For Junior Doctors

Let us have a brainstorming session shall we?
Real patient with real management from me 😉

Scenario

40 years old
- obese
- came with back carbuncle
- operated with no complication

This is his cxr prior to admission Image
Day 4 of admission

- Having shortness of breath
- suddenly desaturated, needing oxygen support
- Hypotensive needing inotropic support
- no fever, cough

- lungs: clear
- S1S2 no murmur

Blood investigation
- no leucocytosis
This is his repeated chest xray on day 4 of admission

What you guys can see from this chest xray? Image
Yes , oligemic lung field. If you guys cant see the changes, please refer to previous cxr.

it is also called Westermark sign Image
Westermark sign is a chest x-ray finding of oligaemia (clarified area) distal to a large vessel that is occluded by a pulmonary embolus.
The focal area of increased translucency due to oligaemia is caused by impaired vascularisation of the lung due to primary mechanical obstruction or reflex vasoconstriction
So how do we confirm our diagnosis?

Yes CTPA was done and it showed massive pulmonary embolism. Patient is diagnosed to have a provoke pulmonary embolism.
Pulmonary embolism (PE) is a life-threatening condition resulting from dislodged thrombi occluding the pulmonary vasculature; right heart failure and cardiac arrest may ensue if not aggressively treated.
Clinical probability, assessed by a validated prediction rule and clinical judgement, is the basis for all diagnostic strategies for PE. Computed tomographic pulmonary angiography is the definitive diagnostic investigation.
Management?

First you need to classify whether the patient is hemodynamically stable or unstable

hemodynamically unstable
- Thrombolysis or thrombectomy

hemodynamically stable
- Anticoagulant

Easy right?
That is all from me tonight

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More from @DIskandarmirza

28 Feb
For Junior Doctors and Pharmacists

Topic: The Pathophysiology of Thyroid Hormones and Anti thyroid Medications

Remember guys, to master the topic you first need to understand the pathophysiology of
-Thyroid hormones production
-Anti thyroid medications

Follow this thread Image
Thyroid synthesis

1)Iodine transport

Iodide (I-) from the blood is actively transported into the follicular lumen Image
2)Thyroglobulin synthesis

Thyroglobulin is a protein that contains large numbers of tyrosine amino acids that go on to become individual thyroid hormone molecules. Thyroglobulin is synthesized within the follicular epithelial cell and secreted into the follicular lumen. Image
Read 15 tweets
27 Feb
Anda tahu apa itu penyakit Tetanus? (kancing gigi)

Bagaimana ianya berlaku?
Bangaimana untuk megelak dari mendapat tetanus?

Sila follow bebenang ini Image
Pengenalan

Penyakit tetanus adalah penyakit yang serius berpunca daripada toksin bakteria yang merosakkan sistem saraf dan menyebabkan kekejangan otot yang menyakitkan terutama di bahagian rahang dan otot leher. Image
Tetanus boleh mengganggu sistem pernafasan anda dan membuat anda susah untuk bernafas.

Sakit Tetanus adalah sangat jarang berlaku di Malaysia disebabkan oleh program immunisasi yang diberikan oleh kerajaan Malaysia. Image
Read 12 tweets
21 Feb
For Junior Doctors

Do you really know how diabetic medications mechanism of action?

It is really important so that you know what to explain to the patient and thus making them more compliant towards their diabetic medications.

Follow this thread
First you guys need to understand how patient developed diabetes mellitus.

Refer to diagram below

Diabetes mellitus pathophysiology is involving multi-organ involvement

And each diabetic medications will inhibit part of the organs involved.
Now you understand right how hyperglycemia happened in diabetic patient? it took me all night to do all this diagram 😆

now we go to each medications and remember this is simplified version as i only can type few words in twitter
Read 14 tweets
20 Feb
Anda ada atrial fibrillation?

Anda faham apa itu atrial fibrillation?
Anda faham mengapa anda perlu makan ubat cair darah?

Follow bebenang ini

@MedTweetMYHQ
#MedTweetMY
Atria fibrillation adalah masalah rentak jantung yang tidak sekata dan ianya boleh menyebabkan rasa jantung berdenyut laju, berdebar dan rasa jantung turun-naik dengan cepat.
Simptom Atrial flutter adalah

- Jantung rasa berdebar secara tiba-tiba
- Cepat rasa penat
- Sesak nafas
- Rasa hendak pitam
- atau sesetengah pesakit tidak mempunyai apa- apa simptom
Read 7 tweets
20 Feb
For junior doctors

How to Decide on anticoagulant for Atrial Fibrillation

Follow this steps
You need to calculate the CHA2DS-VASc score first

This is how you calculate a CHA2DS-VASc score
If CHAD2DS-VASc score=

1(male) or 2 (female) = OAC should be considered (Class iia)
>2 (male) or >3 (female) + OAC is recomended (Class 1A)

OAC : oral anticoagulant
Do you understand about the class of recommendation?

Just a little bit about it, because it is important for you guys to know it.

Class 1 means: it is recommended
class II: conflicting evidence or divergent opinion about the usefulness of the given treatment
Read 7 tweets
18 Feb
For Junior Doctors

Have you guys heard of Chiladaiti syndrome?

I'm sharing my case from HTAN, Pilah and how I managed this case.

@MedTweetMYHQ
#MedTweetMY Image
62 y.o guy with
- PTB on intensive phase day 40
- dm
- hypertension
- dyslipidemia

Came with right hypochondriac and epigastric tenderness
- associated with nausea and vomiting
- no fever
- reduced oral intake
- able to pass flatus and BO
- no aggravating or relieving factor
Cxr
- showed consolidation over right upper zone
- bowel shadow below right diaphragm

Patient was treated for chiladaiti syndrome
- ryles tube free flow
- keep nil by mouth
- lactulose 15 mls tds
- IVD for hydration Image
Read 9 tweets

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