Vaccines are preventives, not cures.
The purpose of vaccination is to bring the severity level down to that of a benign virus. That’s how this works. Our best protection is to keep cases low and get people vaccinated. To expect eradication of this virus right now is unrealistic.
With this said, the more people vaccinated, the more restrictions should start to be lifted. Why? We are already starting to see evidence these vaccines do prevent transmission the more data comes out; it would be extremely ignorant to suggest otherwise or disregard it.
Eradicating this virus right now from the world is a lot like trying to dig a tunnel to the center of the Earth using only a plastic spoon. It’s unrealistic. Some forget or simply don’t care (totally different virus) but Polio was endemic before it was 100% declared eradicated.
BUT, and hear me clearly and don’t even attempt to twist my words on this one: failure to eradicate this virus DOES NOT mean that death, illness or social isolation will continue on the scales we have seen so far. If you suggest otherwise you are either 1. Blatantly disregarding
the physical properties of viruses and the mechanism of vaccines and how they work or 2. Trying to push an agenda. You choose. I think a lot of people tend to forget this or just not want to acknowledge it at all. In addition, let’s not forget when we look at similar viruses that
Influenza and the four human coronaviruses (229E, NL63, OC43, and HKU1) that cause common colds are also endemic. But guess what? A combination of annual vaccines and acquired immunity has allowed all of us as a society with the means to tolerate the seasonal illness they bring
without requiring lockdowns, masks and social distancing for extended periods of time. Do I think it’s a good hygienic practice for those who are sick to wear masks out in public? Absolutely. Do I believe everyone has to until we are down to 0 cases? No, because I know how this
works and I understand how viruses work and how this has gone throughout history when we look back on past pandemics and epidemics. Our future will depend heavily on the type of immunity people acquire through infection or vaccination and how this virus evolves. But, if you have
read my other thread on selective pressure, which I highly recommend you do, you will see that keeping cases low and subsequently outrunning this virus by upping mass vaccination efforts and knocking out transmission (which again, the heavy use of masks was due to the unknown
ability of these vaccines to prevent transmission at the time) is the way to go. The more we see they prevent transmission, the more they are like any other vaccine. This Coronavirus is no different than any others in a biological sense, only different in the way we treat it.
Some may not like what I have to say and that’s okay. Zero COVID is unrealistic. It has not been expected immediately of any other virus prior to it. It disregards properties of viruses, the purpose of these vaccines, and teeters dangerously on the edge of antivaxx propaganda.
Also goodness cause I’m already seeing this. Don’t take it out of context. Yes, until there is more data on the fact these continue to prevent transmission, still wear your mask. What I refer to above is more so when the majority of a population is vaccinated and protected.
I think it’s a good day to bring this up again, as we are witnessing exactly how well these vaccines do work. Lastly, if you are confused as to why it’s optimal to keep transmission down (with NPIs AND vaccines) please see this thread.

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More from @sailorrooscout

16 Apr
Please keep in mind variant B.1.167 out of India is still considered a variant of interest, not a variant of concern. B.1.167 lineage isolates are actually common in India and while it carries mutations E484Q and L452R, it does not carry any deletion mutations we see in current
variants of concern. Lastly, this variant was present in India last year, and while media highlights the presence of it in the UK as recent, it’s first occurrence in the UK dates back to February 22nd. The claims that it bypasses T-cell immunity are NOT currently substantiated.
The most important thing as always is to get vaccinated and control its spread. Let’s stay focused. Current variants of concern are: B.1.351, P.1, B.1.1.7, and B.1.427/B.1.429.
Read 4 tweets
14 Apr
Preclinical data shows Moderna’s variant-specific booster vaccine candidates (mRNA-1273.351 and mRNA-1273.211) increase neutralizing titers against SARS-CoV-2 variants of concern. The data is absolutely stunning! Preprint can be found here:
biorxiv.org/content/10.110…
mRNA-1273.351 encodes for the S protein found in the B.1.351 lineage and mRNA-1273.211 comprising a 1:1 mix of mRNA-1273 and mRNA-1273.351. Both vaccines were evaluated as a 2-dose primary series in mice.
mRNA-1273.351 was also evaluated as a booster dose in animals previously vaccinated with 2-doses of mRNA-1273. The results demonstrate that a primary vaccination series of mRNA-1273.351 was effective at increasing neutralizing antibody titers against the B.1.351 lineage, while
Read 5 tweets
13 Apr
Please be aware that out of 6.8M+ doses of the J&J vaccine that have been administered in the U.S., 6 cases of a rare & severe type of blood clot in individuals after receiving the vaccine have been reported. Right now, these adverse events appear to be extremely rare.
With this said, in the U.S., we have mRNA (Moderna & Pfizer) vaccines available so please do not let this deter you from getting vaccinated in the meantime. All 6 cases occurred among women between the ages of 18 and 48, and symptoms occurred 6 to 13 days after vaccination.
I want everyone to put this in perspective and try to process this rationally. 6 cases out of 6.8M+ doses administered (0.00000088). They’re looking into this out of an abundance of caution. You are MORE likely to suffer from blood clots from being infected with SARS-CoV-2.
Read 6 tweets
10 Apr
Wanted to clear this up. First, please remember that vaccines are preventives and NOT cures. One can still contract the virus once vaccinated and as long as it prevents them from facing severe disease and worse, it is still doing what it is supposed to.
timesofisrael.com/real-world-isr…
Secondly, what is important to know about this study is that most infections were from B.1.1.7, with only 8 cases being B.1.351. After two doses, extremely high effectiveness against B.1.1.7 took effect. While they observed reduced effectiveness against B.1.351, they also saw it
did not spread in Israel. In other words, B.1.1.7 is keeping B.1.351 “in check” which is what a lot of scientists predicted months ago when these variants came onto the scene. This is a good thing. Why? We know the vaccines are HIGHLY effective against B.1.1.7
Read 6 tweets
8 Apr
Encouraging studies! 🧵
An analysis of cross-reactive viral binding and neutralization of emerging SARS-CoV-2 variants shows Novavax’s and Moderna’s vaccines elicit immune responses that are effective against variants B.1.429 (CA) and B.1.351 (S. Africa).
nejm.org/doi/full/10.10…
Patients previously infected with SARS-CoV-2 received Pfizer’s vaccine. Before vaccination, they had neutralizing activity against variants B.1.1.7 & P.1 but not B.1.351. AFTER one dose, neutralizing activity against ALL variants increased substantially!
nejm.org/doi/full/10.10…
Convalescent serum from those who recovered from an infection with SARS-CoV-2 variant B.1.351 showed potent neutralization of D614G (original), as well as variants B.1.351 (S. Africa) AND P.1 (Brazil). Booster vaccines may just seal the deal if needed!
nejm.org/doi/full/10.10…
Read 9 tweets
5 Apr
We know individuals who recover from SARS-CoV-2 infections develop effective T-cell immunity. A new study in Nature finds individuals are able to gain T-cell memory in the absence of a detectable infection simply from exposure!
nature.com/articles/s4146…
Here researchers reported virus-specific CD4+ and CD8+ T-cell memory in recovered COVID-19 patients and close contacts. Data showed that the memory CD4+ and CD8+ T cells of 94.44% and 83.33%, respectively, of the COVID-19 patients successfully underwent expansion.
Their results indicated that most of the recovered COVID-19 patients had developed effective T-cell memory pools against SARS-CoV-2 and their close contacts to a lesser degree. The proliferation capacity, size and quality of T-cell responses in close contacts were also readily
Read 6 tweets

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