Endomyocardial biopsy is typically performed via the right internal jugular using the Seldinger technique and fluoroscopic guidance. This is safely performed with a <1% risk of cardiac complication.
Fluoroscopic imaging showing endomyocardial biopsy of the RV septum by advancing a bioptome through the RA and tricuspid valve via the right internal jugular vein.
Fluoroscopic imaging showing endomyocardial biopsy of the RV septum by advancing a bioptome through the RA and tricuspid valve via a long sheath in the left internal jugular vein.
Video 3. Fluoroscopic imaging showing endomyocardial biopsy of the RV septum by advancing a bioptome through the RA and tricuspid valve via a long sheath in the right femoral vein.
The primary indications for endomyocardial biopsy are myocarditis, infiltrative cardiomyopathy, and surveillance of heart transplant rejection.
Recommendations for initial surveillance strategy for cardiac allograft rejection.
Recommendations for endomyocardial biopsy for unexplained acute cardiomyopathy include high-risk features that may suggest autoimmune myocarditis.
* Including giant-cell myocarditis, acute necrotizing eosinophilic myocarditis, and, if it impacts treatment, ICI myocarditis.
A simplified algorithm of endomyocardial biopsy-guided management of suspected myocarditis.
Simplified algorithm for the use of endomyocardial biopsy in the workup of infiltrative cardiomyopathies.
Cardiac biopsy for tumours may be reasonable if: 1) a non-biopsy diagnosis or non-cardiac-biopsy diagnosis is not possible, and 2) tissue diagnosis will alter management, and 3) an experienced operator is available to perform cardiac biopsy with a high chance of success.
Echocardiographic guidance is used to guide the biopsy of a very large right ventricular tumour.
So please consider endomyocardial biopsy in your diagnostic toolset, particularly for sick patients with myocarditis.
I hope you like this month's illustrative case. Follow and share if you enjoyed. More to come!
*Constrictive Pericarditis Tweetorial*
A 50-year-old male with a prior cardiac surgery with right heart failure. Exam shows a JVP of 15 cm and an estimated 20 kg of interstitial edema. What's abnormal? What are we looking for?
Echo shows normal biventricular size and systolic function, as well as ventricular septal motion abnormality from ventricular interdependence (not fully shown)