A groundbreaking paper by @younis_sh1 et al. @stanfordimmuno provides an answer to the long-standing question about how EBV infections are linked to lupus. A short thread to explain the key findings. (1/) science.org/doi/10.1126/sc…
The authors developed a new method called EBV-seq, enabling them to overcome the barrier of studying rare cells (~25 per 10,000 B cells in lupus patients) that are infected by EBV. Note that in healthy people, only 1/10,000 B cells are EBV-infected. (2/)
First, the authors found that EBV infects autoreactive B cells that express anti-nuclear antibodies in lupus patients, but not in healthy people or in patients with multiple sclerosis. (3/)
Today @TheNewYorker released our short documentary “Rovina’s Choice."
It traces the ongoing effects of the sudden shutdown of US foreign aid through the story of one mother in Kenya as she seeks to save her daughter from sickness and starvation. 🎥 1/ newyorker.com/culture/the-ne…
I’ve written a companion piece explaining the film’s context: USAID’s dismantling is estimated to have already killed 600,000 people, ⅔ of them children. Officials simply deny any harm, while halting data monitoring and firing inspectors general who’d have documented it. 2/
Consider malnutrition. USAID helped countries shift care from hospitals to nearer home. Health workers with a scale & tape measure detect bad cases earlier. A peanut-paste therapy reversed starvation. Deaths fell from 20% to as little as 1%. It saved 1.2M lives in 2023. 3/
- Displaced people reaching Tawila today (a town west of Fasher, where there is some relief presence) report that massacres of civilians along ethnic lines have begun
- Very few ppl are able to flee
More:
- Civilians attempting to escape El Fasher are being gunned down by RSF as they flee
- RSF is funneling people toward the east rather than allow them west toward Tawila
- RSF carrying out mass detentions in town
- No aid getting in - many people are too run down to flee
CDC is not a Democratic or Republican agency. It's an American agency. One in three employees have been lost in recent months. This is dismantling of our health protections, not reform.
The administration talks about making America healthier, about transparency and quality science. But the plain truth is that they’re doing the opposite.
They're systematically destroying the systems that keep Americans safe from diseases and health threats, making and reversing life-and-death decisions with no transparency or discussion, and undermining science.
Donald Trump is now addressed the UN General Assembly. He notes the teleprompter isn't working and, "whoever is responsible for this teleprompter is in big trouble."
He reads from printed text on the podium.
"This is the Golden Age of America."
2/ His remarks open by listing his accomplishments domestically since taking office. "In my first term I built the best economy in the history of the world...and this time it's even better."
"The number of illegal aliens entering our country has reached zero...If you come illegally into the U-S you're going to jail...or perhaps further. You know what that means."
3/Trump at UNGA
Says the U.S. was a laughing stock, but not anymore. My administration has negotiated one historic trade agreement after another."
I have ended 7 un-endable wars. I ended 7 wars. " Cambodia/Thailand, Congo/Rwanda, Armenia/Azerbaijian, Albania/Kosovo.
"And I did it in just 7 months. There's never been anything like it."
The UN "did nothing. I never even received a phone call from the U-N."
Canadian PM Mark Carney is addressing the Council on Foreign Relations right now. He opened by describing the very positive relationship Canada and the US shared -- until now.
And looking at Trump impacts on the global geopolitical landscape.
"So, what do we do about it? We think we can thrive for three reasons"
1.) we have what the world wants:
- energy
- we are top % in world's critical minerals
- we are a leading developer of AI and quantum talent
- we have sophisticated pension funds and investors
- we have a govt that can act decisively
2.) Our public square is loud, diverse and free
3.) We recognize what's going on. A rupture. Sharp change.
- build strength at home, cut taxes, increased X-province trade, doubling defense spending, especially in AI
- defend out values
- build alliances abroad
- diverse trade agreements, espec. w/EU
- joining SAFE -- EU defense
- comprehensive approach w/Mexico trade
- we are largest contributor per capita to Ukraine
- support 2-state solution in ME
- forming buyers' clubs for REEs & critical minerals
MORE
Carney/2
"Old Multilateralism" -- how we used to work.
Now, substantial change underway, espec. for REEs, essential minerals, energy.
When you think about Canada, think of a strong soveriegn nation.
We understand what's going on. We have the resources the world needs. We're a reliable partner...with any part of the world.
Carney/3
LIVE now Carney is talking on stage w/CFR Pres. Froman
Q - 2/3rds Canadian population lives w/in 100 km of US border -- how much can you reorient economy?
Carney: 1st, recog. the need to do it. To be masters in our own house.
Don't want to look at Truth Social daily to see changes in US poilicy
MORE
I watched the 1st meeting day of RFK Jr’s handpicked committee of vaccine advisors that encapsulates the proceedings. It was utterly depressing. 1/
Liaisons from medical societies asked repeatedly: what is the reason for the votes to now change children’s routine vaccine schedules when there’s been no signal of harm and clear evidence of great benefit? 2/
Finally, an answer came back: we must make changes because trust in vaccines has decreased. “The signal that is prompting this is not one of safety, but one of trust,” said member Robert Malone. 3/
On Tuesday on the hill, Sen. Ron Johnson touted results from an unpublished study commissioned by an anti-vaccine group as showing the risk of childhood vaccines.
