Aman Thind Profile picture
Nov 14, 2020 6 tweets 4 min read Read on X
1/
I've heard this argument before that "an amp of sodium bicarb raises blood pressure as it is hyperosmolar". I thought it'd be a good idea to quantify its effects:

Let's consider an average 70kg adult with TBW = 42L, ICFV = 25L (60%), and ECFV = 17L (40%), osmolality = 280. Image
2/
1 amp of bicarb=50 meq of Na and 50 meq HCO3 --> a total of 100 mosm of solutes are added. A key point is that all new osmoles remain in ECF-->ECF osmoles increase to 4860 mosm

To predict changes after equilibration, we have to look at changes in total body solutes and water.
3/
Total body solutes now increase to 11860 mosm from 11760 mosm. TBW increases only by 50cc (the volume of 1 amp).
So after equilibration, new osmolality should be 11860/42.05 = 282.05 mosm/L

Now let's see how the 2 compartments would settle after equilibration (figure) Image
4/
So after equilibration, ECFV is increased by ~230cc. I would imagine this equilibration does not occur instantly but takes some time (?few minutes). One may thus think of 1amp NaHCO3 as equivalent to 230cc of a slow NS bolus

Augmentation of intrasvascular volume would be ~25%
5/ Hence, the projected increase in intravascular volume = 230/4 = 57.5cc (over a few minutes). This may be lower in pathological states (leaky capillaries etc)

Besides, this argument assumes that the patient is preload responsive, which is true for only a fraction of the cases.
Overall doesn't look like it should have a drastic hemodynamic effect.

Am I missing something here? Would love to hear what #NephroTwitter thinks.

@NephroGuy @kidney_boy @ArgaizR @mahrukhrizvi_MD @NephroMD @VelezNephHepato @ansakhuja

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More from @Thind888

Jan 31
This generated some great discussion. Now let's do a deep dive

The first odd thing here is the Paw waveform. Traditional teaching is that in VC with continuous flow, the initial ⬆️in Paw corresponds to the pressure required to overcome resistance (as lung filling is minimal)

1/
Since flow is constant, this 'resistive pressure' remains constant throughout the breath as revealed by the post-inspiratory pause (image 1)

Hence, the height of the initial Paw spike should equal the height of PIP - Pplat. This is not the case in our patient!

2/
Image
Image
In our patient, the initial ⬆️ in Paw is >> PIP - Pplat (let's call this pattern X). This implies that in the beginning of the breath, pressure is being spent not just to overcome the resistive load, but also on something else. But what?

Let's talk about 'airway closure'.

3/ Image
Read 17 tweets
Oct 19, 2023
As promised, here's a summary (?X-torial) from my talk at @accpchest this year.
The main objective was to do a primer on respiratory mechanics and understand how the information obtained from the esophageal balloon can be useful.

There are a lot of pressures in mechancial ventilation. It is important to understand their physiological meaning.
Image
Image
1. Peak pressure:

This (along with Pmus) is the fuel that drives ventilation. More on equation of motion -

As such, peak pressure includes contribution from both resistive and elastic (+mass) loads.

Resistive pressure has no relevance for lung stress. criticalcarenow.com/equation-of-mo…

Image
Image
Read 13 tweets
May 3, 2023
Paging ENTtwitter & AirwayTwitter. Had a patient with moderate subglottic stenosis s/p recent dilation Intubated twice post-dilation for episodic stridor. During the second episode, scope showed laryngospasm. How common is this in non-OR (ICU) setting? Any tips on prevention/Rx?
Further clarification -
Patient was fine immediate post op. First episode occurred the next day. Extubated after 2 days - did fantastic for 10 minutes and then raging stridor. ?Precipitated by deep oral suctioning.

Scope showed laryngospasm. Improved some with PPV but needed RSI
Read 11 tweets
Feb 26, 2023
**Volumetric capnography: data points & equipment**

🧵[1/20]

There are three major reasons for limited utilization of volumetric capnography (VCap):
(1) Lack of education/training
(2) Lack of understanding of the data
(3) (Perceived) lack of equipment

Lets try to address 2 & 3
Let's start with a TL;DR of what VCap is:

Conventional capnography is 'time-based': Time on the X-axis and pCO2 on the Y-axis.

VCap has volume on the Y-axis.

VCap requires simultanoues measurement of exhaled pCO2 and expiratory flow.
*VCap data points*
VCap provides several data points: some more useful than others.

(i) PECO2: Mixed expired CO2 pressure (mmHg):
This is simply the “volume-averaged” CO2 of the pCO2-volume curve: the mean pCO2 of expired gas.

(ii) VTCO2: Volume of CO2 expired in a breath (cc):
Read 21 tweets
Jun 5, 2022
This brilliant thread has me get my proceduralist nerd on. Continuing the conversation -

(I) Although French and Gauge typically refer to outer diameters of needles/catheters, there are exceptions:

A. When describing luminal dimensions of a multilumen catheter...
..In this case, the 'gauge' refers to the luminal diameter (image 1),

B. By convention, the size label of a percutaneous sheath introducer (PSI) (e.g. Cordis) refers to its inner diameter. This is because the whole purpose of a PSI is to allow introduction of another catheter...
...Hence, the size label of a PSI serves as a guide for the size of the catheter that should be introduced through it

Take the example of a MAC introducer. Although the label reads 9Fr, this is in fact the inner diameter of the bigger lumen. The outer diameter is actually ~14Fr!
Read 11 tweets
Nov 22, 2021
@cjosephy @icmteaching @vaszochios @msiuba @IM_Crit_ @emireles_c @MegriMohammed @HamiltonMedical @ecgoligher @drhaty Ah, it's too complicated for a twitter thread, Clay, but I'll give it a shot!

Nomenclature is key. Ptp = Airway pressure (Paw) - Pleural pressure (Ppl);

*not* alveolar pressure (Palv) - Ppl, as often misquoted.

Hence, Ptp = transairway pressure + transalveolar pressure. Image
@cjosephy @icmteaching @vaszochios @msiuba @IM_Crit_ @emireles_c @MegriMohammed @HamiltonMedical @ecgoligher @drhaty When we're trying to assess lung stress, what we really want to determine is 'transalveolar pressure'.

Now here's the kicker -
In the absence of airflow, transairway pressure is zero. In this state, Ptp equals transalveolar pressure!
@cjosephy @icmteaching @vaszochios @msiuba @IM_Crit_ @emireles_c @MegriMohammed @HamiltonMedical @ecgoligher @drhaty In other words, Ptp reflects lung stress only in zero flow states e.g. end-inspiratory hold performed to check Pplat. Hence, "Pplat - Ppl" is a great marker of end-inspiratory lung stress.

Now back to Pocc:
We can determine "peak" Ptp using this method.
Read 4 tweets

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