Ten #ASH20 #MultipleMyeloma abstracts that I think will most inform my clinical practice [π»πππππ
] #1/11 #mmsm
1. Another trial [ππΆπΉπ»π¬] shows meaningful PFS benefit with early ASCT [after KRD], irrespective of cytogenetic risk. (Despite similar early MRD-negative rates in both arms) tinyurl.com/y4re2gpw #mmsm 2/11 
2. Long-term follow-up of bb2121 [Ide-Cel] at a median of 15 months: Median PFSβ‘οΈπ π¦π¨π§ππ‘π¬. At 450 x 106 dosing, β80% β₯VGPR and β40% CR. Hope to get @FDAOncology approval soon?? tinyurl.com/y4lwcvjy #mmsm 3/11
3. EMN02/HO95 trialβ‘οΈOS benefit emerges in the ASCT arm after 75 months follow-up, with curves starting to split after 3 years (Despite 63% relapsed pts. getting delayed ASCT). πͺπππππ: Induction was VCD [not VRD] tinyurl.com/y3r8hef4 #mmsm 4/11
4. Long-term f/u of IFM-09 trial [mF/U: ππ π¦π¨.!!] shows no OS benefit of early over delayed ASCT [β75% in the delayed ASCT arm received one at 1st relapse]. Take home: If VRD induction + consolidation, ok to delay ASCT to 1st relapse. tinyurl.com/y5onx7n6 #mmsm 5/11
5. Multi-center study on 359 patients with ππ’π π‘π ππ‘ππ’π§ πππ©π¨π¬π’ππ’π¨π§ ππ’π¬πππ¬π: dFLC<40 mg/L @ 6 mo.β‘οΈBetter PFS and OS. Degree of proteinuria [>2.5 gm/24 hours] and BMPC [>20%] predicted renal survival and overall survival tinyurl.com/y6y36vqf #mmsm 6/11
6. With increased Daratumumab use front-line, great to have a risk-prediction model for early severe infections: π΄ππ, πΏπ·π», π΄πππ’πππ, πππ π΄πΏπ πππ£ππ. Grade 3 or higher infections in high-risk patients: ππ.π%!! tinyurl.com/y2ysg63x #mmsm 7/11
7. Another BCMA-ADC MEDI2228 with single-agent ORR of 60% [24% VGPR] with distinct toxicity profile compared to BlenRep [no keratopathy], cytotoxic payload [PBDβ‘οΈDNA cross-linking], and preferably binds to membrane-bound [vs circulating] #BCMA tinyurl.com/y3dssxvh #mmsm 8/11
8. Prospective assessment from FORTE trialβ‘οΈHigh burden of πͺππππππππππ π·πππππ πͺππππ by MFC at diagnosis adversely impacts PFS/OS, however, can be overcome by post-treatment MRD-negativity tinyurl.com/y3mq3bg7 #mmsm 9/11
9. Correlation of Whole Body DW-MRI and Bone Marrow MRD [10-5 sens.] shows bi-directional discordance β‘οΈImportant to check for MRD both inside and outside bone marrow. Double-negative patients do best. tinyurl.com/yxorg9gs #mmsm 10/11
10. FORTE trial again!! TMK, first RCT data on π·π° + π°π΄ππ« ππ π°π΄ππ« maint.β‘οΈSuperior PFS with KR [vs R], as expected, but β¬οΈed tox., including cardiac and TMA with carfilzomib. Will it translate into OS benefit with longer f/u? #mmsm tinyurl.com/yxorg9gs 11/11 END
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