 tweets 4 min read
A couple of weeks ago I reviewed the BA.5 bivalent booster data and concluded it has worked better than expected
erictopol.substack.com/p/the-bivalent…
Today there are 3 new reports that strongly reinforce that
1. Comparing bivalent vs original for protection vs hospitalizations & deaths 2. Superior neutralizing antibodies vs the new variants with marked immune evasion: XBB.1, BQ.1.1, BA.2.75 compared with the original booster (adds to 12 lab studies)
Jan 25 4 tweets 3 min read
Just published @Nature
Impressive. A wearable patch that acquires continuous, real-time ultrasound images of the heart at rest, on the go, and during exercise (echocardiograms) with automated processing
nature.com/articles/s4158… sample video
Jan 23 4 tweets 2 min read
The benefit of bivalent boosters for enhanced, ~80% protection from hospitalizations and deaths (vs vaccine plus prior prior booster or unvaccinated) has now been shown in 6 countries (Israel, US, Denmark, Norway, Finland, Sweden) Link to above Figure and dataset
medrxiv.org/content/10.110…
Full discussion
erictopol.substack.com/p/the-bivalent…
Jan 16 4 tweets 2 min read
The #AI takes the medicine qualifying exam.
Three to take note:
1. China, 2017, Xiaoyi passed the licensing exam with a score of 456 (passing 360-600) based on memorization and information recall, with poor performance on patient cases 2. UK, 2022, the machine took the radiology qualifying exam, compared with 26 radiologists who recently passed. Overall accuracy 79.5% compared with 84.8% for the radiologists.
Jan 11 4 tweets 2 min read
A new retrospective nationwide EHR assessment of #LongCovid in ~230,000 people w/ mild Covid and matched controls for age, sex, vaccination status, variant
Some downplaying of persistent symptoms at 1 year:
1. Median age of cohort = 25 years. People age 41-60 had worse outcomes 2. Major symptoms of difficulty breathing, cognitive impairment and weakness were present at 1 year. Also loss of smell, taste, dizziness and cough