Share this page!

Enter URL or ID to Unroll

You can paste full URL like: https://x.com/threadreaderapp/status/1644127596119195649
or just the ID like: 1644127596119195649

How to get URL link on X (Twitter) App

  1. On the Twitter thread, click on or icon on the bottom
  2. Click again on or Share Via icon
  3. Click on Copy Link to Tweet
  4. Paste it above and click "Unroll Thread"!
  5. More info at Twitter Help
Chise Profile picture
Chise
@sailorrooscout
Follow me here: https://t.co/P4dFsoKNkb
64 subscribers
Oct 28 • 13 tweets • 5 min read
THIS IS HUGE! An HIV PrEP drug candidate in the form of a twice-yearly subcutaneous injection has been shown to reduce HIV infections by 96% in a SECOND late-stage Phase III trial. Lenacapavir was 99.9% effective at preventing HIV in MORE THAN 2,000 participants.🧵⬇️ Source:
• gilead.com/news/news-deta…Image
Oct 24 • 16 tweets • 5 min read
So, not COVID related BUT, this is REALLY exciting news. Phase I/II data shows Moderna’s Norovirus vaccine candidate mRNA-1403, has shown early signs of efficacy AND elicited robust serum HBGA-blocking antibody responses against ALL THREE NoV genotypes. Let’s talk about that!🧵⬇️ At IDWeek 2024, Moderna presented interim results from an ongoing Phase I/II, randomized, observer-blind, placebo-controlled, dose-ranging trial (NCT05992935) for mRNA-1403, a prophylactic vaccine candidate under investigation for norovirus (NoV) infections.
Oct 21 • 14 tweets • 3 min read
THIS IS HUGE! Researchers at JHU have developed an experimental drug called RK-33, that in preclinical studies has shown promise in treating breast cancer with bone metastases. RK-33 eliminated the metastases AND prevented further cancer spread. Let’s talk about that!🧵⬇️ The research has been published in Cancer Letters. Yes, it is PEER-REVIEWED.
• sciencedirect.com/science/articl…Key Takeaways: •RK-33 targets DDX3, an RNA helicase elevated in cancer cells, to inhibit breast cancer bone metastasis. •In mouse models, RK-33 eliminated bone metastases and prevented further cancer spread without significant adverse effects. •The study suggests RK-33 as a promising treatment for breast cancer bone metastasis, urging further research into its broader applications.
Oct 17 • 15 tweets • 5 min read
THIS IS HUGE! Researchers at Lancaster University have developed RI-AG03, a peptide inhibitor, that in preclinical studies PREVENTED the build-up of harmful Tau proteins in the brain, which are believed to be a key driver of Alzheimer’s disease. Let’s talk about that! 🧵⬇️ The research has been published in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association. Yes, it is PEER-REVIEWED.
•~ alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…What You Need to Know ⬇️ •Scientists have developed a new drug that targets two key regions of the tau protein, a major contributor to Alzheimer’s disease. •The drug, a peptide inhibitor called RI-AG03, successfully prevented the build-up of toxic tau proteins in both laboratory and fruit fly studies. •Although further research is necessary, including clinical trials in humans, this research contributes to the advancement of more effective therapies for neurodegenerative diseases. •There are two main “hotspots” on the tau protein, where fibril clumping occurs. In this new study, research...
Oct 9 • 15 tweets • 4 min read
THIS IS HUGE! Researchers at the University of Pennsylvania have developed a vaccine against the bacterium Clostridioides difficile (C.diff), that in preclinical studies, protected against succumbing from infection AND prevented recurring cases. Let’s talk about that! 🧵⬇️ The study has been published in Science. Yes, it is PEER-REVIEWED.
• science.org/doi/10.1126/sc…Model figure. (A) C. difficile toxins target the intestinal epithelium and cause severe pathology and gastrointestinal disease leading to morbidity and mortality. (B) When vaccinated mice are infected with C. difficile, anti-toxin IgG and IgA protect mice from disease and inclusion of PPEP-1 and CdeM as immunogens improves decolonization of toxigenic C. difficile from the gastrointestinal tract. Credit: Science (2024). DOI: 10.1126/science.adn4955
Oct 5 • 12 tweets • 3 min read
THIS IS HUGE! Scientists at the University of Oxford are developing the world's FIRST ovarian cancer vaccine that could potentially wipe the disease out. OvarianVax teaches the immune system to recognize and attack the earliest stages of ovarian cancer. Let’s talk about that!🧵⬇️ The hope is that individuals could receive the vaccine preventatively with the goal of eradicating the disease. Researchers have suggested it could work in a similar way to the human papillomavirus (HPV) vaccine, which is on track to stamp out cervical cancer.
Oct 3 • 15 tweets • 5 min read
WOW! Researchers at ETH Zurich have effectively suppressed the growth of Glioblastoma, the most aggressive and deadly brain cancer, in BOTH ex vivo human tissue samples AND in preclinical trials with Vortioxetine- an FDA APPROVED serotonin modulator.

