Fantastic summary @profshanecrotty of J&J vaccine.
One important correction (I need to write a full thread about).
NONE of the vaccines are 100% protective effective against hospitalizations & death. We know this from vaccine rollout (DOI: 10.1056/NEJMoa2101765).
(cont)
One important correction (I need to write a full thread about).
NONE of the vaccines are 100% protective effective against hospitalizations & death. We know this from vaccine rollout (DOI: 10.1056/NEJMoa2101765).
(cont)
https://twitter.com/profshanecrotty/status/1365442991276527619
None of the trials are big enough or long enough to accurately measure efficacy against death or even hospitalizations. In huge J&J trial hospitalization was 16 vs 0 which gives a CI of 74%-100%. 16 events is simply too small to say protection is 100% & we know it's not.
We need to be careful about how we describe these vaccines b/c otherwise the public will wonder: if all vaccines have 100% protection against hospitalization & deaths, then why are some of the 50M vaccinated people getting hospitalized & dying of COVID-19?
Let's keep the honest very positive descriptions of the vaccines going (they are fantastic!) but let's not oversell them or set people up to think they've been lied to when protection isn't 100%. It's not. But it's very very high & that's wonderful.
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