Thread by @MRCNIHRTMRP

PANDA is an open access & multidisciplinary practical educational resource for those who are keen to learn more about adaptive designs. The aim is to help them make baby steps & bridge the existing practical knowledge gap. See demo version here: panda.demo2.epigenesys.org.uk

Our target audience includes statisticians, clinicians, proposal developers, trial managers, data managers, health economists, and reviewers of grant applications. See the scope of what is covered by the PANDA toolkit: panda.demo2.epigenesys.org.uk/about_panda

The toolkit is structured to enable users to easily find content that is relevant to them. We take PANDA users through a learning journey from planning & design to reporting covering general considerations & specific types of adaptive designs.

Detailed case studies are presented focusing on practical aspects so that users can reproduce what was done & learn from them. We also illustrate the design, monitoring, & analysis of trials using specific adaptive designs including snippets on statistical code. For example:

We want PANDA to be a repository of practical resources such as available statistical software, guidance, tutorial papers, easy-to-read books with case studies, and other related online learning resources.

This is a community resource so we would like researchers to contribute by sharing their practical experiences of running adaptive trials including positive & negative experiences & lessons learned. Please feel free to contact us on related issues via [e-mail]

Finally, #shoutout to the PANDA team for this work: @mdimairo @thomas_jaki @DrGWheeler @Flight_LG @MikeBradburn2 & others who’re not on Twitter: panda.demo2.epigenesys.org.uk/the_team

And @NIHRresearch for the funding!