Eric Topol Profile picture
physician-scientist, author, editor https://t.co/vwstu2BYrC
Antone Johnson 🇺🇸🇺🇦 Profile picture Dame Chris🌟🇺🇦😷 #RejoinEU #FBPE #GTTO🔶️ Profile picture eDo Profile picture BlackeyedSusan28 Is Fully Vaccinated Profile picture Phillip D. Long Profile picture 377 added to My Authors
Sep 23 7 tweets 4 min read
New US #SARSCoV2 genomic surveillance data
The proportion of BA.5 cases is declining, as new variants are out-competing, some of which have already been shown to have more immune escape such as BA.2.75.2 and BQ.1.1
covid.cdc.gov/covid-data-tra… Image Here @SolidEvidence has mapped out their evolutionary path with a convergence of several mutations Image
Sep 21 4 tweets 4 min read
There are too many new #SARSCoV2 variants on the radar screen that show growth advantage vs BA.5, and 2 with extreme immune evasiveness to date. One is a BA.5 descendant, BQ.1.1; the other is derived from BA.2, BA.2.75.2. They share a RBD mutation, R346T
(Maps from @PeacockFlu) Here's the full, frequently updated list cov-spectrum.org/collections/24 @GenSpectrum
Thanks to so many keeping a close eye on these, including @siamosolocani @CorneliusRoemer @PeacockFlu @SolidEvidence @LongDesertTrain @richardneher and others 🙏
Sep 20 4 tweets 3 min read
Why the pandemic isn't over yet and how we can get there faster
latimes.com/opinion/story/…
my @latimes oped Image In agreement, by @washingtonpost editorial board
washingtonpost.com/opinions/2022/…
@PostOpinions Image
Sep 19 4 tweets 2 min read
Wish this was true. What's over is @POTUS's and our government's will to get ahead of it, with magical thinking on the new bivalent boosters. Ignores #LongCovid, inevitability of new variants, and our current incapability for blocking infections and transmission And what about the 400-500 Americans dying each day since April
Sep 18 13 tweets 8 min read
Lifting the booster fog
The evidence supporting boosters is incontrovertible. Summary of data for 4th vs 3rd shots for survival benefit, age 50+
The unequivocal benefit is for enhanced protection vs severe Covid Image 2. The most recent @CDCgov data, compared with unvaccinated, age 50+
4 shots: 94% reduction of death
3 shots: 83.5% reduction of death Image
Sep 16 4 tweets 4 min read
Now beyond an untreatable cancer case report (below), a potential breakthrough for severe autoimmune disease: using engineered T cells in 5 young patients with refractory lupus
nature.com/articles/s4159…
@NatureMedicine
theguardian.com/science/2022/s… @guardianscience ImageImage Why is this a big deal?
Because we're seeing the ability to engineer our T cells to both rev up our immune system to fight cancers and knock down our immune system to stop autoimmune attacks....in both cases for untreatable, refractory conditions
Sep 8 4 tweets 3 min read
Excellent, succinct review of myalgic encephalomyelitis (ME/CFS) and its overlapping features with #LongCovid
@ScienceMagazine
science.org/doi/10.1126/sc… Image Full text here ImageImage
Sep 6 4 tweets 3 min read
The @BharatBiotech nasal vaccine got EUA regulatory approval in India today following its ~4,000 participant randomized trial timesofindia.indiatimes.com/india/bharat-b…
Efficacy data not yet presented This follows yesterday's first inhaled vaccine approval, in China, representing a 2nd major step in the quest for achieving mucosal immunity vs Covid
Sep 5 4 tweets 3 min read
🆕 @NatureMedicine
Heart manifestations of #LongCovid
A prospective MRI study of 346 people with mild Covid, and controls, demonstrated myocardial inflammation at 3 months, worse w/ symptoms, and edema at ~1 year
by @v_puntmann and colleagues @GoetheCVI
nature.com/articles/s4159… Image "The imaging findings suggest that inflammatory cardiac involvement after COVID may be a pathophysiological commonality shared among all individuals, regardless of the expression of cardiac symptoms" Image
Sep 3 6 tweets 3 min read
The BA.5 variant wave is in descent in the US and throughout the world. Without a threatening new variant that exhibits ability to strongly compete now, we should have several weeks of a respite
World cases/ deaths
Japan, one of the last to get hit, still on the rise for deaths The US metrics
Except for deaths that remain at a ~500 deaths/day plateau, all are pointing in the right direction
Cases are notoriously under-reported, but we are at the lowest level in 4 months, (that number of confirmed cases, 78K, is still very high) /2
Aug 31 4 tweets 3 min read
The historic drop in US life expectancy
Biggest two-year decline —2.7 years in total — in almost 100 years
Now 76.1, the lowest in 25 years
Levels at 1944 for AIAN
Pandemic, accidents and overdoses were 1° drivers
nytimes.com/2022/08/31/hea…
cdc.gov/nchs/data/vsrr… This precipitous drop and current level is substantially worse than 21 peer countries
medrxiv.org/content/10.110…
Aug 29 4 tweets 2 min read
Hey United States, not a good past 12 months in the prevention of Covid fatalities
@OurWorldInData Who's dying in the US?
