Eric Topol Profile picture
physician-scientist, author, editor. Ground Truths: https://t.co/YhatcBT0hA
Dame Chris🌟🇺🇦😷 #RejoinEU #FBPE #GTTO🔶️ Profile picture eDo Profile picture BlackeyedSusan28 Is Fully Vaccinated Profile picture Phillip D. Long Profile picture Sadie Profile picture 489 subscribed
Jan 22 4 tweets 2 min read
Breaking down the risks and benefit for lecanemab, the amyloid beta-directed antibody vs Alzheimer's drug approved @US_FDA last year. It doesn't look good.

@AnnalsofIM acpjournals.org/doi/10.7326/M2…
Image A new systematic review of these antibodies looks even worse @AnnFamMed doi.org/10.1370/afm.30…



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Jan 4 4 tweets 2 min read
My oped on the JN.1 variant and the 2nd biggest US wave of infections (after Omicron) since the pandemic began
@latimes @latimesopinion #LongCovid latimes.com/opinion/story/…
Image Recent @CDCgov #SARSCoV2 wastewater data for current wave (vs Omicron Jan 2022 and subsequent waves), graph by @luckytran Image
Nov 23, 2023 6 tweets 3 min read
3 New #LongCovid reports
1. Vaccination protection—1 dose 21%, 2 doses 59%, 3 doses 73% among ~590,000 people in Sweden (strong association)
bmj.com/content/383/bm…
Image 2. 3-year prospective follow up of a cohort of ~1350 participants, hospitalized in China
—Lung function restored back to baseline in most
—Higher risk of reinfection that people w/o Long Covid
—Half w/ persistent symptoms
thelancet.com/journals/lanre…
Aug 25, 2023 4 tweets 2 min read
Big news #ESC2023 and @NEJM
In a placebo-controlled randomized trial of people with obesity + heart failure (with preserved ejection fraction). semaglutide (Wegovy) markedly improved symptoms, exercise time, reduced inflammatory markers (and weight loss)
nejm.org/doi/full/10.10…

