1/ THREAD on Sweden & "natural herd immunity":
COVID cases RISING in Sweden since August/September, as is the case across Europe. DEATHS are a LAGGING indicator (~6-8+ weeks after infections). It is likely Sweden will experience another SURGE in DEATHS in the coming weeks.
@celinegounder 2/ Like the U.S., Sweden FAILED to suppress virus transmission over the summer, in contrast to Sweden’s neighbors, like Norway and Germany. That was DESPITE many Swedes leaving urban and suburban areas for remote cabins in the summer.
@celinegounder 3/ Italy was hit hard and early. England initially took a herd immunity approach to the pandemic (the tallest peak). The U.S. and Sweden have almost identical curves. Sweden’s neighbors Norway and Germany sustained much smaller losses from COVID.
@celinegounder 5/ MANY severely ill patients WEREN'T HOSPITALIZED. On March 17th, Stockholm area hospitals were instructed not to admit anyone over the age of 80 or with a body mass index above 40 to intensive care. sciencemag.org/news/2020/10/i…
@celinegounder 6/ Most Swedish nursing home residents were NOT TAKEN TO HOSPITALS. Many nursing homes were unable to administer supplemental oxygen, so gave their residents MORPHINE INSTEAD. sciencemag.org/news/2020/10/i…
@celinegounder 7/ Stockholm’s nursing homes lost 7% of their 14,000 residents to the virus. In the U.S., we have ~1.4M nursing home residents. To put this in perspective, this would be equivalent to our having lost 119K nursing home residents. sciencemag.org/news/2020/10/i…
@celinegounder 8/ The Swedish Public Health Agency instructed people over age 70 to avoid socializing with others. In late March, the Swedish government banned gatherings of 50+ people and nursing home visits. jamanetwork.com/journals/jama/…
@celinegounder 9/ The Swedish Public Health Agency never ordered a shutdown or lock down, but strongly recommended social distancing, working from home, and avoiding unnecessary travel. jamanetwork.com/journals/jama/…
@celinegounder 11/ The Swedish Infectious Diseases Act can restrict individuals, but it does not allow for a general lockdown. This is why Sweden’s COVID mitigation measures have been recommendations rather than mandates. ncbi.nlm.nih.gov/pmc/articles/P…
@celinegounder 12/ But in contrast to Americans, Swedes have a high level of social and institutional trust. This means they’re more likely to comply with public health recommendations without mandates and strict sanctions.
@celinegounder 13/ An opinion poll in Sweden in early April found that 98% of respondents had changed their behavior to protect themselves from COVID. msb.se/sv/aktuellt/ny…
@celinegounder 14/ Though stores and restaurants remained open in Sweden, Google mobility tracking data suggests that Americans and Swedes decreased their visits to restaurants, cafes, and other retail / recreation locations at similar rates (-16% versus -12%).
@celinegounder 16/ Standing in lines / sitting at crowded tables at restaurants / bars not allowed. Guests served at their table & urged to stay at least 1 meter away from other parties. Many restaurants & bars were closed for violating this guidance. onlinelibrary.wiley.com/doi/10.1111/ap…
@celinegounder 17/ The Swedish government kept open daycare centers and primary schools (NOT secondary schools, colleges, and universities, which went online).
@celinegounder 18/ Note that children 10 and under seem to be less likely to transmit coronavirus to adults.
@celinegounder 19/ Anders Tegnell, chief epidemiologist for the Swedish public health authority, was concerned about recommending face masks in public because such advice “would also imply that the spread is airborne.”
@celinegounder 22/ Swedish health authorities estimate that <12% of residents in Stockholm and 6-8% of residents nationwide had COVID antibodies by mid-June. sciencemag.org/news/2020/10/i…
@celinegounder 23/ This is nowhere near high enough to achieve herd immunity. Furthermore, if natural immunity lasts at best 2-3 years, “natural herd immunity” is simply not a realistic strategy. jamanetwork.com/journals/jama/…
@celinegounder 24/ What’s been the impact of the pandemic on Sweden’s economy? In the 1st half of 2020, Sweden’s GDP fell by 8.5%—less than in neighboring Germany, but MORE than in neighboring countries Norway and Finland. Also less than in the U.S. washingtonpost.com/outlook/2020/1…
@celinegounder 25/ Sweden’s central bank forecasts the nation's economy will contract by 7-10% in 2020. The EU commission forecasts an economic contraction for the eurozone of 7.75% in 2020. ESSENTIALLY THE SAME. politico.eu/article/sweden…
@celinegounder 26/ Was the Swedish strategy worth the cost? In @WashingtonPost, Stockholm University’s international economics professor Lars Calmfors did a quick back of the envelope calculation looking only at deaths from COVID. washingtonpost.com/outlook/2020/1…
@celinegounder 27/ The Swedish approach is “profitable” if each life lost is worth less than $1.12M. This doesn’t take into account the cost of COVID long-haulers, etc. washingtonpost.com/outlook/2020/1…
@celinegounder 28/ It’s also important to note that Sweden—unlike the U.S.—has social and economic safety nets and a central, publicly funded healthcare system with universal coverage. washingtonpost.com/outlook/2020/1…
@celinegounder 30/ Without Sweden's more generous social and economic safety nets and healthcare system, a “natural herd immunity” strategy will likely be MORE destructive to public health and the economy in the U.S. than it has been in Sweden.
