The medical journal Alimentary Pharmacology & Therapeutics published my letter to the editor today exploring some hypotheses on why high-dose thiamine may reduce fatigue in patients with diverse immunological and neurological conditions. onlinelibrary.wiley.com/doi/full/10.11….
My letter comments on a groundbreaking RCT which found that high-dose thiamine reduced fatigue in patients with quiescent IBD. onlinelibrary.wiley.com/doi/abs/10.111…. The authors' response to my letter can be found here: onlinelibrary.wiley.com/doi/10.1111/ap…
My hypotheses focus on the role of high-dose thiamine in inhibiting carbonic anhydrase isoenzymes. pubmed.ncbi.nlm.nih.gov/22145674/ . At present this has been shown only in vitro, so studies in humans are needed to confirm.
I hypothesize that the benefits accrue through one or more of four potential pathways: (a) by reducing intracranial hypertension and/or ventral brainstem compression; (b) by increasing blood flow to the brain . . .
(c) by facilitating aerobic cellular respiration and lactate clearance through the Bohr effect; or by (d) tamping down the pro-inflammatory Th-17 pathway, again through the Bohr effect, possibly modulated by reductions in hypoxia-inducible factor 1.
I elaborate on my hypotheses on why thiamine may reduced fatigue here: medium.com/eds-perspectiv…
In this post, I explore the possibility that high-dose thiamine may reduce post-exertional malaise and improve visual and mental acuity in people with ME-CFS and Ehlers-Danlos Syndrome. medium.com/eds-perspectiv…
At this point, these are just hypotheses. Rigorous research is needed to explore whether these hypotheses are accurate. I would welcome feedback.
@threadreaderapp unroll
This thread discusses hypotheses for how high-dose thiamine could benefit people with ME-CFS and EDS. Formal research needed. Would appreciate your help linking to researchers in the field. @jenbrea @jeff_says_that
This thread discusses hypotheses for how high-dose thiamine could benefit people with ME-CFS and EDS. Formal research needed. Would appreciate your help linking to researchers in the field. @karenphysiocouk @TomKindlon @exceedhergrasp1 @PhysiosForME @ahandvanish @bendymarsh
@Prettyill -- an in vitro study found high-speed thiamine is a carbonic anhydrase inhibitor with potency approaching acetazolamide. Scroll thread for links re potential implications for EDS and ME-CFS. pubmed.ncbi.nlm.nih.gov/22145674/
It has been a while since we corresponded about the potential of high-dose thiamine to address post-exertional malaise. Scroll up for some links to a journal letter and paper that may be of interest. Would welcome feedback. @ClagueNjc36 @Dr_M_Guthridge
• • •
Missing some Tweet in this thread? You can try to
force a refresh
