1/ I've heard this argument before that "an amp of sodium bicarb raises blood pressure as it is hyperosmolar". I thought it'd be a good idea to quantify its effects:
Let's consider an average 70kg adult with TBW = 42L, ICFV = 25L (60%), and ECFV = 17L (40%), osmolality = 280.
2/ 1 amp of bicarb=50 meq of Na and 50 meq HCO3 --> a total of 100 mosm of solutes are added. A key point is that all new osmoles remain in ECF-->ECF osmoles increase to 4860 mosm
To predict changes after equilibration, we have to look at changes in total body solutes and water.
3/ Total body solutes now increase to 11860 mosm from 11760 mosm. TBW increases only by 50cc (the volume of 1 amp).
So after equilibration, new osmolality should be 11860/42.05 = 282.05 mosm/L
Now let's see how the 2 compartments would settle after equilibration (figure)
4/ So after equilibration, ECFV is increased by ~230cc. I would imagine this equilibration does not occur instantly but takes some time (?few minutes). One may thus think of 1amp NaHCO3 as equivalent to 230cc of a slow NS bolus
Augmentation of intrasvascular volume would be ~25%
5/ Hence, the projected increase in intravascular volume = 230/4 = 57.5cc (over a few minutes). This may be lower in pathological states (leaky capillaries etc)
Besides, this argument assumes that the patient is preload responsive, which is true for only a fraction of the cases.
Overall doesn't look like it should have a drastic hemodynamic effect.
Am I missing something here? Would love to hear what #NephroTwitter thinks.
This generated some great discussion. Now let's do a deep dive
The first odd thing here is the Paw waveform. Traditional teaching is that in VC with continuous flow, the initial ⬆️in Paw corresponds to the pressure required to overcome resistance (as lung filling is minimal)
Since flow is constant, this 'resistive pressure' remains constant throughout the breath as revealed by the post-inspiratory pause (image 1)
Hence, the height of the initial Paw spike should equal the height of PIP - Pplat. This is not the case in our patient!
2/
In our patient, the initial ⬆️ in Paw is >> PIP - Pplat (let's call this pattern X). This implies that in the beginning of the breath, pressure is being spent not just to overcome the resistive load, but also on something else. But what?
Paging ENTtwitter & AirwayTwitter. Had a patient with moderate subglottic stenosis s/p recent dilation Intubated twice post-dilation for episodic stridor. During the second episode, scope showed laryngospasm. How common is this in non-OR (ICU) setting? Any tips on prevention/Rx?
Further clarification -
Patient was fine immediate post op. First episode occurred the next day. Extubated after 2 days - did fantastic for 10 minutes and then raging stridor. ?Precipitated by deep oral suctioning.
Scope showed laryngospasm. Improved some with PPV but needed RSI
**Volumetric capnography: data points & equipment**
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There are three major reasons for limited utilization of volumetric capnography (VCap): (1) Lack of education/training (2) Lack of understanding of the data (3) (Perceived) lack of equipment
Lets try to address 2 & 3
Let's start with a TL;DR of what VCap is:
Conventional capnography is 'time-based': Time on the X-axis and pCO2 on the Y-axis.
VCap has volume on the Y-axis.
VCap requires simultanoues measurement of exhaled pCO2 and expiratory flow.
*VCap data points*
VCap provides several data points: some more useful than others.
(i) PECO2: Mixed expired CO2 pressure (mmHg):
This is simply the “volume-averaged” CO2 of the pCO2-volume curve: the mean pCO2 of expired gas.
(ii) VTCO2: Volume of CO2 expired in a breath (cc):
..In this case, the 'gauge' refers to the luminal diameter (image 1),
B. By convention, the size label of a percutaneous sheath introducer (PSI) (e.g. Cordis) refers to its inner diameter. This is because the whole purpose of a PSI is to allow introduction of another catheter...
...Hence, the size label of a PSI serves as a guide for the size of the catheter that should be introduced through it
Take the example of a MAC introducer. Although the label reads 9Fr, this is in fact the inner diameter of the bigger lumen. The outer diameter is actually ~14Fr!