Should we screen for myeloma in high risk individuals?
For Blacks with one or more affected first-degree relatives, & all others with 2 or more affected first-degree relatives — Yes.
I’ve come to this conclusion after considering pros & cons. @nature nature.com/articles/d4158…
For Blacks with one or more affected first-degree relatives, & all others with 2 or more affected first-degree relatives — Yes.
I’ve come to this conclusion after considering pros & cons. @nature nature.com/articles/d4158…
If you are going to offer screening, I suggest only a one-time year at age 50 and older, or 10 years before diagnosis in first degree relative.
Test: SPEP, Serum IFE, and Serum FLC. We are not screening for MGUS, but for evidence suggestive of high risk SMM or MM.
Test: SPEP, Serum IFE, and Serum FLC. We are not screening for MGUS, but for evidence suggestive of high risk SMM or MM.
This recommendation affects a small number of people who are at high risk of developing SMM or MM. For all others, including general population, wait till results of iSTOP MM RCT, and other studies such as PROMISE. @sykristinsson @IreneGhobrial
In Blacks the risk of MM in younger age groups is 3-4 fold higher than Whites. Which is astounding. This risk increases further with an affected first degree relative. There is also disparity in access to health care following diagnosis.
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