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Gertrud Rey PhD (Trudy)

@GertrudRey

25 Nov

Several people have expressed concern over the Pfizer/Moderna vaccines because of their mRNA composition and the alleged possibility that this mRNA could integrate into our DNA and remain in our DNA forever (kind of like HIV does). Short threat about why this can't happen. (1/n)

I attach a graphic that illustrates the central genetic dogma. Generally, our human DNA is transcribed into RNA (red arrow), which is then translated into protein (green arrow). (2/n)

HIV is an RNA virus that goes against this dogma and is “reverse transcribed” into DNA in the cytoplasm of our cells after it enters our cells, using an enzyme called “reverse transcriptase” (straight yellow arrow). (3/n)

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Gertrud Rey PhD (Trudy)

@GertrudRey

11 Nov

There is a very good chance that whatever SARS-CoV-2 vaccine (or vaccines) we end up with will only prevent disease, but not infection. What does this mean? Short thread. (1/n)

Antibodies induced by vaccines or viruses can be neutralizing or non-neutralizing. Neutralizing antibodies don’t just bind viral antigens, but inactivate the virus and prevent infection of new cells. (2/n)

This means that the virus cannot replicate, leave the cell (or individual), and infect a new person. (3/n)

Read 7 tweets

Gertrud Rey PhD (Trudy)

@GertrudRey

7 Aug

If you have never read one of my articles before, I am begging you to read this one. It describes a strategy for how to end the pandemic and how YOU can help! A thread, also at virology blog. (1/n) virology.ws/2020/08/06/how…

As of today, SARS-CoV-2 has infected 18.7 million people and caused 700,000 deaths worldwide. (2/n)

The most realistic way to quickly curb the spread of the virus would require daily identification and isolation of individuals who are contagious, a process that is hampered by cumbersome sampling and testing methods with slow turnaround times. (3/n)

Read 30 tweets

Gertrud Rey PhD (Trudy)

@GertrudRey

30 Jul

Hydroxychloroquine (HCQ) Does not Work for Treating COVID-19. THE END.

***Warning! This post may be an emotional trigger for some! I’m just presenting the facts.***

Long thread. (1/n)

Sometime at the beginning of this never-ending year the president announced that HCQ was a “game-changer” for treating COVID-19. While I would be hesitant to embrace any drug as a game-changer without any real evidence, at that time, I did read a couple of studies... (2/n)

...done in Marseille, France, and felt cautiously optimistic about HCQ. When those studies came out, I posted about both of them and will summarize them briefly here. The first study showed that the drug can reduce viral load in a small number of COVID-19 patients. (3/n)

Read 27 tweets

Gertrud Rey PhD (Trudy)

@GertrudRey

4 Jun

Does a first infection with SARS-CoV-2 make a person immune to a second infection? This question is one of the prevailing issues in the current pandemic. A thread (also at virology blog). (1/n)

The relevant immune response is adaptive immunity, which initiates during a first exposure to a pathogen and protects from re-infection and disease upon a second exposure to the same pathogen. (2/n)

During that first exposure, T helper cells sense the presence of one or more proteins (i.e., antigens) on the surface of the invading pathogen and release a variety of signals that ultimately stimulate B cells to secrete antibodies to those antigens. (3/n)

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Gertrud Rey PhD (Trudy)

@GertrudRey

21 Apr

Remember the polio vaccine that was administered on a sugar cube? As it turns out, that vaccine may prevent against infection with SARS-CoV-2. The vaccine in question is the oral polio vaccine (OPV), a live-attenuated virus vaccine. A thread. (1/n)
microbe.tv/twiv/twiv-604/

It is a known fact that there are viruses that are persistently present in the population and that you can always isolate such viruses from healthy children. These viruses replicate “under the radar” and don’t cause disease. (2/n)

A couple of examples include several adenoviruses, rhinoviruses, etc. Back in the polio days when they were conducting clinical trials for OPV, they found that these other viruses were completely wiped out in children who had received OPV. (3/n)

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