Deuterated DMT analogs?
New patent application by Small Pharma published today.
The “invention provides compositions and methods which enable a finely tuned single dose to maintain a patient in full dissociation from the external world, referred to herein as ‘DMT space.’”
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New patent application by Small Pharma published today.
The “invention provides compositions and methods which enable a finely tuned single dose to maintain a patient in full dissociation from the external world, referred to herein as ‘DMT space.’”
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In particular, the invention takes advantage of “the kinetic isotope effect” exhibited by deuterated DMT analogs “in order to modify, controllably, the pharmacokinetic profile of N,N-DMT, thereby permitting more flexible therapeutic application.”
pdfaiw.uspto.gov/.aiw?PageNum=0…
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pdfaiw.uspto.gov/.aiw?PageNum=0…
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“Deuterated” means that one or more hydrogen atoms in DMT are replaced by its heavier stable isotope deuterium. Because of the “kinetic isotope effect,” deuterated drugs may have significantly lower rates of metabolism and a longer half-life.
en.wikipedia.org/wiki/Deuterate…
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en.wikipedia.org/wiki/Deuterate…
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Deuterated DMT reported to have longer duration of action & shorter time to onset “apparently due to kinetic isotope effect which, in theory, makes it harder for the MAO enzyme to extract a deuterium (vs a hydrogen) thus inhibiting degradation by MAO”
ncbi.nlm.nih.gov/pmc/articles/P…
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ncbi.nlm.nih.gov/pmc/articles/P…
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The Small Pharma patent application compares in vitro intrinsic clearance and calculated half-life of DMT and six deuterated mixtures:
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Small Pharma’s currently pending claims cover:
–Compositions of DMT and deuterated DMT
–Methods of using them in therapy, and to treat OCD, depression, anxiety, substance abuse, and avolition disorder
–Methods of their synthesis
Application file: patentcenter.uspto.gov/#!/application…
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–Compositions of DMT and deuterated DMT
–Methods of using them in therapy, and to treat OCD, depression, anxiety, substance abuse, and avolition disorder
–Methods of their synthesis
Application file: patentcenter.uspto.gov/#!/application…
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Small Pharma includes a deuterated DMT candidate “SPL028” in preclinical investigation in their pipeline.
smallpharma.co.uk
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smallpharma.co.uk
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Small Pharma has announced that they will soon be listing on the TSXV exchange.
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https://twitter.com/smallpharma/status/1336319877938774016
At @PsilocybinAlpha we’ve so far created a psilocybin patent tracker and an MDMA patent tracker.
Should we do a DMT patent tracker next? Another compound? I’d love your thoughts on what would be useful or what you’d be curious to see. Thank you!
eof/
psilocybinalpha.com/data
Should we do a DMT patent tracker next? Another compound? I’d love your thoughts on what would be useful or what you’d be curious to see. Thank you!
eof/
psilocybinalpha.com/data
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