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dr a k chaurasia Profile picture
@drakchaurasia
Oct 7, 2020 • 10 tweets • 2 min read • Read on X
MY "LONG COVID PROTOCOL" DRUGS

*SPIRONOLACTON+FRUSEMIDE
*DEFLAZACORT/DEXAMETHASONE
*FAMOTIDINE
*INDOMETHACIN/ETORICOXIB
*CYPROHEPTADINE
*DIACEREIN
*HCQ/IVM
*N-ACETYLCYSTINE
*METOPROLOL/IVABRADINE(occasionally)
#mytakeoncovid19
MY "LONG COVID PROTOCOL" DRUGS - 2
(neurological)

*MODAFINIL
*FLUOXETINE
*L-DOPA
*CLONAZEPAM
*CORTICOSTEROIDS
*PREGABALINE/NORTRIPTYLINE
*CITICOLINE
#mytakeoncovid19
MY "LONG COVID PROTOCOL" - 3
(TREATMENT STRATEGIES)

*after 30 days, inflammatory mediators are subsided
*anatomical/physiological insults to organs is persisting
*organ specific injuries are treated accordingly (irrespective of original disease process)
1/1
1/2
 *with delayed/improper treatment some residual deficit is expected in organs and some prolonged neurological deficit may be expected.
yes dear, my take is that these are reversible. even in 6-7 months old cases, 90% recovery is expected. just treat it like diabetic neuropathy.

*long haulers are neurological symptoms, equivalent to toxic/metabolic neuropathy
*rarely, delayed/poorly treated, may be irreversible
PULSE THERAPY IN COVID DISEASE?
acute viral phase

*i recommend an antiviral treatment, 10-14 days
*using pulse therapy, one week each
*PULSE 1- HCQ+AZM+FEVIPIRAVIR
2- IVM+DOXY+ARTEMISIN
DIPYRIDAMOLE AND PENTOXYPHYLLINE
petoxyphylline is still my favourite, but now a day nobody use it so not available easily.
next to dipyridamole, it was my second choice in covid.
ACUTE COVID, FIRST LINE TREATMENT SCEDULE

1. IVM+DOXY+AMBROXOL-NAC+ACECLO-PARA-BROMELIN+RABEPRAZOL+CEFIXIM-CLAV

2. HCQ+AZM+AMBROX-NAC+ACECLO-PARA-BROM+RABEPRAZOL+CEFIXIM-CLAV

3.
 HCQ+FAVIPIRAVIR+AMBROX-NAC+ACECLO-PARA-BROM+RABEPRAZOL+CEFIXIM-CLAV
from archive
TO REDUCE/BREAK TRANSMISSION OF VIRUS

*mass chemoprophylaxis is key
*prophylaxis need not be 100%.partial prophylaxis is equally effective ~40-60%
*prophylaxis with sub-therapeutic dosage do contribute in cutting down transmission
*reducing fatalities is indicator
*any antiviral

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More from @drakchaurasia

dr a k chaurasia Profile picture
May 20, 2022
MONKEY POX - WHY NOW?
reactivation/lab leak?

"US Government researchers in 1950s were infecting monkeys with smallpox
Monkeypox was first seen in 1958, in monkeys used in medical experiments
first recorded human case occurred during a smallpox vaccination drive in Congo in 1970"
CIDOFOVIR VS ACICLOVIR
#akcmonkeypox

"It (cidofovir) has inhibitory effects on varicella-zoster virus replication in vitro although no clinical trials have been done to date, likely due to the abundance of safer alternatives such as aciclovir"
MONKEYPOX - ANALYSING THE AVAILABLE DATA

*demographic pattern is unusual
*least chances of dissemination through traveling
*reactivation is far-fetched since it was not endemic till now
*infectivity is low, disability is moderate
*WHY ONLY MONKEYPOX? we are having
1/1
Read 4 tweets
dr a k chaurasia Profile picture
May 19, 2022
U.S. MAY BE BARRELING TOWARD RECESSION IN NEXT YEAR

"western block is going to have 2009 like situation in near future.
great economical recession is impending, following ukr-russ war.
india will suffer least, west to go into great depression"
@NavroopSingh_
@TheTomar
HOW THE WAR IN UKRAINE IS ACCELERATING INDIA'S DESIRE FOR TECH AUTONOMY

"After 30 years of taking a backseat in the Indian political environment, protectionist understandings of the international political economy are now again gaining momentum"
thediplomat.com/2022/05/how-th…
Read 4 tweets
dr a k chaurasia Profile picture
Feb 12, 2022
#akcgenomics
TELOMERE SHORTENING
AND PREVENTING AGING BY CHEMICAL MEANS

"Berberine Inhibits Telomerase Activity and Induces Cell Cycle Arrest and Telomere Erosion in Colorectal Cancer Cell Line, HCT 116"
@drakchaurasia @Parsifaler
mdpi.com/1420-3049/26/2…
BERBERINE
Lewis rats were immunized with porcine cardiac myosin to induce experimental AUTOIMMUNE MYOCARDITIS,TREATED WITH BERBERIN nd specific JAK inhibitor
BERBERIN and AG490 significantly reduced impaired cardiac function and pathophysiological severity
BERBERINE IN LONG-COVID

*BRAIN FOGG
*POST-COVID TREMORS
*POST-COVID ATAXIA
*CFS/ MYALGIC ENCEPHALOMYELITIS
*TOXIC NEUROPATHY
Read 4 tweets
dr a k chaurasia Profile picture
Jan 18, 2022
#akcomicron
OMICRON-- DIFFERENT MODE OF CELL ENTRY
more cell types infected

"uses an endosomal pathway for entry that increases number of cell types it can infect. This switch of entry pathway could explain increase in transmissibility of Omicron variant"
news-medical.net/news/20220109/…
DRUGS BLOCKING ENDOCYTOSIS
omicron variants

*HCQ
*NITAZOXANIDE
OMICRON-- NEW TREATMENT HORIZONS
mefloquine and artemisins as new drugs inhibiting endocytosis

"Antimalarial Quinolines and Artemisinin Inhibit Endocytosis in Plasmodium falciparum"
journals.asm.org/doi/10.1128/AA…
Read 41 tweets
dr a k chaurasia Profile picture
Sep 11, 2021
#akccovid22
FINOFIBRATE IN COVID DISEASE
COMMON ANTI-PARASITIC AGENT EASES MOTOR SYMPTOMS, AIDS REMYELINATION IN MS MOUSE MODEL
IVM in autoimmune disease
"ivermectin eased clinical manifestations of experimental autoimmun encephalomyelitis (EAE;an induced autoimmune disease similar to MS in human
multiplesclerosisnewstoday.com/2018/07/13/ant…
POOR AB RESPONSE TO VACS OR NATURAL COV2 INFECTION

*pts on immunosuppressive drugs
*immunocompromised due to diseases like HIV
*neoplastic blood disorders, leukemia, lymphoma
*hereditary dysfunctions of T and B cells
Read 52 tweets
dr a k chaurasia Profile picture
Jul 6, 2021
LAMBDA VARIANT

"According to Public Health England (PHE),information about Lambda Variant Covid Symptoms is given below.According to PHE,no patient of this variant has had fatal disease so far.PHE reports that lambda version causes any major ill-effects"
mpnrc.org/lambda-variant…
Read 7 tweets

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