Thread by @HiljaGebest

@c19d3k2 T- cells! 'The ability of complement to induce the expression of both VDR and the Vitamin D activating enzyme by T cells via CD46 binding is probably indicative of an autocrine or paracrine loop, which means that T cells activate VDR and respond to it.' news-medical.net/news/20200722/…

@c19d3k2 'Prior experimental studies have shown that vitamin D regulates CD4+ T-cell responses by promoting T helper 2 (Th2) cells and suppressing T helper 1 (Th1) cells, thereby limiting Th1-mediated inflammatory responses and tissue damage while enhancing Th2-med. anti-inflam.responses'

@c19d3k2 Recent studies have shown that CD4+T cells hv the capacity to convert inactive 25(OH)D to the active 1,25(OH)2D, which enhances vit D receptor expression and decreases vit D receptor proteasome degradation, both of which enable gene activation that results in CD4+ T-cell...

@c19d3k2 ...differentiation, T-cell antigen receptor signalling, and cytokine production "
Vitamin D up-regulates the vitamin D receptor by protecting it from proteasomal degradation in human CD4+ T cells
pubmed.ncbi.nlm.nih.gov/24792400/

@c19d3k2 academic.oup.com/jn/article/144……

Results: The absence of vitamin D signals significantly restricted (P ≤ 0.05) breadth of the antigen-specific CD8 T cell effector and memory repertoire.

@c19d3k2 A higher percentage of activated and proliferating CD8+ T cells in mild as compared to severe COVID-191,3. These findings hint at a protective role for SARS-CoV-2-specific CD8+ T cells." 
sciencedirect.com/science/articl…!

@c19d3k2 biorxiv.org/content/10.110…
Results emphasize the role of CD8+ T cells in antiviral immunity, and shed some more light on the nature of cross-reactivity with old human CoVs.

@c19d3k2 However, the proportion of the T cell response that is attributable to CD8+ T cells is increased in mild infections, consistent with findings in another study, which showed a higher percentage of activated and proliferating CD8+ T cells in mild as compared to severe COVID-191,3.

@c19d3k2 These findings hint at a protective role for SARS-CoV-2-specific CD8+ T cells, which is further supported by the greater proportion of clonally expanded CD8+ T cells in the infected lung in mild disease4.

nature.com/articles/s4159…

@c19d3k2 Last one: T-cells have the GREATEST NUMBER of Vit. D receptors of all immune cells. ncbi.nlm.nih.gov/pmc/articles/P…

@c19d3k2 Corrected link: nature.com/articles/s4159…

@c19d3k2 Sorry, correction here: meant CD8+ T-cells have the greatest number of Vit. D receptors (this is what happens when I tweet with kids jumping around!)