1/7 Lots to unroll on #ASH20SU #ASH20 #mmsm abstracts, will do in several categories:

TOP TRANSLATIONAL
-ImmunoCell Study (ash.confex.com/ash/2020/webpr…)
-Discordance btwn IFE and MRD (ash.confex.com/ash/2020/webpr…)
@theMMRF @IMFmyeloma @Myeloma_Society @ASH_hematology
2/7 #ASH20SU #ASH20 #mmsm
-Immune ME Changes from MGUS/SMM to active MM (ash.confex.com/ash/2020/webpr…)
-PCL Genome/Transcriptome (ash.confex.com/ash/2020/webpr…)
-Resistance to BCMA Therapy (ash.confex.com/ash/2020/webpr…)
-Immunogenomic heterogeneity in MM (ash.confex.com/ash/2020/webpr…)
4/7
TOP CLINICAL CART PHASE 1 RRMM #ASH20SU #ASH20 #mmsm
-Cilta-cel (ash.confex.com/ash/2020/webpr…)
-Anti-BCMA & Anti-CD52 Allo-CART (ash.confex.com/ash/2020/webpr…)
-BB21217 (ash.confex.com/ash/2020/webpr…)
-CT053 (ash.confex.com/ash/2020/webpr…)
-P-BCMA-101 (ash.confex.com/ash/2020/webpr…)
5/7
TOP CLINICAL PHASE 2/3 RRMM #ASH20SU #ASH20 #mmsm
-Ixa-Kd IKEMA Update (ash.confex.com/ash/2020/webpr…)
-Dara-Pod APOLLO (ash.confex.com/ash/2020/webpr…)
-Dara-Kd CANDOR Survival Update (ash.confex.com/ash/2020/webpr…)
6/7
TOP 5 CLINICAL PHASE 2/3 Newly Diagnosed #ASH20SU #ASH20 #mmsm
-GRIFFIN Update (ash.confex.com/ash/2020/webpr…)
-EMN02/HO95 Update (ash.confex.com/ash/2020/webpr…)
-ANDROMEDA (ash.confex.com/ash/2020/webpr…)
-FORTE Survival Analysis (ash.confex.com/ash/2020/webpr…)
7/7
HONORABLE MENTIONS #ASH20SU #ASH20 #mmsm
-K-Cy-Dex vs Kd (ash.confex.com/ash/2020/webpr…)
-Dara-Cy-Dex +/- Pom (ash.confex.com/ash/2020/webpr…)
-1q21 Story in FORTE Trial (ash.confex.com/ash/2020/webpr…)
-Genomic/Transcriptomic Analysis on BELLINI Trial (ash.confex.com/ash/2020/webpr…)

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More from @szusmani

10 Sep
The chromosome 1q21 story (1/10):
-Having extra copies of generally odd num. chromosomes constituents hyperdiploidy #mmsm , recognized as ‘HY’ in GEP based molecular classification.
-Having 3 copies is called ‘gain 1q21’
-Having >=4 copies is called ‘amplification of 1q21’.
The chromosome 1q21 story (2/10):
-Herve Avet-Louiseau identifies 1q21 ‘enhancement’ in human MM cell lines, primary MM cells and plasma cell leukemia (PMID: 9172003), Shaughnessy et al corroborate (PMID: 15472896).
- Gain/Amp ch. 1q21 first recognized as poor prognostic markers
The chromosome 1q21 story (3/10):
...in MM by Arkansas group in mid-2000s (PMID: 16188652, PMID: 16705089)
- Corroborated by other groups (PMID: 16995883, PMID: 17024118, PMID: 20537706, PMID: 21523726) in the context of pre-novel and doublet novel induction/transplant era.
Read 10 tweets

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