So was Wakefield rightfully scrutinized and Drosten given a hall pass?
Many of the concerns raised about Wakefields qPCR are significant. But the one most cited (contamination) by Dr. Bustin was not.
He claimed Wakefield omitted an RT-Step.
Bustin is emulating this in 2020.
Wakefield is also nailed for Lack of an SOP.
Same story in the Drosten review.
The proper way to address DNA or RNA contamination is with DNases and RNases.
RT enzymes are active at RTemp and as the cycler ramps its temperature up to 95C.
#BustinBusted nature.com/articles/s4159…
@threadreaderapp unroll
Bustin continues to push for limited to No RT step in qPCR.
Precisely what he persecuted Wakefield for…and was paid handsomely for the testimony he has since contradicted.
@threadreaderapp unroll
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6 activities of Pfizer DNA
1)Nuclear Targeting Sequence (Dean)
2)Somatic Hypermutability element (Senigl)
3)Binds P53 (Drayman)
4)DAM/DCM methylation = cGAS-STING activation (Kwon et al)
5)Replication Competent without TAG
6)Prone to integrate (Strayer/Lim)
Finally, a cannabis adverse events database.
Long overdue to end all the receipt-free speculation.
Note the average age is 56y/o suggestive of polypharmacy and p450 collisions.
@Aelxberenson Gonna have to rename that book
People over 50 are on more blood thinners and other meds that rely on CYP2C9/19 and CYP3A4.
Note there are more Adverse events for products with high CBD/THC ratios related to Hallucinations, Dyspenia, Anxiety etc. That is likely a p450 collision as CBD isnt psychoactive in this way.
Lets look at the Adverse event frequency. 1-2 per 100,000 users.
mandated liability free vaccines = 1:800 from Dr. Joseph Fraiman
Note, over 80% of the SAEs with Cannabis the patient is using it for medical purposes also suggesting confounders and polypharmacy. pubmed.ncbi.nlm.nih.gov/36055877/
Flattered by the review.
An important pre-requisite is @jackmallers Madeira talk on time chains.
This does lead to a larger discussion around how the deflationary benefits of AI will flow into scarce and secure assets like BTC.
The reason BTC is growing faster than AI..
Is that it is actually an AI in disguise.
One has to widen their view of intelligence beyond anthropomorphic forms of intelligence and use a universal metric of intelligence as anything that creates value and perpetuates.
Under this view of intelligence being a value creation and perpetuation-
Bitcoin emerged to deliver things humans fail at… trust.
It quickly tapped into our energy grid to lower the cost of energy and salvage stranded energy.
It didn’t beat us at chess or make better political memes. It a filled an empty niche.
In doing so it captured 2 important