WSJ goes disingeneous in the extreme. The main cause of the Texas power outages were failure to winterize natural gas and coal fired power plants & isolation of the Texas power grid making it difficult to import power. Windmill icing was a distant third wsj.com/articles/a-dee…
@trvrb@LongDesertTrain@CT_Bergstrom Perhaps influenza (or any endemic virus) isn’t a good model. It depends on availability of susceptible hosts. A highly transmissible variant in one season would deplete the pool of available hosts in the next so endemic pathogens stabilize at moderate levels of transmission 1/
@trvrb@LongDesertTrain@CT_Bergstrom OTOH SARS-CoV-2 is in a transient phase and has yet to become endemic. ~All naive humans are susceptible so the immediate selective pressure is to maximize transmissibility
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@trvrb@LongDesertTrain@CT_Bergstrom Once SARS-CoV-2 has become endemic, maybe it will tend toward lower transmissibility, but we’re not there yet. Globally aren’t we still well under 50% seropositive? But likely there are subpopulations approaching herd immunity levels of infection/immunity
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Some push back on the notion that NIH spent hundreds of billions of dollars on basic research and therefore owns mRNA vaccine technology and has “march in” rights to dictate the use of pricing of this technology @RESachs@Dereklowe 1/
The fundamental contract underlying academic publication is that you publish your findings in return for recognition of priority, but once you have published others are free to use and build on your work. It’s practice established in the time of Newton and honored ever since
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No question mRNA vaccines draw on much basic molecular biology and would not have be possible without the work of Avery, MacLeod, Hershey, Chase, Nirenberg, Jacob & Monod, Sanger, Mullis, and many others. These scientists have received many well justified accolades and honors
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Despite the catchy headline, the mandate of the CDC is far broader than pandemics, and the problems at the CDC precede COVID-19. But yes, the response to the COVID-19 pandemic was deeply flawed and systemic 1/ nytimes.com/2020/06/03/us/…
Vaccination is a key public health responsibility, and the US does well on influenza vaccination of the elderly, but we are middle of the pack on childhood vaccination rates 2/ data.oecd.org/healthcare/inf…
The Obesity Epidemic has been a disaster. Remember back when Surgeon General Luther Terry took on big tobacco and won? Big food not so much 3/ thelancet.com/journals/lanpu…
Let’s talk about Fall Semester. Colleges and universities have to make some big decisions soon 1/
And it won’t affect just students. For example, the University of Michigan #GoBlue has 46,000 students but it also has 25,000 faculty and staff. While students may be mostly young, many faculty and staff are in vulnerable age groups 2/ cupahr.org/wp-content/upl…
There’s also real meaning to “university community”, schools are densely linked social networks with multiple paths linking students, e.g. classes. Eliminating large classes can reduce but not eliminate the potential for epidemic spread 3/ osf.io/6kuet/
Epidemiologists and economists say we need millions if not tens of millions of tests/day to convince people it's safe to re-open the economy, e.g. this Harvard study estimates we'll need 20 millions tests per day ethics.harvard.edu/Covid-Roadmap
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Nobel Laurette Paul Romer’s @paulmromer simulations say we need to test everyone in the US every two weeks, or about 25 million tests per day paulromer.net/covid-sim-part…
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The most sensitive and specific tests for COVID-19 use quantitative RTPCR. We have about 1,000 instruments each able to run about 1,000 RTPCR tests per day for a national capacity of about a million tests per day.
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The explosive growth seen in early outbreaks within community may be a result of highly exposed individuals rapidly spreading to their many connections. As we re-open we may see slower spread because many of the highly connected people are now immune 1/
But it’s important note that this phenomenon only applies after the virus has been spreading in the community for a while. As the people of Albany Georgia learned, it only takes one individual in the wrong setting to trigger a large outbreak 2/
Also we talk to much about testing as binary “+” or “-“, but positive at Ct 16 on an RTPCR is a millions times more virus than positive at Ct 36. Bad things happened when a highly contagious person shedding lots of virus gets into a setting where many people can be exposed 3/