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Chise Profile picture
@sailorrooscout
Feb 10, 2021 • 8 tweets • 2 min read • Read on X
A very encouraging study done on our mRNA vaccines! Pfizer and Moderna vaccines provided strong immune responses against variant B.1.351 first identified in South Africa in those who recovered from previous SARS-CoV-2 infections with a SINGLE dose.
medrxiv.org/content/10.110…
Individuals who were previously infected with SARS-CoV-2 displayed weak neutralizing activity not only against the original strain but variant B.1.351 as well (4-8 months post infection; remember antibodies from natural infection eventually wane over time). However, immunization Image
with a single dose of either mRNA vaccine elicited a robust antibody response that boosted neutralizing titers against the original strain by approximately 1000-FOLD. More importantly, vaccination elicited a robust neutralizing antibody response against B.1.351, although
neutralizing titers were significantly (2-3) fold lower than they were to the original variant. This means a couple of things. Firstly, it is more than apparent our vaccines can boost pre-existing antibody titers in previously infected individuals even to such a point they can
neutralize highly divergent neutralization-resistant viral variants such as B.1.351. Think of it as utilizing your natural antibodies as a primer and one dose as your booster! Therefore, we could justify use of one dose in recovered individuals if necessary. Secondly, the immense
polyclonal protection our vaccines provide is just nothing short of monumental. The image above displays neutralizing activities in serum from recovered COVID-19 donors prior to and following a single immunization with Pfizer’s or Moderna’s mRNA vaccine against the origin strain
and variant B.1.351. So if you needed some good news today, here is some to get you started! Remember what I said in a previous post of mine, 2-3 fold reduction does NOT mean the vaccines are 2-3x less effective as you can see. I can link some of my threads & other studies too!
In short, one dose of Moderna’s or Pfizer’s mRNA vaccines provided sufficient protection against variant B.1.351 in individuals who have suffered from previous SARS-CoV-2 infections thus utilizing antibodies produced via natural infection as a primer and 1st dose as a booster.

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More from @sailorrooscout

Chise Profile picture
Oct 28, 2024
THIS IS HUGE! An HIV PrEP drug candidate in the form of a twice-yearly subcutaneous injection has been shown to reduce HIV infections by 96% in a SECOND late-stage Phase III trial. Lenacapavir was 99.9% effective at preventing HIV in MORE THAN 2,000 participants.🧵⬇️
Source:
• gilead.com/news/news-deta…Image
These results come from the PURPOSE 2 trial evaluating Gilead Sciences’ twice-yearly, subcutaneous Lenacapavir in individuals aged 16 years or older. Lenacapavir, which is a capsid inhibitor, is already approved by the FDA under the brand name Sunlenca for use alongside other
Read 13 tweets
Chise Profile picture
Oct 24, 2024
So, not COVID related BUT, this is REALLY exciting news. Phase I/II data shows Moderna’s Norovirus vaccine candidate mRNA-1403, has shown early signs of efficacy AND elicited robust serum HBGA-blocking antibody responses against ALL THREE NoV genotypes. Let’s talk about that!🧵⬇️
At IDWeek 2024, Moderna presented interim results from an ongoing Phase I/II, randomized, observer-blind, placebo-controlled, dose-ranging trial (NCT05992935) for mRNA-1403, a prophylactic vaccine candidate under investigation for norovirus (NoV) infections.
As one of the leading causes of acute gastroenteritis worldwide, NoV is associated with a substantial healthcare burden. Symptoms include vomiting and diarrhoea, which can be severely dehydrating, and the risk of severe outcomes from NoV is greatest in young children and older
Read 16 tweets
Chise Profile picture
Oct 21, 2024
THIS IS HUGE! Researchers at JHU have developed an experimental drug called RK-33, that in preclinical studies has shown promise in treating breast cancer with bone metastases. RK-33 eliminated the metastases AND prevented further cancer spread. Let’s talk about that!🧵⬇️
The research has been published in Cancer Letters. Yes, it is PEER-REVIEWED.
• sciencedirect.com/science/articl…Key Takeaways: •RK-33 targets DDX3, an RNA helicase elevated in cancer cells, to inhibit breast cancer bone metastasis. •In mouse models, RK-33 eliminated bone metastases and prevented further cancer spread without significant adverse effects. •The study suggests RK-33 as a promising treatment for breast cancer bone metastasis, urging further research into its broader applications.
In a new study led by Johns Hopkins Medicine, the drug RK-33 has demonstrated promise in treating breast cancer that has spread to the bone (breast cancer bone metastasis). RK-33 was previously shown to help treat other types of cancer and viral illnesses.
Read 14 tweets
Chise Profile picture
Oct 17, 2024
THIS IS HUGE! Researchers at Lancaster University have developed RI-AG03, a peptide inhibitor, that in preclinical studies PREVENTED the build-up of harmful Tau proteins in the brain, which are believed to be a key driver of Alzheimer’s disease. Let’s talk about that! 🧵⬇️
The research has been published in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association. Yes, it is PEER-REVIEWED.
•~ alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…What You Need to Know ⬇️ •Scientists have developed a new drug that targets two key regions of the tau protein, a major contributor to Alzheimer’s disease. •The drug, a peptide inhibitor called RI-AG03, successfully prevented the build-up of toxic tau proteins in both laboratory and fruit fly studies. •Although further research is necessary, including clinical trials in humans, this research contributes to the advancement of more effective therapies for neurodegenerative diseases. •There are two main “hotspots” on the tau protein, where fibril clumping occurs. In this new study, research...
Tau proteins are essential for maintaining the structure and function of neurons. However, in Alzheimer’s disease, these proteins malfunction and aggregate into long, twisted fibrils. As these fibrils build up, they form neurofibrillary tangles- masses of tangled tau proteins
Read 15 tweets
Chise Profile picture
Oct 9, 2024
THIS IS HUGE! Researchers at the University of Pennsylvania have developed a vaccine against the bacterium Clostridioides difficile (C.diff), that in preclinical studies, protected against succumbing from infection AND prevented recurring cases. Let’s talk about that! 🧵⬇️
The study has been published in Science. Yes, it is PEER-REVIEWED.
• science.org/doi/10.1126/sc…Model figure. (A) C. difficile toxins target the intestinal epithelium and cause severe pathology and gastrointestinal disease leading to morbidity and mortality. (B) When vaccinated mice are infected with C. difficile, anti-toxin IgG and IgA protect mice from disease and inclusion of PPEP-1 and CdeM as immunogens improves decolonization of toxigenic C. difficile from the gastrointestinal tract. Credit: Science (2024). DOI: 10.1126/science.adn4955
The bacterium Clostridioides difficile is named “difficult” for a reason. Originally, it was hard to grow in the lab, and, now, it’s the source of gut infections that are tough to treat. About half a million people in the U.S. contract C. diff every year, often from hospitals-
Read 15 tweets
Chise Profile picture
Oct 5, 2024
THIS IS HUGE! Scientists at the University of Oxford are developing the world's FIRST ovarian cancer vaccine that could potentially wipe the disease out. OvarianVax teaches the immune system to recognize and attack the earliest stages of ovarian cancer. Let’s talk about that!🧵⬇️
The hope is that individuals could receive the vaccine preventatively with the goal of eradicating the disease. Researchers have suggested it could work in a similar way to the human papillomavirus (HPV) vaccine, which is on track to stamp out cervical cancer.
Oxford researchers are designing OvarianVax, a vaccine which teaches the immune system to recognize and attack the earliest stages of ovarian cancer. The team will receive up to £600,000 for the study over the next three years to support lab research into the vaccine.
Read 12 tweets

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