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Lior Pachter Profile picture
@lpachter
Oct 3, 2020 • 6 tweets • 3 min read • Read on X
Trump was administered REGN-COV2 by compassionate use request. "...this type of compassionate use..is..intended for patients with serious or life-threatening conditions who do not have any viable or available treatment options..." investor.regeneron.com/static-files/f…
The only published evidence on effectiveness of REGN-COV2 so far is a preprint that showed "REGN-COV2 reduced the amount of virus and associated damage in the lungs of non-human primates." It was tested in rhsesus macaques and hamsters. biorxiv.org/content/10.110…
A recent descriptive analysis of the ongoing trial shows "..a 0.51 log10 copies/mL greater reduction (p=0.0049) in patients treated with high dose, & a 0.23 log10 copies/mL greater reduction (p= 0.20) in patients treated with low dose, compared to placebo" investor.regeneron.com/news-releases/…
"Among the first 275 patients, approximately 56% were Hispanic, 13% were African American and 64% had one or more underlying risk factors for severe COVID-19, including obesity (more than 40%). On average, patients were 44 years of age."
Here's what @EricTopol has to say about REGN-COV2: "There’s nothing bad about these results, you just can’t say much about how transformative this is going to be." He warned that the data so far should not be enough for the @US_FDA to grant an EUA. statnews.com/2020/09/29/reg…
Meanwhile... $REGN

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More from @lpachter

Lior Pachter Profile picture
Sep 10
So this plagiarism thing has happened to our lab.. again. This time it's plagiarism of our poseidon syringe pump paper @booeshaghi et al., 2019 in @SciReports:
Text has been plagiarized, as well as figures copied directly here: 1/🧵nature.com/articles/s4159…
ijirset.com/upload/2024/ma…
Here is figure 1 from our paper (LHS) and figure 1 in the plagiarized paper (RHS) published in the "International Journal of Innovative Research" 2/ ijirset.com/upload/2024/ma…

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The text seems to have been rewritten with an LLM. Our introduction (LHS) vs. the plagiarized version (RHS): 3/
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Read 11 tweets
Lior Pachter Profile picture
Aug 16
I've checked this paper out, as instructed. I was also interested in the main result for personal reasons: I'm 51 years old. Is it true that I've just gone through a major change? And that another one awaits me in just a few years?

Some comments on the paper in this thread 1/🧵
The main result about major changes in the mid 40s and 60s is shown in this plot (Fig. 4a). First, I redrew it with axes that start at 0, so the scale of change here was clearer. Not as impressive, but maybe it's a thing? 2/
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The authors say that this finding is even corroborated in another study (ref 14). But that's not true. I looked it up, and it shows something totally different (see RHS Fig 3c from ref 14). No change in mid 40s, but a change in the mid 30s, and the real change in the 80s 😕 3/
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Read 17 tweets
Lior Pachter Profile picture
Aug 10
I recently posted on @bound_to_love's work quantifying long-read RNA-seq. In response, a scientist acting in bad faith (Rob Patro @nomad421) trashed our work. This kind of mold in science's bathroom is extremely damaging so here's a bit of bleach. 1/🧵
At issue are benchmarking results we performed comparing our tool, lr-kallisto, to other programs including Patro's Oarfish. Shortly after we posted our preprint Patro started subtweeting our work, claiming we'd run an "appallingly wrong benchmark" and that we're "bullies". 2/
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This was followed, within days, by Patro posting a hastily written preprint disguised as research work on benchmarking, but really just misusing @biorxivpreprint to broadcast the lie that our work "... may be repeatable, but it appears neither replicable nor reproducible." 3/ Image
Read 25 tweets
Lior Pachter Profile picture
Aug 1
This recently published figure by @Sarah_E_Ancheta et al. is very disturbing and should lead to some deep introspection in the single-cell genomics community (I doubt it will).

It demonstrates complete disagreement among 5 widely used "RNA velocity" methods 1/ Image
This is of course no surprise. In "RNA velocity unraveled" by @GorinGennady et al. in @PLOSCompBiol we wrote 55 page paper explaining the many ways in which RNA velocity makes no sense. 2/ journals.plos.org/ploscompbiol/a…
We're not the only ones to understand how flawed RNA velocity is. The paper from the groups of @KasperDHansen and @loyalgoff is titled "pumping the brakes on RNA velocity". The whole notion of putting arrows on UMAPs is ridiculous. 3/genomebiology.biomedcentral.com/articles/10.11…
Read 6 tweets
Lior Pachter Profile picture
Jul 29
I was recently schooled on some Gen Z and Gen Alpha brainrot. Here's a yap about it:

1/🧵
Delulu:

"I just submitted my R01. I'm sure this one is going to finally get funded!"

You're delulu.

2/
Cap:

"Reviewer #3 accepted our paper without revisions no cap!!"

You're capping be for real! 3/
Read 13 tweets
Lior Pachter Profile picture
Jul 25
Challenge accepted. Here are a few comments on the paper after starting to wade through its massive content. The paper in question is 1/🧵 nature.com/articles/s4158…
First, the claim that "lower OPC fraction across regions and, in particular, in non-neocortex regions was significantly associated with impaired cognition (Supplementary Fig. 37d)" is not true. Supp. Fig. 37d is below. I've boxed in red the panel the claim is based on. 2/ Image
The R^2 value, i.e. proportion of variance explained is 0.0256. The "significance" claim is based on the reported p-value of 0.0071 which is less than 0.05. However significance vanishes once one corrects for the number of tests performed. 3/
Read 22 tweets

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