All ages, last 3 months, weekly, per 100,000 people
ourworldindata.org/search?q=death…
Aug 23 4 tweets 2 min read
Good explainer of imprinting, aka original antigenic sin, and how it may influence response to the BA.5 booster vaccine response
washingtonpost.com/health/2022/08… by @Carolynyjohnson Some views lacking optimism. Key point re: reduction of infections/ transmission and why a nasal vaccine booster, if efficacious, would be a better bet.
Also supports getting human nAb data before rolling out (which may not happen)
Aug 17 6 tweets 5 min read
In 1.28 million people, up to 2 years after Covid, w/ matched controls: "The persisting increased risk of post-COVID cognitive deficit, dementia, psychotic disorders, and epilepsy or seizures" and "similar during the delta and omicron waves" #LongCovid
thelancet.com/journals/lanps… US data, lack of differences between variants (Alpha, Delta, Omicron)
Aug 15 5 tweets 2 min read
I wrote about the new @CDCgov Covid guidelines intended to shift the focus to protect the most vulnerable, representing a blatant failure
theguardian.com/commentisfree/… How it does not protect the vulnerable
X 5-day isolation policy
X Only 6% of immunocompromised Americans have received Evusheld prevention
X The "Community" level metric is contrived and deceptive
X "Fully vaccinated" should = 3 shots; 4 shots for age 50+
X Ignores #LongCovid
Aug 14 11 tweets 5 min read
What variant will take over for BA.5 in the United States and why does it matter?
It's currently between a BA.4/5 vs BA.2 subvariant While BA.2.75 is becoming dominant in India, out-competing BA.5, we're now seeing signs it can also compete with BA.4.6 in Australia, as posted by @Mike_Honey_ /2
Aug 11 7 tweets 4 min read
The @CDCgov doubles down on its flawed, not evidence based Covid recommendations with a new guidance document
1. Leaves fully vaccinated = 2 shots, stay "up to date"
2. Leaves isolation at 5 days w/o rapid tests
3. Pushes "community levels" when real info is "transmission levels" cdc.gov/mmwr/volumes/7… is the link
Aug 9 4 tweets 4 min read
Why are people age 50+ at higher risk of severe Covid?
A new @PNASNews study indicates their significant narrowing of T cell diversity in response to infections may be part of the explanation
pnas.org/doi/10.1073/pn… ImageImage And what happens if you deplete CD8+ (cytotoxic) T cells with a monoclonal antibody after vaccination + #SARSCoV2 infection?
science.org/doi/epdf/10.11… @SciImmunology (macaque model) ImageImage
Aug 7 6 tweets 3 min read
Had the chance the discuss the current status of #LongCovid with @holmescnn last evening We reviewed the new @TheLancet study, best one so far to establish true incidence (pre-Omicron, with caveats below)
Jul 27 4 tweets 2 min read
There are 5 studies that show reduction of mortality for a 2nd booster (vs 1st booster), in people ranging from age 50+ to 80+, as I've tried to summarize here. All during Omicron and subvariants. Yet less than 10% of people age 50-64, and 24% age 65+ have had a 2nd booster
covid.cdc.gov/covid-data-tra…
Jul 21 6 tweets 4 min read
In today's @SciImmunology, @VirusesImmunity and I call for Operation Nasal Vaccine, the urgent need for a lightened speed initiative, to help block Covid infections and transmission
science.org/doi/10.1126/sc… It accompanies an elegant study in people & mice. There was little to no lower respiratory mucosal immunity (BAL nAb) vs Omicron after mRNA vaccines, but this was markedly ameliorated w/adding a nasal vaccine in mice
science.org/doi/10.1126/sc… by @ImmunologyTang @Jie_Immunology