New preprint led by a very talented ID physician-scientist in my group @eeeejjjaaaa. He studied the effect of SARS-CoV-2 plasma viremia in a cohort of patients presenting to the Emergency Department w/ respiratory dysfxn. Huge thanks to @MGoldbergLab @arnavmehta3 + others 1/n
https://twitter.com/eeeejjjaaaa/status/1365728473445195778
While COVID is generally thought to be a pulmonary disease, 36% of participants had detectable SARS-CoV-2 RNA in plasma at the time of ED presentation. Viremia was associated with elevated inflammatory markers, lower lymphocyte counts, and signs of organ dysfunction 2/n 
Levels of SARS-CoV-2 viremia at the time of ED visit predicted maximal disease severity during the course of the hospitalization with an adjusted OR of 10.6 for mechanical ventilation or death at 28 days. 3/n
Viremia was also associated with altered proteomic pathways involved in cytokine production and tissue damage to the lungs, GI tract, heart and vascular system. 4/n
SARS-CoV-2 plasma viremia likely originates from the lungs, but this data adds to the evidence that the virus can disseminate into the blood stream and to other organs. The results also point to cellular pathways that may mediate the poor outcomes associated with viremia 5/5
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