I find it curious that the President is taking *TWO* experimental drugs in response to his COVID-19 diagnosis.

That feels… odd to me.
The Regeneron monoclonal antibody cocktail is truly experimental, and has only been used in a few hundreds of patients.

Using that, in combination with an anti-viral drug, Remdesivir that has *some* indications for efficacy.
And studies involving BOTH of those drugs at the same time, are effectively non-existent to my knowledge.

This feels… desperate.
I also *hate* that I cannot trust ANY information coming out of this administration. Everything feels like disinformation.
Why would you enroll the President of The United States in effectively a unique clinical event by using TWO experimental drugs at the same time?

Is this for real? Or is it a hoax?

Or…

Is he sicker than they are letting on?
What do you mean, Sean Conley by saying “if he needs all 5 days of the treatment?”

Dude… it is an anti-viral regimen.

The only reason you’d end a regimen, is if there are medical complications.
Sean Conley sounded like a politician, or someone spreading propaganda… not like a physician.

Also: Was it 72 hrs ago that he got anti-body therapy? Or 48 hrs ago? This is bizarre.
Bizarre and totally bonkers implementation of medical care...
These numbers raise way more questions than they answer.

The best press conferences answer questions, not create new ones.
It was not 5th Ave where Trump was standing when he killed people, it was The Rose Garden:
Absolute reckless disregard, endangering the lives of so many:

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More from @BWJones

16 Dec 20
This is important. Make sure you click through and read to understand what I’ve been on about for the last 6yrs wrt modular NIH funding.

With no adjustment for inflation in two decades, we now have 55.5% of the purchasing power that we had in 2001 for biomedical research grants.
The implications of this are huge.

1) Scientists are having to hold *multiple* R01 grants just to keep on the treadmill.

2) This increases the risk of losing a grant non-linearly, resulting in destabilization of the discovery process.
3) Junior scientists applying for their first R01 need to understand that they *cannot* do the same amount of work that their mentors/predecessors did on the same grant mechanisms 20 years ago, or even 10 years ago.

4) Study sections need to recognize this and adjust accordingly
Read 15 tweets
14 Dec 20
Dealing with someone trying to get a COVID test here in Utah this morning...

The hoops they are having to jump through, just to try and get the test scheduled reveals precisely why our COVID case numbers are waaaaaay lower than my models suggest they are.

This is nuts.
We should be testing to saturation here, particularly given that we *know* people can be asymptomatic and still shed virus.
I hear from colleagues at @UCLA that employees on campus are getting screened twice/week whether they have symptoms or not.
Read 4 tweets
5 Oct 20
How does one normally handle a sociopath?

Should it be different, that the sociopath is the President of the United States?
P.S. Who put on his makeup for this outing? He clearly has makeup on.

Is it self applied? If not, who is the makeup person risking their life for this?
Trump was not discharged from medical care. He was transferred to the White House with a still active and raging COVID infection.

Think of all the people that work in the White House. Cleaners. Food service workers. Valets.

These people do not have infectious disease training.
Read 4 tweets
5 Oct 20
I will say that personal experience with dexamethasone was interesting.

After blowing out my back and getting surgery to decompress nerve roots, my doc said: “you’re gonna feel really good. I’ve loaded you full of dexamethasone... so be cool. Take it easy and don’t be stupid”.
Looks like the dexamethasone is kicking is kicking in…
Watching the video of Trump re-entering the White House makes me wonder if his physician has noted that Trump is not following advice.

I don’t know what the dosage is, but Trump is going to run into dexamethasone crash, and if it coincides with COVID viral spike, it could be bad
Read 4 tweets
4 Oct 20
The more I think about it, the more this makes me sad.

It is absolutely pathetic that the *image* of strength of competence is what this administration keeps pushing.

A beloved leader who sacrificed for his nation would be able to be seen in pajamas and taking it easy to heal.
Instead, we get fake images or propaganda scenes where the appearance of getting work done is more important than the actual work getting done, or of honesty in leadership.

One way or another, lies are being told here. The President has COVID, or he does not. It’s bad, or not...
I’d love to have a chat with the photographer, Joyce Boghosian, and get her perspective on all this...
Read 16 tweets

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