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Derek Lowe

16 Nov, 4 tweets, 1 min read

Absolutely wonderful news from Moderna: 94% vaccine efficacy, zero severe coronavirus cases, no severe adverse events, and one-month stability under standard refrigeration.

We’re winning. Hang on, hang on, hang on and stay safe. We’re going to win.

Here are the details: investors.modernatx.com/news-releases/…

Thoughts on the Moderna results this morning - safety, efficacy, and more. The vaccine news is very good, especially when it's illuminated against grim pandemic news in general: blogs.sciencemag.org/pipeline/archi…

As the blog says, there are some Grade 3 safety events with the Moderna vaccine. That's roughly "enough to keep you in bed, but not to send you to the hospital" level: muscle and joint pain, etc. Looks similar to GSK's Shingrix effects, at first glance.

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Derek Lowe

@Dereklowe

7 May

You may have seen claims from people promoting hydroxychloroquine that there are numbers from Italy that prove that it's a prophylactic treatment against COVID-19. These numbers are complete fiction. (1/5

There are at least two mentions in media sources (one from an Italian newspaper, one from an interview in the Israeli press) about the Italian Rheumatology Society monitoring their patients who are taking HCQ for coronavirus cases. (2/5)

These sources say that 65,000 such Italian patients have been monitored and that only 20 of them have been diagnosed positive. *This is false*. I dug into the numbers here, and they did not add up (3/5):
blogs.sciencemag.org/pipeline/archi…

Read 5 tweets

Derek Lowe

@Dereklowe

23 Feb

(1/x) A little history and politics. Folks looking for a science/chemistry thread can skip this one!

(2/x) The Roman Republic took quite a while going off the rails. But eventually (80 BC) a powerful politician and general (Sulla) took over in what can only be described as a military coup, to restore order.

(3/x) He was declared "dictator for the making of laws and for the settling of the constitution". The Republic had been very wary of every vesting power in a single leader, but here it was. He wasted no time exercising his powers.

Read 11 tweets

Derek Lowe

@Dereklowe

19 Nov 19

(1/x) Noted without further comment, this passage from Alexander Hamilton, in a letter to George Washington from August of 1792. The fuull document can be found here:
founders.archives.gov/documents/Hami…

(2/x) "When a man unprincipled in private life, desperate in his fortune, bold in his temper, possessed of considerable talents, having the advantage of military habits—despotic in his ordinary demeanour. . .

(3/x)". . .known to have scoffed in private at the principles of liberty—when such a man is seen to mount the hobby horse of popularity—to join in the cry of danger to liberty—to take every opportunity of embarrassing the General Government & bringing it under suspicion. . ."

Read 4 tweets

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