I asked why the study hadn't been published of Henry Ford Health, where the author who did not testify worked.
A spokesperson told me that "an initial peer review of the draft revealed immediate and significant concerns due to serious data flaws" and that the institution "was unaware this long-rejected and unvalidated draft was being talked about or had somehow been shared."
The spokesperson said the institution was not given the opportunity by Congress to weigh in or testify.
"In the end, this report was not published because it did not even come close to meeting the rigorous scientific standards we demand—not because of the results."
At first blush this story almost seems too outlandish to be real. Full disclosure - I was skeptical when I first hear these rumblings a few months ago.
But BBC brings the receipts. And the receipts are flat-out nuts (this nugget about gang leader Johnny Mulford is priceless).
Who is Mulford, the lead GHF security subcontractor?
He's a biker gang leader who was formerly debarred by the Pentagon for "bribery, larceny, and making false official statements" related to contract kickbacks.
On Friday, when most of America wasn't paying attention, heading out for the holidays, Trump signed an Exec Order transferring ALL control over foreign aid from State to OMB.
This will destroy American overseas programs. Here's why (MORE)whitehouse.gov/presidential-a…
2/US programs for everything from #famine relief & #HIV care to safe pregnancy efforts & building electricity grids have won America friends in the world & saved 100s of millions of lives. They were nested in the State Dept so our diplomats on the ground can oversee them.
MORE
3/ By moving foreign aid out of State & into OMB, programs for saving starving children, rescuing families from catastrophes, teaching kids to read, stopping epidemics -- ALL of that now falls under the control of Russell Vought.
Who is Vought?
MOREtrumpwhitehouse.archives.gov/people/russell…
During the pandemic, it became clear that the CDC lost the mission. It needed a realignment.
More from @US_FDA Commissioner @DrMakaryFDA🧵
It's time to rebuild public trust after the scientific intolerance and extreme partisanship of the Biden Administration.
.@US_FDA is implementing a risk-stratified approach in ending emergency use authorization for COVID-19 vaccines – finally catching America up to the rest of the world.
1/ The 2024 Medicare Shared Savings Program results are released from embargo!
topline results:
10,326,340 bene-years (12% @AledadeACO )
$6,452,075,989 in savings versus benchmark
$4,062,804,612 in payments to ACOs (19% Aledade)
Largest savings ever
Higher quality than FFS🎉
2/ fact sheet:
$643 (2024) vs $515 (2023) in gross per capita savings
Almost 2x savings rate for "low revenue ACOs" (physician-led/FQHC/RHCs) and for those composed predominantly of primary care clinicians vs high revenue ACOs (typically hospital-led)
"lower utilization compared to their benchmark across many categories of utilization including hospital discharges, Emergency Department visits and Skilled Nursing Facility stays"
Better chronic disease management
More prevention
Less suffering
We examined spike of KP.3.1.1, a strain from late 2024 / early 2025 similar to current variants
KP.3.1.1 & other recent variants have >60 spike amino-acid mutations relative to early pandemic strains, as spike has evolved at extraordinary rate of >10 mutations/year on avg
We previously developed pseudovirus deep mutational scanning (), which uses non-replicative viral particles to safely study spike mutations.
Here we used approach to measure how mutations to KP.3.1.1 spike affect five phenotypes, as shown below. pubmed.ncbi.nlm.nih.gov/36868218/
As I wrote in SUPER AGERS, the immune system is the key to modulating our aging process and the opportunity to extend healthspan. Today @NatureAging 7 new articles, summarized here, that reinforce its central role nature.com/articles/s4358…
.@NBCNews claims that @SecKennedy's recommendation to fry potatoes in beef tallow - rather than the seed oils used today - "isn’t backed by scientific research."
Here is a basketful of studies that tell a different story: 🍟1/7
• Beef tallow, rendered suet from a cow, is known to contain high levels of saturated fatty acids (SFAs), which can also be found in coconut oil and dairy products.
• Ultra-processed seed oils, such as those derived from rapeseeds ("canola") and soybeans, contain higher levels of polyunsaturated fatty acids (PUFAs). 🍟2/7
Foods such as wild blueberries and carrots are praised for their high levels of antioxidants, which have been shown to protect the human body from the free radicals linked to many chronic health conditions.
By contrast, the PUFAs found in seed oils are "particularly susceptible to oxidative damage" and produce "aldehydes," which "exert a range of toxicological effects," during the frying process.
The new special issue @ScienceMagazine features Immunity with 4 outstanding review papers, 5★
Our immune system over the lifespan, sex differences, influence on physiology, and host antiviral defenses science.org/toc/science/cu…
The world's famine alert system is warning us – in the starkest possible terms – that any remaining window to avert mass starvation deaths in Gaza is about to close.