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Paul Saladino, MD

@paulsaladinomd

Dec 5

I cleaned 48 years of toxins from my blood…

I analyzed what came out and what I found blew my mind (results at the end of this post)…

In this bag is the “eluate” from a “blood cleaning” procedure called Inuspheresis.

At the bottom, you can see all of the brown material, which is 48 years of accumulated toxins.

Pesticides, plastic residues, forever chemicals, heavy metals, microplastics, etc.

These things are VERY difficult to remove from our bodies without some sort of serious detoxification.

I have not always been as intentional about my diet and lifestyle, and I wondered about what sort of toxins were in my body.

I generally prefer to eat clean and spend time in nature.

But this “biohack” was interesting to me. Let me explain further.

Read 11 tweets

Paul Saladino, MD

@paulsaladinomd

Sep 15

Taurine is the next creatine.

Hear me out...

RCTs in humans show clear benefits from taurine (1-6g per day) in both disease states and for exercise performance.

Taurine is powerful stuff. 🧵

Blood pressure reduction (PMID: 26781281), both SBP (systolic) and DBP (diastolic)

Improved vascular function in Type 2 DM (40546935)

Improved markers of metabolic syndrome including SBP/DBP, decreased triglycerides, decreased fasting glucose (38755142)

Decreased HgbA1c, fasting glucose, HOMA-IR, fasting insulin in type II DM and obesity cohorts (35769396, 39796489)

Read 16 tweets

Paul Saladino, MD

@paulsaladinomd

Sep 15

Biggest nutrient deficiency in the US?

Potassium? Choline? Vitamin D?

Nope, it’s infrared light (760-1000nm). 🧵

Believe it or not, the mitochondria in every cell in your body make the MAJORITY of your melatonin. (>95%) in response to infrared light (PMID 36671781, 29164625)

And almost NONE of us are getting enough of it.

We spend >97% of our lives indoors, where there is very little IR light.

If you live 86 years, you will spend 83 of them indoors.

Most of us spend less than 30 minutes per day truly outside. No bueno.

Read 8 tweets

Paul Saladino, MD

@paulsaladinomd

Apr 2

I am not a fan of methylene blue. The data clearly shows that unless you have a block in your electron transport chain, it LOWERS ATP production in your mitochondria.

I think most people are conflating MAO-A inhibition and serotonergic effects with mitochondrial benefit.

Yes, metabolic dysfunction is common but methylene blue is not the way to address this.

The easy root cause solution is to cut out seed oils and processed sugars rather than turning your tongue (and brain) blue.

PMID: 21454572, 25277417, 35777722

Read 4 tweets

Paul Saladino, MD

@paulsaladinomd

Mar 9

Sugar is bad for you, but not for the reason you think.

Sugar is NOT bad for you because it raises your blood sugar.

Sugar is bad for you because it causes dysbiosis in your gut => increases endotoxin =>inflammation/metabolic dysfunction.

A thread... 🧵

From the outset, it's important to point out that "naked sugar" (think table sugar= sucrose and high fructose corn syrup) has different effects in the body than sugar consumed as a part of fruits/fruit juice/honey etc.. we'll get to this eventually...

Most believe that "naked sugar" is bad for you because if raises your blood glucose, but there is a dearth of evidence to actually suggest that raising your blood sugar is harmful for humans at all independent of pre-existing diabetes (PMID: 30249012).

Read 25 tweets

Paul Saladino, MD

@paulsaladinomd

Jan 1

Fasting insulin is a SINGLE, CHEAP, EASY BLOOD TEST that could change the health landscape in the United States over night.

If every doctor ordered a fasting insulin ($30) on their patients -and knew how to interpret it**- we would immediately understand how great the burden of metabolic dysfunction in our country is and we could begin targeting it effectively.

The problem here is doctors are NOT taught that:

a) metabolic dysfunction (aka insulin resistance) lies at the root of the MAJORITY of chronic illness in our country...

b) metabolic dysfunction is EASILY diagnosable...

c) metabolic dysfunction is EASILY reversible.

Read 16 tweets

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