@celinegounder 31/ In summary, the Swedish approach wasn’t really a “natural herd immunity” approach. But the Swedish strategy was highly costly with respect to cases and deaths with little economic benefit.
@celinegounder 32/ Cumulative confirmed COVID deaths per million people (does not include deaths due to COVID where testing was not performed):
U.S. 679.45
Sweden 587.47
Denmark 120.85
Germany 119.74
Finland 63.71
Norway 51.46
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1/ LOVELY in THEORY, but herd immunity WILL NOT work:
POTUS "vowed to shield America’s senior citizens from the coronavirus & directed them to stay home amid the pandemic" politico.com/news/2020/10/1…
2/ Measles has infected humans since at least the 9th century. Smallpox? Since the 3rd century BC. Both are respiratory viruses, like coronavirus.
3/ We have yet to eradicate measles via natural infection & immunity. We only reached herd immunity to smallpox with a vaccine & a MASSIVE eradication effort. When you let respiratory viruses like measles, smallpox, and coronavirus spread naturally, you get big epidemic spikes:
1/ Late last month, Dr. Bill Foege—@CDCgov Director '77-83, central figure in smallpox eradication, former Task Force for Global Health & Carter Center leader, Senior Fellow at the @gatesfoundation, and a devout Christian—sent this plea to @CDCDirector Bob Redfield.
2/ We are witnessing a "colossal failure of the public health response in this country." The result of "incompetence and illogic." The @CDCgov is the preeminent public health institution in the world. They should have been leading the response from the beginning.
3/ Basic tenets of public health:
- "Know the Truth." This White House is about obfuscation & confabulation.
- "a coherent FEDERAL plan," not a patchwork response: podcasts.apple.com/us/podcast/epi…
- We need cooperation & coalition, not division. The virus is winning by divide & conquer.
1/ Great speaking with @Elemental's @smithdag today. elemental.medium.com/everything-we-…
Some highlights:
- “If the fever came down on its own, that’s a very good sign prognostically. If the fever required medication to come down […] it wouldn’t necessarily mean he’s getting better..."
2/ Steroids like dexamethasone and medications like aspirin, Tylenol, and ibuprofen will reduce a fever.
3/ On Fri/Sat, Trump had an oxygen saturation below 94%. Dr. Conley said it didn't got down to the low 80s. So that would imply it dropped to the upper 80s.
1/ POTUS says he's leaving Walter Reed and going back to the White House: washingtonpost.com/elections/2020…
Assuming he got sick Wed/Thurs, he's on day 5 or 6 of COVID. It's too early.
2/ On day 2 or 3 of COVID POTUS already had evidence of severe COVID with oxygen saturation under 94% on room air (& likely into upper 80s) & supplemental oxygen requirement.
3/ COVID patients often get worse at 7-10 days into illness (i.e. this Fri or Sat). I hope that doesn't happen. But he should be closely monitoring in a hospital NEAR AN INTENSIVE CARE UNIT until then.
1/ It's concerning that President Trump got so sick so quickly. Here's my take for @CNN: cnn.com/2020/10/04/opi…
2/ Today we learned that POTUS had a fever & an oxygen saturation level below 94% on Friday morning, prompting his transfer to Walter Reed. Reading between the lines of what Dr. Conley did & did not say, it's possible that the POTUS' oxygen levels dropped into the upper 80s.
3/ He again had a drop in his oxygen saturation level to 93% Sat AM. It is unclear whether he again was given supplemental oxygen at that time. He is now on at least 3 medications for severe COVID, including Regeneron's monoclonal antibody cocktail, remdesivir & dexamethasone.
1/ What did we learn about the President's health today?
- He had a fever and oxygen saturation level under 94% on Friday, which prompted his transfer to Walter Reed Hospital.
- His oxygen saturation dropped Saturday AM. He was started on dexamethasone.
2/
- The President's kidney & liver function have remained normal.
- His cardiac function is normal or improving? Was it ever abnormal? We know he's had an ultrasound. Was this an ultrasound of the heart (echocardiogram)?
3/ - He received Regeneron's monoclonal antibody cocktail on Thursday.
- He was started on remdesivir on Friday and dexamethasone on Saturday.