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Dr. Saskia Popescu Profile picture
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3 Feb, 4 tweets, 1 min read
Single Dose Vaccination in Healthcare Workers Previously Infected with SARS-CoV-2 medrxiv.org/content/10.110…
“At all time points tested, HCW with prior COVID-19 infection showed statistically significant higher antibody titers of binding and functional antibody compared to HCW without prior COVID-19 infection (p<.0001for each of the time points tested)."
“In times of vaccine shortage, and until correlates of protection are identified, our findings preliminarily suggest the following strategy as more evidence-based: a) a single dose of vaccine for patients already having had laboratory-confirmed COVID-19;.."
“and b) patients who have had laboratory-confirmed COVID-19 can be placed lower on the vaccination priority list.”

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More from @SaskiaPopescu

Dr. Saskia Popescu Profile picture
31 Jan
Sharing some insight as some one who’s been doing contact tracing for 10+ years: it’s about empathy and privacy. It’s also about having a general exposure definition to help gauge potential exposure. Is this perfect? Nope. No one has ever said contact tracing is perfect. (1/3)
It *is* an important public health tool. Sure, it would be great to have a super complex algorithm to help narrow if an exposure occurred, but that’s just not feasible (from both the PH standpoint AND that of the person being interviewed). Trust me, this isn’t an easy task. (2/3)
So while I get it’s easy to argue the 15 min/6ft rule (and trust me, we’re all for revisions), we need a place to start. It’s also pretty easy to judge it when you’re not actually doing it. Shout out to the teams of CTers - it’s hard work and we depend it. (3/3)
Read 4 tweets
Dr. Saskia Popescu Profile picture
23 Jan
During a convo yesterday I realized that we really haven’t invested much communication or awareness into what recovery means for others. There's still fear/stigma about being around some one after their iso period is done. This is a complicated topic, but one we should focus on🧵
For example, CDC does not recommend using testing to end isolation. Moreover, during the 90 days after infection, PCR testing is not recommended as a + indicates viral RNA shedding since we know reinfection during that time is exceedingly rare. cdc.gov/coronavirus/20…
Meaning, that during this 90 days, a + PCR in an asymptomatic individual could be startling at first, but really signifies persistent viral shedding, so that’s why re-testing isn’t encouraged. This is also why quarantine isn’t necessary during the 90 days if asymptomatic
Read 5 tweets
Dr. Saskia Popescu Profile picture
18 Jan
It’s fascinating to me to see people pull up tweets from Feb 2020 as a means to try and discredit people working in pandemic response. Our guidance evolves with the data and science, which is at a rapid pace during a pandemic of a novel disease. (1/3)
This is a tough part of our job, but one that means we’re improving continuously. PubHealth & healthcare response means leaning into these evolutions. Many of us speak to media/on social media in additional to our day jobs & it’s about using the best info we have at the time(2/3)
What I do find disparaging is when folks do this for nefarious goals..and ironic when it’s involving people who have self-identified as not engaging in anything related to ID/epi/pandemic response until spring 2020. We’re all tired, let’s try to be kind & respectful. (3/3)
Read 4 tweets
Dr. Saskia Popescu Profile picture
10 Jan
For everyone dumping on vaccine rollout- yes there have been a lot of issues & bottlenecking, but please know that a population-wide vaccine distribution is *tough*. Especially as hospitals and health dpts are doing the heavily lifting while under the weight of this surge.
We absolutely need to improve it and this has been another item in a long list of things the US has struggled with during COVID-19, but please note just how challenging and fractured a population-scale effort is.
Really, what this emphasizes is the need to provide more sustainable resources for these efforts (ahem, and public health in general). In short - critique and analyze the failures, but also acknowledge the Herculean effort this work requires.
Read 4 tweets
Dr. Saskia Popescu Profile picture
29 Dec 20
Breathtakingly honest and spot-on, @edyong209 brings 2020 full circle with this recap of our pandemic year and what 2021 might hold.
“People have been doing this for almost a year without backup.” Each COVID-19 peak has sapped more energy & morale, & afterward, fatigued HCWs have had to deal with a backlog of postponed surgeries, as well as new pts who have been sitting on their medical problems..”
Dr. @drjessigold -“In a crisis, you can say, ‘It makes sense that I’m anxious, sad, and not sleeping.’ But there’ll be a surge of problems once people finally get a chance to breathe and realize what the toll has been.”
Read 4 tweets
Dr. Saskia Popescu Profile picture
21 Sep 20
In terms of aerosols, droplet, & “airborne”- the best approach to communication I’ve found is that this requires enhanced respiratory protection in a healthcare setting. It’s not entirely airborne and it’s not entirely droplet, but rather something in the middle. (1/n)
We know this means different things for AGMP. For the public, I think it’s a good lesson in that the “6 ft” rule isn’t a hard rule in that there’s no magic force-field that prevents the virus from going further. Infection prevention involves multiple things simultaneously (2/n).
That Swiss cheese approach comes to mind - ventilation won’t do it all. Just like masks or distancing alone won’t. When we describe transmission it’s important to discuss these principles. Scicomm is critical & I’m hoping the CDC is working to explain these pieces better (3/n)/
Read 5 tweets

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