"Any self-replicating agent released into..wild will be selected for enhanced transmission, underscoring..evolutionary risks inherent to..engineering and release of transmissible viruses"
"In addition to these troubling safety concerns, the development of transmissible vaccines will incur grave biosecurity risks due to the dual-use potential of the insights, tools and experience gained through such work."
"[T]ransmissible vaccine research will create an incentive to explore ways of engineering viral vectors to evade the immune response, as any pre-existing immunity to the vaccine vector will slow vaccine spread. "
"The history of biological weapons programmes[,and possibly of COVID-19,] suggests that such dual-use applications are not merely hypothetical"
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"'If the only information you're allowing to be weighed is provided by the very people who have everything to lose by revealing such evidence, that just doesn't come close to passing the sniff test,' said David A. Relman, a microbiologist at Stanford"
"Relman suggested that the WHO team should have sought complete, detailed records from the laboratories about their experiments and the raw genomic sequence data of their research going back a decade."
"'Just saying that they have really good safety protocols is not an answer in my view,' said Marc Lipsitch, a professor of epidemiology at Harvard’s T.H. Chan School of Public Health, who was not among the scientists on the trip. 'That alone does not put my mind at rest.'
"Signs..we live in a dying superpower are all around us. Officials..make illogical, chaotic decisions; and everything is much more complicated than it needs to be. Could no one have invented an app or..website that assigns people to..vaccination sites in order of priority?"
"Is it impossible for [a state] to..take direct control of the process, and order its National Guard to give out the vaccine at schools? How about letting the..oldest people get their shots first—as..orderly countries have done—before opening up the system to a million others?"
To Ashish Jha..of..Brown University..the insistence on offloading responsibility to..states looks less like a reasoned plan than a deliberate evasion tactic."
"'It’s very clear that the feds..didn’t know or care whether states were going to be able to do this or not. If states can’t do it, [they could] always blame them. And that has been the strategy from the very beginning.'"
"China’s experience has underscored the advice that many experts have suggested but few countries have followed: The more quickly you bring the pandemic under control, the more quickly the economy can recover"
“In many countries, debates have raged over the balance between protecting public health and keeping the economy running. In China, there is little debate. It did both.”
"The success has positioned China well, economically and diplomatically, to push back against the United States and others..It has also emboldened Mr. Xi, who has offered China’s experience as a model for others to follow."
"[T]here is another pathway, also plausible, that must be investigated. That is the possibility of a laboratory accident"
"Wuhan..is a..center of virus studies..with at least six..BSL-3 laboratories..some..very active in coronavirus research."
"To find out if there was a..lab..accident at..WIV..or another lab, investigators would want to..examine..lab notes, records of experiments and data, intra-laboratory communications.., as well as bat samples, viral strains and all sequences"
"One model that COVID-19 vaccine updates could follow is that of seasonal flu vaccines..Generally,..threshold for updating flu vaccines is similar in magnitude to..changes in neutralizing..responses that researchers have linked to the 501Y.V2 variant."
"Moderna..said..it expects to..rely on clinical trials involving 100s, rather than 1,000s, of participants to push forward with..vaccine against..variant. Foroohar expects that it will take..company..about 5 months to go from producing..new vaccine to submitting.. to regulators."
"Like Moderna, other coronavirus vaccine makers have said that they are looking into updating their vaccines. They include Johnson & Johnson of New Brunswick, New Jersey, which is developing a single-shot coronavirus vaccine."