Vaccines are preventives, not cures.
The purpose of vaccination is to bring the severity level down to that of a benign virus. That’s how this works. Our best protection is to keep cases low and get people vaccinated. To expect eradication of this virus right now is unrealistic.
With this said, the more people vaccinated, the more restrictions should start to be lifted. Why? We are already starting to see evidence these vaccines do prevent transmission the more data comes out; it would be extremely ignorant to suggest otherwise or disregard it.
Eradicating this virus right now from the world is a lot like trying to dig a tunnel to the center of the Earth using only a plastic spoon. It’s unrealistic. Some forget or simply don’t care (totally different virus) but Polio was endemic before it was 100% declared eradicated.
BUT, and hear me clearly and don’t even attempt to twist my words on this one: failure to eradicate this virus DOES NOT mean that death, illness or social isolation will continue on the scales we have seen so far. If you suggest otherwise you are either 1. Blatantly disregarding
the physical properties of viruses and the mechanism of vaccines and how they work or 2. Trying to push an agenda. You choose. I think a lot of people tend to forget this or just not want to acknowledge it at all. In addition, let’s not forget when we look at similar viruses that
Influenza and the four human coronaviruses (229E, NL63, OC43, and HKU1) that cause common colds are also endemic. But guess what? A combination of annual vaccines and acquired immunity has allowed all of us as a society with the means to tolerate the seasonal illness they bring
without requiring lockdowns, masks and social distancing for extended periods of time. Do I think it’s a good hygienic practice for those who are sick to wear masks out in public? Absolutely. Do I believe everyone has to until we are down to 0 cases? No, because I know how this
works and I understand how viruses work and how this has gone throughout history when we look back on past pandemics and epidemics. Our future will depend heavily on the type of immunity people acquire through infection or vaccination and how this virus evolves. But, if you have
read my other thread on selective pressure, which I highly recommend you do, you will see that keeping cases low and subsequently outrunning this virus by upping mass vaccination efforts and knocking out transmission (which again, the heavy use of masks was due to the unknown
ability of these vaccines to prevent transmission at the time) is the way to go. The more we see they prevent transmission, the more they are like any other vaccine. This Coronavirus is no different than any others in a biological sense, only different in the way we treat it.
Some may not like what I have to say and that’s okay. Zero COVID is unrealistic. It has not been expected immediately of any other virus prior to it. It disregards properties of viruses, the purpose of these vaccines, and teeters dangerously on the edge of antivaxx propaganda.
Also goodness cause I’m already seeing this. Don’t take it out of context. Yes, until there is more data on the fact these continue to prevent transmission, still wear your mask. What I refer to above is more so when the majority of a population is vaccinated and protected.
I think it’s a good day to bring this up again, as we are witnessing exactly how well these vaccines do work. Lastly, if you are confused as to why it’s optimal to keep transmission down (with NPIs AND vaccines) please see this thread.
THIS IS HUGE! An HIV PrEP drug candidate in the form of a twice-yearly subcutaneous injection has been shown to reduce HIV infections by 96% in a SECOND late-stage Phase III trial. Lenacapavir was 99.9% effective at preventing HIV in MORE THAN 2,000 participants.🧵⬇️
These results come from the PURPOSE 2 trial evaluating Gilead Sciences’ twice-yearly, subcutaneous Lenacapavir in individuals aged 16 years or older. Lenacapavir, which is a capsid inhibitor, is already approved by the FDA under the brand name Sunlenca for use alongside other
So, not COVID related BUT, this is REALLY exciting news. Phase I/II data shows Moderna’s Norovirus vaccine candidate mRNA-1403, has shown early signs of efficacy AND elicited robust serum HBGA-blocking antibody responses against ALL THREE NoV genotypes. Let’s talk about that!🧵⬇️
At IDWeek 2024, Moderna presented interim results from an ongoing Phase I/II, randomized, observer-blind, placebo-controlled, dose-ranging trial (NCT05992935) for mRNA-1403, a prophylactic vaccine candidate under investigation for norovirus (NoV) infections.
As one of the leading causes of acute gastroenteritis worldwide, NoV is associated with a substantial healthcare burden. Symptoms include vomiting and diarrhoea, which can be severely dehydrating, and the risk of severe outcomes from NoV is greatest in young children and older
THIS IS HUGE! Researchers at JHU have developed an experimental drug called RK-33, that in preclinical studies has shown promise in treating breast cancer with bone metastases. RK-33 eliminated the metastases AND prevented further cancer spread. Let’s talk about that!🧵⬇️
In a new study led by Johns Hopkins Medicine, the drug RK-33 has demonstrated promise in treating breast cancer that has spread to the bone (breast cancer bone metastasis). RK-33 was previously shown to help treat other types of cancer and viral illnesses.
THIS IS HUGE! Researchers at Lancaster University have developed RI-AG03, a peptide inhibitor, that in preclinical studies PREVENTED the build-up of harmful Tau proteins in the brain, which are believed to be a key driver of Alzheimer’s disease. Let’s talk about that! 🧵⬇️
Tau proteins are essential for maintaining the structure and function of neurons. However, in Alzheimer’s disease, these proteins malfunction and aggregate into long, twisted fibrils. As these fibrils build up, they form neurofibrillary tangles- masses of tangled tau proteins
THIS IS HUGE! Researchers at the University of Pennsylvania have developed a vaccine against the bacterium Clostridioides difficile (C.diff), that in preclinical studies, protected against succumbing from infection AND prevented recurring cases. Let’s talk about that! 🧵⬇️
The bacterium Clostridioides difficile is named “difficult” for a reason. Originally, it was hard to grow in the lab, and, now, it’s the source of gut infections that are tough to treat. About half a million people in the U.S. contract C. diff every year, often from hospitals-
THIS IS HUGE! Scientists at the University of Oxford are developing the world's FIRST ovarian cancer vaccine that could potentially wipe the disease out. OvarianVax teaches the immune system to recognize and attack the earliest stages of ovarian cancer. Let’s talk about that!🧵⬇️
The hope is that individuals could receive the vaccine preventatively with the goal of eradicating the disease. Researchers have suggested it could work in a similar way to the human papillomavirus (HPV) vaccine, which is on track to stamp out cervical cancer.
Oxford researchers are designing OvarianVax, a vaccine which teaches the immune system to recognize and attack the earliest stages of ovarian cancer. The team will receive up to £600,000 for the study over the next three years to support lab research into the vaccine.