Feeling pessimistic about COVID & 2021?

Don't!

I'm not. Here's why

We'll likely have about 400M doses of Moderna/Pfizer by end of June

Enough to vaccinate 80% of adults

And that means a much better summer

Of course, we'll likely also have J&J, AZ, Novavax

Short thread
So by the time summer arrives, we'll have way more vaccines than people

Including for kids -- they'll likely get vaccinated over summer if not prior

That's supply. What about distribution?

Distribution problems were real in Dec/Jan

They are largely getting fixed

2/3
So I see no difficulties with us vaccinating 2-3M / day as we get into March/April. And vaccinated 150-200M by July 1

What could go wrong with scenario?

Pfizer/Moderna both suffer big production problems

AND

J&J, AZ, and Novavax don't deliver

Seems way, way unlikely

3/4
Next couple of months may be very tough (because of variants)

But by mid-spring, things will start looking better

And even by summer, some things won't be "normal" like large indoor gatherings

But backyard BBQs among vaccinated friends/family?

Safe and effective

End

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More from @ashishkjha

29 Jan
Heard of SARS-CoV2 variant from Japan?

No?

How about one from South Korea?

No?

Surely variants from New Zealand & Vietnam?

Of course not

Because these places haven't given rise to scary variants

But what places have.....has big implications for ending the pandemic

Thread
So let’s talk about where variants ARE coming from and under what circumstances

Variants arise when infections run wild

And selection pressures lead to dangerous mutations that can then thrive

Remember, every infection creates opportunities for “errors” – or mutations

2/6
Most mutations are meaningless

They will have no real clinical implications

But every once in a while, a set of mutations will lead the virus to become more contagious, more lethal, or improve its ability to escape our vaccines

So where are the variants coming from?

3/6
Read 9 tweets
24 Jan
Wondering whether the national COVID data is just a blip or something more substantive?

I think there is something good going on

Cases across the U.S. really are falling...and while its only been 2 weeks, it looks real

Here’s @FT graph that shows drop in new infections

Thread
You could look at this and say – hey, we’ve been in downturns before.

True

But last 2 downturns were smaller and both were largely data artifacts (under-reporting during Thanksgiving and Christmas)

This one is different

Is it a big deal? I think so

2/7
Let’s look at data: 7-day moving average from @covid19tracking

US case counts peaked 1/11/21 at new 244K cases daily

We are now down nearly 30% to 173K

Hospitalizations peaked at 131K, now down about 8% to 120K

We know deaths lag so no surprise, deaths are flat

3/7
Read 10 tweets
20 Jan
Among the Executive Orders that President Biden will sign today, I want to highlight one

It is critically important if we want to end this global pandemic

The EO that rescinds Trump's efforts to withdraw the US from @WHO

America is better off engaged with WHO

Thread
We live in a deeply interconnected -- indeed, interdependent world

That may be the single most important lesson of the pandemic

Support for U.S. leadership in global health has always been deeply bipartisan

Engaging WHO and global health more broadly has many benefits

2/6
Engaging in global health is consistent with our moral values

We are, at our best, a nation deeply committed to partnership and well-being of others

But U.S. engagement also benefits us

Bringing the pandemic to an end saves lives across the world, including those of Americans
Read 6 tweets
13 Jan
Looking at hospital data, there's something concerning happening in America's ICUs

There are 27,000 COVID patients in ICUs right now

On October 2, there were 7,000

And in order to accommodate the increase, hospitals are reducing access of non-COVID patients to ICU care

Thread
So let’s talk data, hospitalizations, & rationing

Think like a hospital leader facing a surge of COVID patients

What do you do?

First, as # of COVID patients starts to spike, you expand capacity

You convert ORs and anesthesia units to ICUs

You open up field hospitals

2/10
But what if surge continues?

At some point you can’t expand further – you're running out of staff

So you tell your doctors & nurses: Hey, ICU is full

Implicit message: slow down ICU admissions

As ICUs fill w COVID pts, ability of non-COVID pts to get ICU care diminishes

3/10
Read 14 tweets
12 Jan
We are in the worst days of the pandemic

How do we get through this?

So I’m teaming up w/ my friend, colleague, @MeganRanney to teach a new rapid-response course in Pandemic Problem Solving at @BrownUniversity

brown.edu/go/pandemicpro…

Quick thread on why & what to expect
Things are bad with this pandemic

Our institutions continue to confront major disruptions

The healthcare system is reeling

The vaccine rollout is slow

Businesses keep having to adjust their operations

Policymakers are struggling with how to devise good policy

2/n
But we have learned a lot already from how we navigated earlier waves of this pandemic

From sourcing PPE to our struggles to implement robust testing and tracing

Each week in this course, we will hear from leaders who will share their lessons learned

3/5
Read 6 tweets
11 Jan
Just spoke with a close colleague, thought I'd share his story

Have changed minor details to protect him

He's an ER Doc, working in a hot spot

Few days ago, early evening, vaccine team showed up with a bunch of extra doses of Moderna vaccine

Thread
They were looking for unvaccinated employees

Most employees there had been vaccinated. Rest were unwilling

Found several EMTs & patients who were excited to be vaccinated

But hospital policy was clear: non-employees aren't eligible

My friend, ER Doc, incensed, intervened

2/4
He tried to persuade vaccine team but they wouldn't over-ride hospital policy.

He called ER leadership. They wouldn't over-ride

Next, hospital leadership. They initially said no, claiming state mandate

He is persuasive and persistent....so they eventually relented

3/4
Read 5 tweets

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