Let’s talk about that!🧵⬇️ The study has been published in Nature Medicine. Yes, it is PEER-REVIEWED.
• nature.com/articles/s4159…
Summary: Researchers have discovered that the antidepressant vortioxetine effectively combats glioblastoma, a deadly brain tumor, in lab tests and in mice. This drug, already FDA-approved, crosses the blood-brain barrier and could potentially improve treatment for glioblastoma patients when combined with standard therapy.
Sep 29 • 12 tweets • 4 min read
THIS IS HUGE! Researchers at Harvard Medical School have developed a nasal spray that in preclinical studies, offered NEARLY 100% protection from respiratory infections by COVID-19, influenza, viruses, AND pneumonia-causing bacteria. Let’s talk about that! 🧵⬇️ Researchers are calling their discovery Pathogen Capture and Neutralizing Spray (PCANS). The results are published in the journal Advanced Materials. Yes, it is PEER-REVIEWED.
• onlinelibrary.wiley.com/doi/10.1002/ad…
Image
Sep 23 • 15 tweets • 7 min read
All immunity is natural, because your immune system is natural.

It is acquired either through infection or vaccination. Infection has more side effects, many of which are very bad and one of which is death.

Naturally, I choose to acquire my immunity through vaccination. As originally stated by Dr. Rasmussen. I won’t tag her fully only because I don’t want to needlessly flood her mentions. I thought this was one of THE most influential statements regarding vaccination and immunity and that is why I wanted to share it today.
Sep 19 • 14 tweets • 5 min read
So, not COVID related BUT, this is REALLY exciting news. Interim data shows Moderna’s solid tumor vaccine candidate mRNA-4359, has shown early signs of efficacy AND activated key proteins to trigger an immune response for cancer killing cells.

Let’s talk about that! 🧵⬇️ Interim data from the Phase I dose escalation part of the mRNA cancer immunotherapy (mRNA-4359), has shown promise in patients with advanced solid cancers.

This investigational mRNA cancer immunotherapy is targeted for patients with lung cancer, melanoma and other solid tumors.
Sep 6 • 11 tweets • 3 min read
THIS IS HUGE! Researchers at The University of Texas at Austin have discovered and isolated a broadly neutralizing plasma antibody, known as SC27, which has been shown to neutralize ALL known variants of SARS-CoV-2.

Let’s talk about that! 🧵⬇️ The study has been published in Cell Reports Medicine.
• doi.org/10.1016/j.xcrm…
Graphical Abstract
Aug 24 • 14 tweets • 6 min read
Good Morning!

Here Is All You NEED TO KNOW About The Updated COVID-19 Shots Available NEXT WEEK!

Thank You For Reading! 🧵⬇️ Image 🎨: @JJENIAC

Recently, I have been getting a fair amount of questions regarding updated vaccines, timing, and current circulating SARS-CoV-2 strains so I figured an UPDATED thread would be helpful! IMAGE KEY POINTS •The Food and Drug Administration approved updated Covid vaccines from Pfizer and Moderna, putting the shots on track to reach most Americans in the coming days as the virus surges. •The jabs target a strain called KP.2, a descendant of the highly contagious omicron subvariant JN.1 that began circulating widely in the U.S. earlier this year. •The CDC recommended that everyone over 6 months old receive an updated Covid vaccine this year.
Aug 15 • 15 tweets • 9 min read
Reminder. We DO have a vaccine for Mpox. It’s the Smallpox vaccine, which successfully eradicated a disease that killed more than 300 million people since 1900. A massive global vaccination campaign put an end to that disease in 1977. Please stop the misinformation.🧵⬇️ IMPORTANT NOTE. JYNNEOS (Imvanex, IMVAMUNE) is a non-replicating vaccine for smallpox that CAN BE USED SAFELY in immunocompromised individuals and individuals with skin conditions such as eczema against Mpox.
•
• precisionvaccinations.com/vaccines/jynne…
cdc.gov/poxvirus/mpox/…