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This also tells us something about the underlying mechanism of heart failure with preserved EF—metabolic dysfunction and attendant systemic inflammation—not previously acknowledged or confirmed
Aug 21, 2023 5 tweets 2 min read
Two new papers @NatureMedicine and @JAMAInternalMed shed light on #LongCovid at 2-years. But there's no shortage of known unknowns.
Reviewed in a new Ground Truths (link in my profile, because that would be it X-suppressed) Image Links to the new reports
@NatureMedicine by @zalaly and colleagues
@JAMAInternalMed nature.com/articles/s4159…
jamanetwork.com/journals/jamai…
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Aug 4, 2023 5 tweets 2 min read
The EG.5 variant continues to show a growth advantage in the latest US genomics surveillance, from 11->17% in past 2 weeks
FL.1.5.1 also on the rise. The XBBs are on the wane. https://t.co/50Eq338zXLcovid.cdc.gov/covid-data-tra…
Image EG.5.1 rise seen in many other places, nicely summarized in @kallmemeg 's thread about the new @UKHSA report
https://t.co/Ba3GZmwVWF
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May 10, 2023 4 tweets 4 min read
I wrote about 2 groundbreaking pancreatic cancer studies this week: #AI identifying high-risk individuals and a vaccine clinical trial published @Nature today
erictopol.substack.com/p/a-one-two-pu… On the new @Nature individualized vaccine clinical trial vs pancreatic cancer
nature.com/articles/d4158… @NatureNV @NeehaZaidi Image
May 3, 2023 4 tweets 4 min read
A fascinating report @Nature today on the bidirectional interaction of brain/mind and cancer
nature.com/articles/d4158…
nature.com/articles/s4158… Image "These two ghosts in the machine, the mind
and the tumour, whispering to each other
in the dark recesses of the brain, engage in a
conversation that could be well worth eavesdropping on."
Apr 21, 2023 4 tweets 2 min read
The US transition to the XBB.1.16 variant continues, the variant driving a new wave in India (see🧵by @akshathk5), but unlikely to have such impact here
covid.cdc.gov/covid-data-tra… Image Spike mutation maps for XBB.1.5 and XBB.1.16 show the 2 added (E180V, K478R)
by @firefoxx66
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Apr 17, 2023 4 tweets 4 min read
A group of infectious disease specialists argue that universal face masks in health care settings is no longer necessary
acpjournals.org/doi/10.7326/M2…
@AnnalsofIM
by @ericashenoy @h_babcock @KarenBrustMD @CalderwoodMD @ShiraDoronMD @wbranchelliman ImageImage Here is the counterargument from @ct_degroot
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Apr 10, 2023 4 tweets 2 min read
This is big, folks. The @WhiteHouse is supporting next generation—nasal and variant-proof Covid vaccines —and therapies with a $5 billion program by @ddiamond
Thanks to the relentless efforts of @AshishKJha46 and @WHCOVIDResponse👍washingtonpost.com/health/2023/04… The background and rationale for this important initiative
https://t.co/CrEaqcJkXeerictopol.substack.com/p/project-next…
Apr 6, 2023 4 tweets 3 min read
Important new report on #LongCovid and the brain demonstrating persistence of the virus spike protein, throughout the body and particularly the skull-meninges axis, both in humans and the mouse model
biorxiv.org/cgi/content/sh… by @erturklab @zhouyi_rong @HongchengM
@Sakethkapoor Image
Mar 3, 2023 6 tweets 4 min read
Heart attacks, strokes and other major adverse outcomes doubled in people post-Covid at 1 year compared with matched uninfected controls #LongCovid, replicating previous reports
jamanetwork.com/journals/jama-… @JAMAHealthForum Image Table of the various 1-year adverse outcomes for both full cohort and those hospitalized along with all-cause mortality graph Image
Feb 16, 2023 5 tweets 3 min read
New @TheLancet
Prior Covid provided high protection vs severe disease, including Omicron BA.1 ( ~90% at 10 months post-infection), as determined by systematic review of 65 studies
Protection vs reinfection was high (~78% at 10 months) until Omicron,⬇️to ~44% w/ more rapid⬇️ Link thelancet.com/journals/lance…
Graph shows comparison vs vaccination for different outcomes over time
Conclusion👇pulls a lot of data all together
Work by @IHME_UW team
Feb 15, 2023 4 tweets 3 min read
The RSV virus was discovered in 1956 and sequenced in 1982. Only now do we have effective vaccines. Today @NEJM results for age 65+ randomized trial
nejm.org/doi/full/10.10… Another RSV vaccine much larger randomized trial (also of 1 dose) with very high efficacy in people age 60+
nejm.org/doi/full/10.10…
Feb 10, 2023 4 tweets 2 min read
The XBB.1.5 variant now accounts for ~75% of new cases in the United States, with no other variant showing gains (including CH.1.1)
covid.cdc.gov/covid-data-tra… All regions are XBB.1.5 dominant except the Northwest
Feb 8, 2023 7 tweets 3 min read
Interferon λ, a new way to cut hospitalizations by 50% after Covid, in a randomized, placebo-controlled trial >2,000 patients age 50+ or high risk
@dr_gilmarreis and colleagues
nejm.org/doi/full/10.10… Consistent impact across variants, ~50% Omicron
Jan 31, 2023 4 tweets 2 min read
My interview with @AshishKJha46, leader of the @WHCOVIDResponse, about the pandemic
We covered many important issues🧵
medscape.com/viewarticle/98…
1. Underuse of Paxlovid in older patients: not backed up by low incidence of rebound and ease of sidestepping potential drug interactions 2. Pharmacists unwilling to prescribe Paxlovid, even though empowered (these are results from new @Medscape survey)
3. Dr. Jha is a champion for developing nasal and universal coronavirus vaccines and explains why it hasn't happened (yet)
Jan 31, 2023 5 tweets 2 min read
The United States, the perennial outlier when it comes to healthcare spending and outcomes
New data through 2021 vs peer countries by @commonwealthfnd
commonwealthfund.org/publications/i…
Worst @OECD life expectancy With highest spending
Jan 25, 2023 6 tweets 4 min read
A couple of weeks ago I reviewed the BA.5 bivalent booster data and concluded it has worked better than expected
erictopol.substack.com/p/the-bivalent…
Today there are 3 new reports that strongly reinforce that
1. Comparing bivalent vs original for protection vs hospitalizations & deaths 2. Superior neutralizing antibodies vs the new variants with marked immune evasion: XBB.1, BQ.1.1, BA.2.75 compared with the original booster (adds to 12 lab studies)
Jan 25, 2023 4 tweets 3 min read
Just published @Nature
Impressive. A wearable patch that acquires continuous, real-time ultrasound images of the heart at rest, on the go, and during exercise (echocardiograms) with automated processing
nature.com/articles/s4158… sample video