Image
Image
Image
Aug 1 • 15 tweets • 4 min read
THIS IS HUGE! A new nasal COVID-19 vaccine BLOCKS transmission of the virus, according to a recent study out of Washington University. This suggests vaccines delivered directly to the nose or mouth could play a critical role in containing the spread of respiratory infections.🧵⬇️ The study has been published in Science Advances.
•science.org/doi/10.1126/sc…
Jul 24 • 15 tweets • 4 min read
HOW COOL IS THIS? Researchers at the University of Illinois have developed a new dual-action antibiotic that could make bacterial resistance nearly impossible. Macrolones can work two different ways- either by interfering with protein production or corrupting DNA structure!🧵⬇️ Researchers have combined the bacteria-killing actions of two classes of antibiotics into one, demonstrating that their new antibiotic could make bacterial resistance (almost) an impossibility. The study has been published in Nature Chemical Biology.
•nature.com/articles/s4158…
Jul 22 • 15 tweets • 4 min read
THIS IS HUGE! Researchers at Northwestern Medicine and Brigham and Women’s Hospital have discovered a molecular defect that promotes the pathologic immune response in Lupus and show that reversing this defect may potentially reverse the disease!

Let’s talk about that! 🧵⬇️ The study has been published in Nature.
•

Lupus- officially known as systemic lupus erythematosus (SLE)- is an autoimmune disease that affects more than 1.5 million people in the U.S. Until this new study, the causes of this disease were unclear.nature.com/articles/s4158…
Jul 17 • 15 tweets • 6 min read
Good Morning!

Here Is All You NEED TO KNOW About The Updated COVID-19 Shots Planned For This Fall.

Thank You For Reading! 🧵⬇️ Image 🎨: @sherwiind

IT IS TIME FOR AN UPDATE THREAD. Many of you have had questions in regard to schedules and updated COVID-19 vaccines. I have some news for you!

Here is all you NEED TO KNOW About the New COVID-19 Vaccines Available THIS FALL.
Jun 27 • 15 tweets • 5 min read
THIS IS HUGE! Researchers at JHU have identified the Aplp1 protein, which facilitates the spread of harmful alpha-synuclein proteins in the brain as a novel therapeutic target for Parkinson’s disease AND a potential therapy using an EXISTING FDA-approved cancer drug.🧵⬇️ Source:
•
• link.springer.com/article/10.103…
hopkinsmedicine.org/news/newsroom/…

Summary: Researchers discovered a novel therapeutic target for Parkinson’s disease, the Aplp1 protein, which facilitates the spread of harmful alpha-synuclein proteins in the brain. Notably, an FDA-approved cancer drug targeting Lag3- a protein that interacts with Aplp1- has shown promise in blocking this spread in mouse models. This breakthrough research suggests the potential for repurposing existing cancer therapies for Parkinson’s disease and other neurodegenerative conditions.
Key Facts: •Aplp1 and Lag3 interaction is crucial for the spread of alpha-synuclein in the brain. •A FDA-approved cancer drug, nivolumab/relatlimab, targeting Lag3 shows potential in blocking this interaction. •This research offers new hope for the treatment of Parkinson’s and other neurodegenerative diseases.
Jun 21 • 14 tweets • 5 min read
THIS IS HUGE! For the FIRST time, an HIV PrEP drug candidate in the form of a twice-yearly subcutaneous shot has shown ZERO infections in a late-stage Phase III trial. Lenacapavir was 100% effective at preventing HIV in MORE THAN 2,000 participants.

Let’s talk about that!🧵⬇️ Source:
• gilead.com/news-and-press…
KEY POINTS •Gilead’s twice-yearly medicine to prevent HIV succeeded in a Phase 3 trial. •None of the roughly 2,000 women in the trial who received the lenacapavir shot contracted HIV. •Gilead needs to replicate the results in another Phase 3 trial before seeking FDA approval. The company expects to share more data later this year or early next year. •If the results are positive, Lenacapavir for PrEP could reach the market as soon as LATE 2025.
Jun 11 • 13 tweets • 3 min read
THIS IS HUGE! Researchers at the University of Illinois have developed a new antibiotic that reduced or eliminated drug-resistant bacterial infections (MORE THAN 130 multidrug-resistant bacterial strains, in fact) while sparing the gut microbiome!

Let’s talk about that!🧵⬇️ The findings were recently published in Nature.
•

The study looked at the development of an antibiotic that targets gram-negative bacteria without disturbing the gut microbiome.nature.com/articles/s4158…
Jun 7 • 15 tweets • 4 min read
THIS IS HUGE! A major trigger in inflammatory bowel disease (IBD) and related conditions has been identified, and existing drugs CAN stamp it out, in what scientists call a "massive step" in successfully treating these debilitating chronic conditions. Let’s talk about that! 🧵⬇️ Researchers at the Francis Crick Institute, in collaboration with University College London (UCL) and Imperial College London (ICL), have uncovered a problem gene enhancer that stimulates action along a specific biological pathway that causes IBD inflammation.